| DR D G Stevens Ltd | Health & social care | 2026 |
| DR Erika Manzo Limited | Administrative & support | 2021 |
| DR Kirsten Keighley Ltd | Health & social care | 2020 |
| DR Lindsay Chang Ltd | Professional & scientific | 2022 |
| DR Mukherjee Brain and Spine Ltd | Education | 2024 |
| DR N. Burrows Ltd | Health & social care | 2012 |
| DR Prep Ltd | Education | 2004 |
| DR R Bedir Ltd | Health & social care | 2025 |
| DR Rachel Chen Ltd | Health & social care | 2026 |
| DR Ranjan's Properties Ltd | Real estate | 2024 |
| DR Reddy's Laboratories (UK) Limited | Manufacturing | 1983 |
| DR Richard Martin Limited | Health & social care | 2009 |
| DR Rong Limited | Wholesale & retail | 2019 |
| DR Sarah Psychology and Coaching Limited | Professional & scientific | 2023 |
| DR SEE Limited | Administrative & support | 2022 |
| DR. OGI NE Boli Ltd | Health & social care | 2010 |
| Drache Limited | Wholesale & retail | 2023 |
| Draex Consultancy Ltd | Professional & scientific | 2025 |
| Draex Investments Ltd | Real estate | 2024 |
| Draftspotting Limited | Information & communication | 2025 |
| Dragon Phoenix Trading Ltd | Wholesale & retail | 2026 |
| Dragonfly Digital Limited | Information & communication | 2025 |
| Dragonlight Films Limited | Information & communication | 2018 |
| Dragoon Family Offices Ltd | Administrative & support | 2022 |
| Dragossido Academy Limited | Education | 2018 |
| Drainco Services Limited | Construction | 2009 |
| Drake Heating and Plumbing Ltd | Construction | 2018 |
| Drake Properties and Developments Ltd | Administrative & support | 2023 |
| Drake Technology Limited | Construction | 1993 |
| Drake's Newsagents Limited | Wholesale & retail | 2013 |
| Drawcad Ltd | Arts & recreation | 2021 |
| Drayton Energy Advisory Limited | Administrative & support | 2023 |
| Drayton Financial Ltd | Professional & scientific | 2015 |
| DRB GAS Project Services Ltd | Professional & scientific | 2015 |
| DRC Fire Engineering Limited | Professional & scientific | 2023 |
| DRE2U Ltd | Professional & scientific | 2024 |
| Dream & Co Fictions Ltd | Information & communication | 2016 |
| Dream Globally Limited | Arts & recreation | 2021 |
| Dream of Starlight Ltd | Administrative & support | 2025 |
| Dreamfly INT Limited | Wholesale & retail | 2024 |
| Dreamland Marine Service Co., Ltd | Wholesale & retail | 2024 |
| Drefach Properties Ltd | Construction | 2023 |
| Drengr Ventures UK Ltd | Information & communication | 2024 |
| Drescol Group Ltd | Manufacturing | 2025 |
| Drieng LLP | | 2008 |
| Drisaverse Ltd | Information & communication | 2025 |
| Driscoll International Chemical Co., Ltd | Mining & quarrying | 2026 |
| Drishti Discoveries Ltd. | Professional & scientific | 2019 |
| Drive Well School of Motoring Ltd | Education | 2026 |
| Drivehub Trading & Rentals Ltd | Transport & logistics | 2021 |
| Drivelab Carcare Ltd | Wholesale & retail | 2026 |
| Driver Construction Limited | Construction | 2016 |
| Drivworld Group Co., Ltd | Extraterritorial | 2016 |
| Drop-Tech Ltd | Professional & scientific | 2010 |
| Dropincheckout Limited | Hospitality | 2026 |
| Droxa Ltd | Information & communication | 2025 |
| DRP 1983 Holdings Ltd | Financial services | 2024 |
| DRP 1983 Studio Ltd | Information & communication | 2025 |
| DRP Cambridge Limited | Real estate | 2025 |
| DRT Serviced Ltd | Real estate | 2024 |
| Drug Discovery and Development Consultants Ltd | Professional & scientific | 2018 |
| Drwhale Ltd | Professional & scientific | 2016 |
| DRY Drayton Estate Limited | Real estate | 1997 |
| DS Concept Ltd | Financial services | 2024 |
| DS Developers Ltd | Construction | 2025 |
| DS PDR Ltd | Wholesale & retail | 2023 |
| DSA Composites Limited | Manufacturing | 2018 |
| DSE Lettings Ltd | Real estate | 2020 |
| Dsebas Ltd | Manufacturing | 2026 |
| DSK Toya Services Ltd | Health & social care | 2023 |
| Dsmc Ltd | Health & social care | 2023 |
| DSV GIL Holding Limited | Financial services | 2016 |
| DSV GIL Solutions Limited | Transport & logistics | 2000 |
| DSV GIL UK Limited | Transport & logistics | 1910 |
| DT Lighthouse Limited | Real estate | 2024 |
| DTF Solutions TEC Co., Ltd | Wholesale & retail | 2025 |
| DTL (Nominee) Limited | Financial services | 2020 |
| DTL Data Science Carry LLP | | 2020 |
| DTL Data Science GP Limited | Financial services | 2020 |
| Dubasun Limited | Wholesale & retail | 2024 |
| Dublin Power Limited | Manufacturing | 2021 |
| Ducthub Limited | Extraterritorial | 2018 |
| Duet Diabetes Limited | Education | 2017 |
| Duffee Co., Limited | Manufacturing | 2023 |
| Duffle Fashion Co., Ltd | Extraterritorial | 2020 |
| Duffy Clinical Solutions Limited | Professional & scientific | 2019 |
| Dugout C Holdings Limited | Professional & scientific | 2016 |
| Dugout Holdings LLP | | 2016 |
| Duir Capital Ltd | Professional & scientific | 2019 |
| Duir Structured Finance Ltd | Professional & scientific | 2019 |
| Duke & Read Investments Ltd | Real estate | 2025 |
| Duke & Read Property Partners Ltd | Real estate | 2025 |
| Dukels Limited | Other services | 2014 |
| Dukes Court (Norwich) Management Company Limited | Real estate | 2003 |
| Dulwich Castle Limited | Information & communication | 2025 |
| Dumbletons Photography Limited | Professional & scientific | 2015 |
| Dumitriu Composites Ltd | Manufacturing | 2023 |
| Dumitru RM Ltd | Manufacturing | 2026 |
| Dunad Therapeutics Ltd. | Professional & scientific | 2020 |
| Duncan Howell Limited | Construction | 2006 |