| Sherbourne Lodge Limited | Health & social care | 2023 |
| Sheridan House (Cambridge) Limited | Manufacturing | 2006 |
| Sheridan Trading Ltd | Professional & scientific | 2021 |
| Sherif Elsayed Ltd | Health & social care | 2026 |
| Sherkhan Traders Limited | Wholesale & retail | 2025 |
| Sherox Property Limited | Real estate | 2010 |
| Sherriff Tiplady Associates Limited | Professional & scientific | 2004 |
| Sherry Trade Co., Ltd | Wholesale & retail | 2025 |
| Sherwood Scientific Limited | Manufacturing | 1988 |
| Shevlin Investments Ltd | Administrative & support | 2016 |
| Sheymen Ltd | Wholesale & retail | 2021 |
| Shield Purchasing Services Ltd | Professional & scientific | 2025 |
| Shifa Shawrma Ltd | Hospitality | 2026 |
| Shift Bioscience Limited | Professional & scientific | 2017 |
| Shiftxchange Ltd | Information & communication | 2025 |
| Shijiazhuang Adxin Imp&Exp Trading Co., Ltd. | Extraterritorial | 2019 |
| Shijiazhuang Gezi Co., Ltd | Extraterritorial | 2014 |
| Shijiazhuang Runcheng Trading Co., Ltd | Extraterritorial | 2021 |
| Shikumi Ltd | Professional & scientific | 2026 |
| Shilson Consulting Ltd | Professional & scientific | 2025 |
| Shimoga Consultants Ltd | Information & communication | 2026 |
| Shimu (UK) Crop Nutrition Co., Limited | Mining & quarrying | 2026 |
| Shine Boating Co., Ltd | Wholesale & retail | 2025 |
| Shine Carbon & Refractory Co., Ltd | Extraterritorial | 2023 |
| Shine IMP and EXP Co., Limited | Manufacturing | 2019 |
| Shine KP Ltd | Wholesale & retail | 2021 |
| Shine Trade Co., Ltd | Wholesale & retail | 2023 |
| Shines Global Co., Ltd | Wholesale & retail | 2018 |
| Shingaar Bars Limited | Hospitality | 2024 |
| Shingaar Fashions Limited | Wholesale & retail | 2017 |
| Shingaar Properties Ltd | Real estate | 2026 |
| Shinjin Marine Tech Limited | Extraterritorial | 2020 |
| Shinri International Group Co., Ltd | Manufacturing | 2018 |
| Shiosd Limited | Wholesale & retail | 2021 |
| Shipora Ltd | Manufacturing | 2025 |
| SHIRDI999 Limited | Other services | 2023 |
| Shire Construction Limited | Construction | 2013 |
| Shire Enterprise Investments | Financial services | 2017 |
| Shire Homes Lettings Limited | Real estate | 2017 |
| Shirebrook Village NO. 3 Residents Company Limited | Households | 1992 |
| Shirebrook Village NO.4 Residents Company Limited | Households | 1993 |
| Shires Gate (Willingham) Management Company Limited | Households | 2005 |
| Shirley Lodge Residents Association Limited | Real estate | 1972 |
| Shish Bar Hill Ltd | Hospitality | 2026 |
| Shiv Shakti Solutions Limited | Information & communication | 2025 |
| Sholay Limited | Hospitality | 2023 |
| Shoolbred Site Inspections Ltd | Construction | 2020 |
| Shoosh Ltd | Wholesale & retail | 2021 |
| Shooting Star Solutions Ltd | Extraterritorial | 2025 |
| Shop Equipment & Design Ltd | Wholesale & retail | 2016 |
| Shop Fiesta Ltd | Wholesale & retail | 2024 |
| Shopajy Technology Co., Limited | Wholesale & retail | 2025 |
| Shopxpert Ltd | Wholesale & retail | 2026 |
| Shorncliffe Drive Residents Company Limited | Households | 2001 |
| Shortest Path Training Limited | Information & communication | 2013 |
| Shou Yuan Chemical Co., Ltd | Wholesale & retail | 2018 |
| Shouchen Industrial (Hongkong) Co., Ltd | Wholesale & retail | 2024 |
| Shout Platform Ltd. | Information & communication | 2015 |
| Show Deals East Ltd | Administrative & support | 2023 |
| Show Laser Systems Ltd | Manufacturing | 2009 |
| Showcase Consultants Limited | Arts & recreation | 2021 |
| Shpn Limited | Real estate | 2024 |
| Shree Maashakti Properties Ltd | Real estate | 2026 |
| Shri Lakshmiji Limited | Real estate | 2018 |
| Shrinking CAP Productions Limited | Information & communication | 2012 |
| Shuffle Energy Limited | Manufacturing | 2024 |
| Shuffle Shack Limited | Hospitality | 2016 |
| Shun YUE Trading Limited | Manufacturing | 2025 |
| Shunp Electronics Co., Limited | Professional & scientific | 2005 |
| Si-Flux Ltd | Professional & scientific | 2023 |
| SI5 Spymissions Ltd | Arts & recreation | 2005 |
| SIA Trade Services Ltd | Other services | 2023 |
| Siac Health Limited | Extraterritorial | 2022 |
| Siam Atelier Ltd | Arts & recreation | 2026 |
| Siantifix Limited | Professional & scientific | 2012 |
| Sicilian Sunshine Holding Limited | Wholesale & retail | 2025 |
| Sidaway Group Holdings Ltd | Financial services | 2026 |
| Siddharth Group Limited | Real estate | 2018 |
| Siddharth Holdings Ltd | Real estate | 2021 |
| Siddharth One Limited | Real estate | 2018 |
| Siddharth Portfolio Ltd | Information & communication | 2024 |
| Side by Side Companion Limited | Health & social care | 2026 |
| Sidekick Books Ltd | Information & communication | 2017 |
| Sideland Commissioning Limited | Construction | 2011 |
| Sideland Consulting LLP | | 2009 |
| Sideland Design Limited | Construction | 2011 |
| Sideland Group LLP | | 2012 |
| Sideland Holdings Ltd | Professional & scientific | 2006 |
| Sideland Incorporated Limited | Administrative & support | 2013 |
| Sideland Projects Ltd. | Professional & scientific | 2009 |
| Sideland Services Limited | Construction | 2011 |
| Sidequest Ninja Limited | Information & communication | 2019 |
| Sidewalk Coffee Ltd | Wholesale & retail | 2016 |
| Sidis Europe Limited | Professional & scientific | 2025 |
| Sidmouth Court Management Company Limited | Households | 1987 |
| Sidney Sussex Hospitality Limited | Hospitality | 2019 |
| Sidney Sussex Limited | Real estate | 2016 |
| Sidney Sussex Pension Trustee Limited | Administrative & support | 2014 |
| Sido Union Properties Limited | Real estate | 2021 |
| Siere Medical Limited | Health & social care | 2024 |