| Sparks Europe Ltd | Information & communication | 2016 |
| Sparks Europe Property Limited | Real estate | 2019 |
| Sparks That FLY Electrical Services Limited | Construction | 2021 |
| Sparrowhawk Software Solutions Limited | Information & communication | 2007 |
| Spartan Concrete Cutting Ltd | Construction | 2018 |
| Spaxman Plumbing & Heating Ltd | Construction | 2012 |
| Spb&Co Ltd | Wholesale & retail | 2025 |
| SPC Realisations Limited | Professional & scientific | 1919 |
| Spearhead Ltd | Information & communication | 2025 |
| Spec Group Ltd | Education | 2023 |
| Specc Ltd | Wholesale & retail | 2024 |
| Special Agent Associates Limited | Professional & scientific | 2004 |
| Special Machining Ltd | Professional & scientific | 2023 |
| Specialeyes (Cambridge) Ltd | Health & social care | 2022 |
| Speciality Security Investigation Group Ltd | Education | 2022 |
| Spectium Ltd | Wholesale & retail | 2026 |
| Spectrum Accommodations Limited | Real estate | 2025 |
| Spectrum Alpha Ltd | Education | 2026 |
| Spectrum DSP Limited | Information & communication | 2018 |
| Spectrum Home Improvements (Cambridge) Limited | Construction | 2005 |
| Speechmatics Limited | Information & communication | 2009 |
| Speed Investments Ltd | Financial services | 2017 |
| Speed Taxis Ltd | Transport & logistics | 2015 |
| Speedfixplumbing Ltd | Construction | 2024 |
| Speedwell Ventures Limited | Hospitality | 2025 |
| Speedy Plumbing & Drain Ltd | Construction | 2026 |
| Speedyggonzalez Ltd | Wholesale & retail | 2025 |
| Spellbrook Property Limited | Real estate | 2020 |
| Spelzini Properties Ltd | Real estate | 2020 |
| Spenceley Tourism and Development Ltd | Administrative & support | 2020 |
| Spencer Mayes Limited | Professional & scientific | 2000 |
| Spencers Supermarket Ltd | Wholesale & retail | 2025 |
| Spencerz Co., Limited | Extraterritorial | 2016 |
| Sphere Property Management Services Limited | Households | 2023 |
| Spice Junction Histon Ltd | Hospitality | 2026 |
| Spider Writing Limited | Information & communication | 2015 |
| Spidr Ltd | Information & communication | 2026 |
| Spikings Homes Limited | Real estate | 2020 |
| Spilt Milk Communications Ltd | Professional & scientific | 2025 |
| Spindup Ltd | Information & communication | 2025 |
| Spinnovations Ltd | Information & communication | 2020 |
| Spinodancemethod Ltd | Information & communication | 2026 |
| Spipman Aviation Engineering Services Ltd | Manufacturing | 2026 |
| Spiral Advisory Limited | Professional & scientific | 2021 |
| Spiritual Directors in Europe | Other services | 2005 |
| Spiro Limited | Information & communication | 2013 |
| Spirometry Limited | Professional & scientific | 2007 |
| Spirus Marketing Limited | Professional & scientific | 2009 |
| Spitfire Aviation Limited | Manufacturing | 2016 |
| Spitfire Productions Limited | Administrative & support | 2008 |
| Spitfire Productions PV202 Limited | Administrative & support | 2024 |
| Spitfire Productions RK858 Limited | Administrative & support | 2024 |
| SPL Utilities Ltd | Construction | 2014 |
| Splash (ST Ives) Ltd | Wholesale & retail | 2008 |
| Spliceor Ltd | Professional & scientific | 2020 |
| Spmn S.A. Ltd | Manufacturing | 2025 |
| Spokang Tech Limited | Manufacturing | 2024 |
| Spooks Specialist Paving & Groundworks Ltd | Construction | 2014 |
| Sporis Aviation Ltd | Manufacturing | 2023 |
| Sport and Thought, Football AS Therapy | Arts & recreation | 2013 |
| Sport=Thought Limited | Arts & recreation | 2013 |
| Sportacre Limited | Other services | 2026 |
| Sportivater Limited | Education | 2013 |
| Sports City Manchester (UK) Ltd | Real estate | 2022 |
| Sports Development Marketing UK Ltd | Administrative & support | 2016 |
| Spot My Talent Worldwide Ltd | Information & communication | 2021 |
| Spotta Limited | Manufacturing | 2018 |
| Spreadmain Limited | Real estate | 1984 |
| Spreadsheet Joy Limited | Information & communication | 2023 |
| Spriggs Building Management Limited | Construction | 2012 |
| Spring Hall Solutions Ltd | Professional & scientific | 2019 |
| Spring Island Limited | Real estate | 2019 |
| Spring Publishing Ltd | Information & communication | 2022 |
| Springboard Pro Ltd. | Professional & scientific | 2013 |
| Springboard Talent Limited | Professional & scientific | 2022 |
| Springer Design & Development Ltd | Extraterritorial | 2006 |
| Springfield Village Estate Limited | Real estate | 2018 |
| Springmead Court Management (Sandhurst) Limited | Households | 1988 |
| Springtail Productions CIC | Professional & scientific | 2023 |
| Springwood Design Engineering Limited | Professional & scientific | 2016 |
| Sprocket Consulting Ltd | Information & communication | 2018 |
| Sprout Innovation Ltd | Other services | 2024 |
| Spud Cambridge Ltd | Professional & scientific | 2025 |
| Spurlay Limited | Wholesale & retail | 2025 |
| SPV Investments Ltd | Wholesale & retail | 2025 |
| SQ Rentals Ltd | Real estate | 2023 |
| Sqlpandit Limited | Information & communication | 2014 |
| Sqorble Ltd | Information & communication | 2025 |
| Square UP Films Ltd | Information & communication | 2022 |
| Squires Court (Chalons Way) Management Company Limited | Households | 2005 |
| Squires Gate (One) Management Company Limited | Households | 2007 |
| Squirrelistic Ltd | Information & communication | 2014 |
| Sqwish Ltd | Information & communication | 2024 |
| SR a and a Limited | Financial services | 2016 |
| SR Cambridge Limited | Professional & scientific | 2018 |
| SRF Shipping and Trading Co., Ltd | Extraterritorial | 2012 |
| SRI Gurudev Traders Ltd | Wholesale & retail | 2025 |
| Srinivas Kalyan Ltd | Wholesale & retail | 2024 |
| Sririse IT Services Ltd | Information & communication | 2014 |
| SRL Florin Ltd | Manufacturing | 2024 |