| Denscrubs Limited | Wholesale & retail | 2025 |
| Density Properties Ltd | Real estate | 2022 |
| Denstone Court Management Company Limited | Real estate | 2005 |
| Dent Repair Service Limited | Wholesale & retail | 2008 |
| DENT1ST Limited | Professional & scientific | 2012 |
| Dental Care Nailsea Ltd | Health & social care | 2021 |
| Dental OP Limited | Health & social care | 2020 |
| Dental Scribe Ltd | Health & social care | 2021 |
| Dental Scribe Media Limited | Information & communication | 2024 |
| Dentalent Limited | Administrative & support | 2015 |
| Dentalnova Limited | Health & social care | 2019 |
| Dentaverse.Eth Ltd | Other services | 2022 |
| Dentniko Limited | Health & social care | 2024 |
| Denton RPA Limited | Health & social care | 2018 |
| Denton Wharf Limited | | 1959 |
| Dents/Paints Plus Limited | Wholesale & retail | 2003 |
| Dentures@Nailsea Ltd | Health & social care | 2016 |
| Denval Co Limited | Manufacturing | 2000 |
| Denvalco Limited | Professional & scientific | 2011 |
| Denvalco Maintenance Ltd | Professional & scientific | 2011 |
| Denver Drilling Services Limited | Construction | 2011 |
| Denys Developments Ltd | Construction | 2019 |
| Deonis Limited | Wholesale & retail | 2023 |
| Deosah Limited | Wholesale & retail | 2021 |
| DEP NHF1 Ltd | Professional & scientific | 2017 |
| Depass Limited | Construction | 2025 |
| Dependable Healthcare Solutions Ltd | Public administration | 2019 |
| Deph Labs Ltd | Health & social care | 2025 |
| Depict UK Limited | Information & communication | 2004 |
| Depilex Beauty Saloon Limited | Other services | 2018 |
| Deploy Tech Ltd | Manufacturing | 2020 |
| Depointer Ltd | Wholesale & retail | 2023 |
| Deporo Ltd | Wholesale & retail | 2024 |
| Depot Bristol Limited | Other services | 2021 |
| Depot Marketing Limited | Other services | 2017 |
| Depot Warehouse Limited | Other services | 2015 |
| Depresty Ltd | Hospitality | 2019 |
| Deptford Broadway Development Limited | Construction | 2014 |
| Depw Limited | Real estate | 2019 |
| Derah 12495 Limited | Wholesale & retail | 2024 |
| Derailleur Ltd | Information & communication | 2026 |
| Deraya Securities Ltd | Professional & scientific | 2024 |
| Derby City Cars Limited | Extraterritorial | 2017 |
| Derbyshire Designs Limited | Wholesale & retail | 2024 |
| Derbyshire Wine Company Limited | Wholesale & retail | 2010 |
| Derecos Limited | Financial services | 1996 |
| Derfoti Services Ltd | Wholesale & retail | 2021 |
| Deri Holdings 2024 Ltd | Real estate | 2024 |
| Deri Holdings Limited | Financial services | 1966 |
| Deri Investments Limited | Real estate | 1949 |
| Deri Road Management Company Limited | Households | 1996 |
| Deri Stores Limited | Wholesale & retail | 1980 |
| Deria Limited | Administrative & support | 2016 |
| Derkach Ltd | Construction | 2025 |
| Derkiks Digital Limited | Information & communication | 2026 |
| Dermaclears Limited | Wholesale & retail | 2020 |
| Dermal Filler Next Day Limited | Other services | 2022 |
| Dermalax Fillers Ltd | Information & communication | 2019 |
| Dermaskin Ltd | Health & social care | 2020 |
| Dermcare Limited | Health & social care | 2012 |
| Dermedica Limited | Health & social care | 2022 |
| Dermoaz Limited | Other services | 2018 |
| Derotei Recruits Ltd | Other services | 2019 |
| Derow TD Ltd | Wholesale & retail | 2024 |
| Derrick Sharp Ltd | Wholesale & retail | 2023 |
| Derrick&Co. Plastering and Rendering Ltd | Construction | 2024 |
| Derrix Trade PC | | 2017 |
| Derwen Consultants Limited | Professional & scientific | 1987 |
| Derwen MAY Homes Limited | Construction | 2024 |
| Derwin Estates (Cardiff) Limited | Real estate | 1969 |
| Deryn Properties (Investment) LLP | | 2009 |
| DES Finance Ltd | Professional & scientific | 2024 |
| DES Mcdonald Restaurants ETC Limited | Hospitality | 2011 |
| DES Pardes Cardiff Limited | Hospitality | 2019 |
| Desert Dress Limited | Manufacturing | 2018 |
| Desert Iron Investments Ltd | Mining & quarrying | 2021 |
| Desert Rock Ltd | Real estate | 2018 |
| Desert Roots Ltd | Wholesale & retail | 2024 |
| Desg Limited | Real estate | 2020 |
| Deshte Ltd | Information & communication | 2016 |
| Desi Balti Ltd | Hospitality | 2019 |
| Desi Bazar Cardiff Ltd | Wholesale & retail | 2025 |
| Desi Dera Cardiff Ltd | Hospitality | 2025 |
| Desi Point Manchester Ltd | Hospitality | 2024 |
| Design 2 Publish Limited | Information & communication | 2026 |
| Design Abled Ltd | Manufacturing | 2020 |
| Design Build Refurbishment Ltd | Construction | 2019 |
| Design Chowk Ltd | Wholesale & retail | 2026 |
| Design DAD Ltd | Other services | 2021 |
| Design Development Construction Management Ltd | Construction | 2019 |
| Design Dis.Co Ltd | Information & communication | 2011 |
| Design Doodle Ltd | Wholesale & retail | 2025 |
| Design Garden Limited | Arts & recreation | 2014 |
| Design Innovation Studio Ltd | Wholesale & retail | 2025 |
| Design Interior AI Limited | Information & communication | 2025 |
| Design Line Partnership Limited | Professional & scientific | 2000 |
| Design Salad Limited | Wholesale & retail | 2021 |
| Design Specialists (the Team Works) Limited | Professional & scientific | 1986 |
| Design Stage Ltd | Professional & scientific | 2024 |
| Design Studio Cardiff Limited | Wholesale & retail | 2022 |