| SON of Sunrise Ltd | Professional & scientific | 2021 |
| Sonar Computers Limited | Information & communication | 1992 |
| Song M Ltd | Hospitality | 2023 |
| Songbook Systems Limited | Information & communication | 2019 |
| Songs Repertoires and Productions Limited | Professional & scientific | 2011 |
| Sonia Linens Limited | Wholesale & retail | 2015 |
| Sonike Trading Co., Ltd | Wholesale & retail | 2024 |
| Sonrai Consulting Ltd | Information & communication | 2023 |
| Sony I.A.R. Ltd | Manufacturing | 2025 |
| Sookio Limited | Information & communication | 2008 |
| Sooro Trading Co., Ltd | Wholesale & retail | 2023 |
| Soowise Ltd | Extraterritorial | 2020 |
| Sophia Victoria Limited | Other services | 2013 |
| Sophicam Ltd. | Information & communication | 2005 |
| Sophie Support Services Ltd | Construction | 2019 |
| Sophie Trade Co., Limited | Wholesale & retail | 2015 |
| Sophisticated Games Limited | Information & communication | 1998 |
| Sora Ventures Ltd | Wholesale & retail | 2026 |
| Sorin Auto Motive Ltd | Manufacturing | 2025 |
| Sorin Composites Ltd | Manufacturing | 2024 |
| Sorin Georgescu Ltd | Manufacturing | 2023 |
| Sorinel B Aero Motor Ltd | Manufacturing | 2026 |
| Sortera BIO Limited | Professional & scientific | 2023 |
| Sortition Foundation | Other services | 2017 |
| SOS Children's Villages UK | Professional & scientific | 1997 |
| SOS Childrens' Villages U.K. Trading Limited | Wholesale & retail | 1981 |
| SOS Publications Limited | Information & communication | 1985 |
| Sotine UK Limited | Extraterritorial | 2019 |
| Souanef Properties Ltd | Construction | 2023 |
| Soul Press International Limited | Information & communication | 2017 |
| Soul&Soil Ltd | Wholesale & retail | 2026 |
| Soulful Allure Ltd | Wholesale & retail | 2025 |
| Soulsips Ltd | Hospitality | 2025 |
| Soulstec Ltd | Information & communication | 2014 |
| Soultime Legacy Limited | Professional & scientific | 2017 |
| Soultime Media Limited | Other services | 2017 |
| Soumya Mukherjee IP Ltd | Information & communication | 2026 |
| Sound and Media Supplies Limited | Administrative & support | 2022 |
| Sound and Vision Development Ltd | Arts & recreation | 2021 |
| Sound Mathematics Ltd | Professional & scientific | 2009 |
| Sound on Sound Limited | Information & communication | 1995 |
| Soundcheck Entertainment Group Ltd | Hospitality | 2024 |
| Soutersmith Ltd | Information & communication | 2021 |
| South Africa Shuofute Crop Nutrition Co., Ltd | Mining & quarrying | 2024 |
| South Cambridge Physiotherapy Ltd | Health & social care | 2018 |
| South Cambs Flat Roofing Ltd | Construction | 2025 |
| South Cambs Gospel Trust | Other services | 2007 |
| South Cambs Limited | Real estate | 2012 |
| South China Asset Holdings Limited | Real estate | 2023 |
| South Essex Properties Ltd | Real estate | 2018 |
| South Stoke Capital Ltd | Professional & scientific | 2025 |
| Southampton Global Limited | Education | 2016 |
| Southampton Marine Laboratory (UK) Co., Ltd | Mining & quarrying | 2025 |
| Southbridge Consulting Ltd | Professional & scientific | 2025 |
| Southern Seas (Nanhai) Trading Company Limited | Wholesale & retail | 2013 |
| Sovereign Court Freehold Company Limited | Real estate | 2007 |
| Sovereign Grange (Kings Cliffe) Management Limited | Households | 2012 |
| Sowin Cosmetics UK Limited | Extraterritorial | 2016 |
| SP Easy Clean Ltd | Administrative & support | 2026 |
| SP Educational Assessment Ltd | Education | 2020 |
| Sp-Building Services Limited | Construction | 2011 |
| Space Beach Manufacturing Ltd | Manufacturing | 2025 |
| Space Fleet TV Ltd | Information & communication | 2020 |
| Space Heroes Limited | Information & communication | 2015 |
| Space Lizard Studio Ltd | Information & communication | 2015 |
| Space Loves Design Ltd | Professional & scientific | 2020 |
| Space TEN Management Company Limited | Administrative & support | 2009 |
| Space Time Publications Limited | Information & communication | 1985 |
| Space+ Design Limited | Professional & scientific | 2019 |
| Spacebridge (Emea) Ltd | Manufacturing | 2001 |
| Spacecraft Architecture Ltd | Professional & scientific | 2023 |
| Spaceship Group Limited | Real estate | 2017 |
| Spacestep Property Management Limited | Households | 1990 |
| Spacio Solutions Ltd | Real estate | 2025 |
| Spagbol Insights Ltd | Professional & scientific | 2025 |
| Spain Adira Crop Nutrition Limited | Wholesale & retail | 2024 |
| Spain AI Fine Plant Nutrition and Protection Co., Ltd | Wholesale & retail | 2025 |
| Spain Giffort Chemical Co., Ltd | Wholesale & retail | 2023 |
| Spain Hanweilide Group Limited | Extraterritorial | 2024 |
| Spain Lepu Group Co., Ltd | Mining & quarrying | 2026 |
| Spain Norma Co., Limited | Extraterritorial | 2024 |
| Spain Obeli Crop Nutrition Co., Ltd | Mining & quarrying | 2026 |
| Spain Renard Chemical Group Co., Limited | Extraterritorial | 2023 |
| Spain Schnauer Crop Nutrition Co., Ltd | Mining & quarrying | 2025 |
| Spain Seagate Plant Nutrition Co., Ltd | Mining & quarrying | 2025 |
| Spain Stucy Co., Ltd | Wholesale & retail | 2024 |
| Spain Ulijia International Co., Ltd | Wholesale & retail | 2025 |
| Spain Wagelate Ltd | Wholesale & retail | 2024 |
| Spain Yaketu Crop Nutrition Co., Limited | Extraterritorial | 2025 |
| Spain Yunmu Crop Nutrition Ltd | Mining & quarrying | 2021 |
| Spakls Ltd | Transport & logistics | 2021 |
| Spalding Consultants Ltd | Professional & scientific | 2023 |
| Spanish Spain Hochen Agriculture Co., Ltd | Mining & quarrying | 2024 |
| Spare Tokens Limited | Information & communication | 2026 |
| Spares Trade Distribution Limited | Wholesale & retail | 1999 |
| Spark EV Technology Limited | Information & communication | 2016 |
| Sparkfire Marketing Limited | Professional & scientific | 2021 |
| Sparkle Car Valeting Limited | Administrative & support | 2025 |
| Sparkleduck Ltd | Manufacturing | 2011 |
| Sparkone Media Ltd | Information & communication | 2023 |