| Design Sublime Ltd | Professional & scientific | 2019 |
| Design Tribe UK Ltd | Professional & scientific | 2008 |
| Designed Precision Limited | Professional & scientific | 2025 |
| Designer Drives and Patios Limited | Administrative & support | 2021 |
| Designer German Kitchens (Glasgow) Ltd | Administrative & support | 2016 |
| Designer Mobile Apps Ltd | Construction | 2013 |
| Designer Radiator Concepts Ltd | Wholesale & retail | 2018 |
| Designldn Limited | Professional & scientific | 2014 |
| Designmakers Print House Ltd | Professional & scientific | 2009 |
| Designs Tree Ltd | Wholesale & retail | 2026 |
| Designtidy Limited | Professional & scientific | 1966 |
| Designworld Limited | Professional & scientific | 2007 |
| Desire X Consultancy Ltd | Professional & scientific | 2024 |
| Desirenothing Ltd | Wholesale & retail | 2025 |
| Desiya Ltd | Wholesale & retail | 2026 |
| Desk Thor Limited | Manufacturing | 2025 |
| Deskvest Ltd | Information & communication | 2013 |
| Desmangles Limited | Professional & scientific | 2016 |
| Desobra Logistics Limited | Transport & logistics | 2021 |
| Desperado Cheff Ltd | Hospitality | 2021 |
| Dessert Box Limited | Professional & scientific | 2010 |
| Dessivives Ltd | Administrative & support | 2025 |
| Destina Tourism Ltd | Wholesale & retail | 2025 |
| Destination Weddings (UK) Ltd | Extraterritorial | 2012 |
| Destiny Clouds Limited | Professional & scientific | 2016 |
| Destiny Living Limited | Real estate | 2016 |
| Destiny Plus Driving and Companionship Services Ltd | Health & social care | 2019 |
| Destxgroup Ltd | Wholesale & retail | 2025 |
| Destyle Ltd | Wholesale & retail | 2021 |
| Desvo Ltd | Wholesale & retail | 2016 |
| Detail Media LLP | | 2021 |
| Detectortek Limited | Manufacturing | 2019 |
| Detty VIP Ltd | Transport & logistics | 2025 |
| Deutscher Sekretariatsservice Ltd | Administrative & support | 2010 |
| Deutschland Montreux Fertilizer Ltd | Mining & quarrying | 2025 |
| DEV Match Ltd | Wholesale & retail | 2021 |
| DEV1 Limited | Construction | 2018 |
| DEV2SERVE Limited | Information & communication | 2019 |
| Devacharm Limited | Real estate | 1998 |
| Devandi Corporation Ltd | Information & communication | 2020 |
| Devdib Ltd | Extraterritorial | 2023 |
| Devefinance Ltd | Information & communication | 2024 |
| Develop Improve Grow Solutions Ltd | Administrative & support | 2012 |
| Develop US Communities C.I.C. | Education | 2018 |
| Developex Properties Ltd | Real estate | 2024 |
| Developify Limited | Information & communication | 2013 |
| Developing World Clothing Ltd | Professional & scientific | 2011 |
| Development and Capital Limited | Real estate | 2016 |
| Development Operations & Administration (UK) Ltd | Administrative & support | 2020 |
| Development Trusts Association Wales | Other services | 2003 |
| Development X Ltd | Information & communication | 2014 |
| Developments by Devine Ltd | Construction | 2024 |
| Developments Made Simple Ltd | Real estate | 2024 |
| Devericment Ltd | Wholesale & retail | 2024 |
| Devestates Limited | Construction | 2004 |
| Devhouse Technologies Ltd | Wholesale & retail | 2023 |
| Device Protect Ltd | Administrative & support | 2018 |
| Devil JIN Ltd | Wholesale & retail | 2025 |
| Devina Joseph Albert Ltd | Education | 2021 |
| Devine Health & Care Limited | Health & social care | 2012 |
| Devine Property Management Ltd | Real estate | 2019 |
| Devmaboynurd Ltd | Other services | 2025 |
| Devolta Security Ltd | Administrative & support | 2019 |
| Devon Carpentry and Construction Ltd | Construction | 2018 |
| Devon Mini Market Ltd | Wholesale & retail | 2020 |
| Devon Pubs Limited | Hospitality | 2019 |
| Devon SKI Ltd | Wholesale & retail | 2015 |
| Devonald Johns LLP | | 2007 |
| Devonshire Fisheries Loughborough Ltd | Hospitality | 2022 |
| Devops Ltd | Information & communication | 2025 |
| Devperks Ltd | Information & communication | 2025 |
| Devplay Ltd | Information & communication | 2020 |
| Devrally Technology Consulting Ltd | Information & communication | 2024 |
| Devrow Estates Limited | Construction | 1962 |
| Devtech Solutions Ltd | Information & communication | 2023 |
| Devtv Limited | Manufacturing | 2019 |
| DEW Bees Limited | Wholesale & retail | 2018 |
| DEW99 Ltd | Transport & logistics | 2026 |
| Dewan Catering Ltd | Hospitality | 2016 |
| Dewi Evans Paediatric Consulting Limited | Health & social care | 2010 |
| Dewi Thomas Cardiology Ltd | Health & social care | 2019 |
| Dewis Financial Planning Ltd | Professional & scientific | 2025 |
| Dewlle Ltd | Financial services | 2026 |
| Dews Productions Limited | Information & communication | 2019 |
| Dexalion Ltd | Wholesale & retail | 2025 |
| Dexc Ltd | Information & communication | 2025 |
| Dexterous Property Limited | Real estate | 2018 |
| Dexton Solutions Limited | Administrative & support | 2020 |
| Deyas Tech Limited | Professional & scientific | 2025 |
| Dezayee Store Ltd | Wholesale & retail | 2019 |
| DF 99 Ltd | Hospitality | 2016 |
| DFE Properties Limited | Real estate | 2018 |
| DFH Global Logistics (UK) Ltd | Transport & logistics | 2025 |
| Dflx Limited | Information & communication | 2024 |
| Dfsuk Ltd | Wholesale & retail | 2026 |
| DG (Law) Limited | Professional & scientific | 2004 |
| DG Asset Management Ltd | Financial services | 2019 |
| DG Euphoria Global Services Limited | Information & communication | 2025 |
| DG Events Ltd | Hospitality | 2026 |
| DG Gateways Ltd | Manufacturing | 2025 |