| Oriel Cardi Bach Ltd | Wholesale & retail | 2024 |
| Original Engineering Ltd | Professional & scientific | 2015 |
| Orlando Water Pumps UK Limited | Extraterritorial | 2018 |
| Ortir Ltd | Agriculture & fishing | 2021 |
| Owen Scaffolding Limited | Construction | 2023 |
| Oxygen Therapy Centre Cardigan Ltd | Health & social care | 2006 |
| P.L.D. Land Investment Limited | Construction | 1987 |
| P.O.D.45 Limited | Wholesale & retail | 1997 |
| PAR Art Limited | Wholesale & retail | 2019 |
| Parc Circuit Technology Limited | Wholesale & retail | 2001 |
| Parc Gwynfryn Services Limited | Water & waste | 2014 |
| Parthian Books Ltd | Information & communication | 1996 |
| Pasta a Mano Ltd | Hospitality | 2025 |
| Paul Edwards Limited | Construction | 2002 |
| PB Assets Limited | Real estate | 2025 |
| Pelican Worldwide Travel Ltd | Administrative & support | 2022 |
| Pembrokeshire Craft Makers Limited | Wholesale & retail | 2010 |
| Penny Electrical Ltd | Construction | 2002 |
| Penrallt Garden Centre Limited | Wholesale & retail | 2002 |
| Penrallt Group Ltd | Hospitality | 2021 |
| Penrallt Hospitality Ltd | Hospitality | 2021 |
| Pensarnddu Fach Limited | Agriculture & fishing | 2014 |
| Penstar Ltd | Wholesale & retail | 2001 |
| Penstar Process and Technical Services Limited | Construction | 1992 |
| Pentre Cottages Limited | Hospitality | 2018 |
| Pentre Ifan CYF | Other services | 2013 |
| Performance Clothing U.K. Limited | Manufacturing | 2004 |
| Permawise LLP | | 2023 |
| Permawise Produce Limited Partnership | | 2020 |
| Peter M James Limited | Construction | 2005 |
| Phil Edwards & SON Limited | Construction | 2008 |
| Phill Davies Building Contractor Limited | Construction | 2005 |
| Phonics International Limited | Administrative & support | 2009 |
| Phrike Limited | Information & communication | 2014 |
| PJ Harrison Consulting Ltd | Professional & scientific | 2022 |
| Pjlaro Ltd | Administrative & support | 2016 |
| PK Windows (Wales) Ltd | Construction | 2012 |
| Plas Pedol CYF | Agriculture & fishing | 2025 |
| PMR Electrical Services Limited | Construction | 2006 |
| Poo-Ch Pouch Limited | Wholesale & retail | 2025 |
| Popty Kates Limited | Manufacturing | 2023 |
| Porfa LAS CYF | Water & waste | 2017 |
| Praxis Engineering Ltd | Professional & scientific | 2026 |
| Preseli Home Improvements Ltd | Construction | 2012 |
| Preseli Planning Ltd | Professional & scientific | 2025 |
| Pricewisetaxi Ltd | Transport & logistics | 2017 |
| Principal Services Limited | Information & communication | 2002 |
| Principality Developments Limited | Construction | 1987 |
| Project 7 Developments Ltd | Construction | 2017 |
| Property Refurb Builders Ltd | Construction | 2019 |
| Property Refurb Ltd | Real estate | 2005 |
| PROSIECT2020 CIC | Administrative & support | 2024 |
| Proudman Ltd | Manufacturing | 2016 |
| Pwynt Glas Ltd | Transport & logistics | 2024 |
| PYM My Wine Limited | Administrative & support | 2017 |
| Qeltik Limited | Manufacturing | 2008 |
| Quartz Wick Limited | Wholesale & retail | 2025 |
| Quartzcoat Limited | Construction | 2005 |
| R a Davies Plumbing & Heating Limited | Construction | 2003 |
| R J Financial Planning Limited | Financial services | 2013 |
| R L Plant & Agri Limited | Agriculture & fishing | 2013 |
| RAT PIE Ltd | Manufacturing | 2026 |
| Rbis Properties Limited | Construction | 2014 |
| Red Dragon Events Limited | Administrative & support | 2015 |
| Red Dragon Produce Ltd | Wholesale & retail | 2025 |
| Redeveloped Limited | Construction | 2024 |
| Reed East Wood Limited | Transport & logistics | 2025 |
| Release Your Shooting Star Ltd | Health & social care | 2021 |
| Richard Line & Sons Limited | Construction | 2015 |
| Richards Bros Travel Ltd | Administrative & support | 2014 |
| Risen-Up Virtual Assistants Ltd | Administrative & support | 2025 |
| RM Morris Ltd | Wholesale & retail | 2012 |
| Robert Davies Motors Limited | Wholesale & retail | 2002 |
| RTS Lime Conservation Ltd | Construction | 2024 |
| RW Industries Limited | Manufacturing | 2017 |
| Safe Electricals Limited | Information & communication | 1989 |
| Salient Design Ltd | Professional & scientific | 2019 |
| Sarah Imran Ltd | Hospitality | 2023 |
| SATHMAN1 Ltd | Health & social care | 2025 |
| Savvypro Ltd | Professional & scientific | 2023 |
| Seconds Ahead | | 1997 |
| Seehowyoufeel Ltd | Information & communication | 2021 |
| Selva Coaching Limited | Education | 2024 |
| Sema Design Limited | Professional & scientific | 2020 |
| Shane Griffiths & SON Ltd | Construction | 2010 |
| Shatun Sharha Ltd | Hospitality | 2017 |
| Shebib Dental Limited | Health & social care | 2019 |
| Shibwns Ltd | Hospitality | 2025 |
| Shireglobe Computers Limited | Information & communication | 1989 |
| Sillaf CYF | Administrative & support | 2004 |
| Silvaglide Building Products (Wales) Limited | | 1974 |
| Siop Aderyn Ltd | Wholesale & retail | 2021 |
| SIP Syrup Limited | Manufacturing | 2024 |
| Skeleton Ltd | Real estate | 2011 |
| Sloeberry Farm Ltd | Hospitality | 2018 |
| Small World Theatre Ltd | Arts & recreation | 1996 |
| Solid Designs Internet Solutions Limited | Information & communication | 2007 |
| Southern Roots Organics Ltd | Agriculture & fishing | 2017 |
| Spacetocreate Community Interest Company | Arts & recreation | 2009 |
| Special Stages Limited | Wholesale & retail | 2001 |