| Sasa International Trading Co., Ltd | Wholesale & retail | 2025 |
| Sasa Property Trading Ltd | Real estate | 2024 |
| Sashcare Limited | Wholesale & retail | 2019 |
| Sasidharan GI Health Care Ltd | Health & social care | 2025 |
| Saspiphi Limited | Professional & scientific | 2024 |
| Satchell Properties Limited | Real estate | 2005 |
| Satex Systems Ltd | Manufacturing | 2025 |
| Satiima Limited | Information & communication | 2014 |
| Saturn Biosciences Ltd | Professional & scientific | 2009 |
| Saturn.Air Ltd | Manufacturing | 2023 |
| Satyam Yoga Cambridge Ltd | Arts & recreation | 2016 |
| Satyam Yoga Reach Ltd | Education | 2022 |
| Sauber Bridging Finance Limited | Financial services | 2026 |
| Saulescu Mihai Ltd | Manufacturing | 2026 |
| Saunders and Jefferies Consulting Limited | Construction | 2017 |
| Saunderson Asset Management Limited | Financial services | 2009 |
| Sausage Knowles Ltd | Information & communication | 2020 |
| Save My Business Limited | Financial services | 2026 |
| Savec.Ai Limited | Information & communication | 2026 |
| Savernake Technology Limited | Information & communication | 2014 |
| Saveta Compozites Ltd | Manufacturing | 2022 |
| Savile Hotel Group Limited | Extraterritorial | 2024 |
| Savin Mario Alexandru Ltd | Manufacturing | 2025 |
| Savvy AV Group Limited | Construction | 2025 |
| Sawbridge Park (Sawbridgeworth) Management Company Limited | Households | 2021 |
| Sawmoco Ltd | Wholesale & retail | 2014 |
| Sawston Barber Ltd | Other services | 2023 |
| Sawston CAB Co Ltd. | Transport & logistics | 2011 |
| Sawston Carpet & Flooring Limited | Wholesale & retail | 2004 |
| Sawston DRY Cleaners Limited | Other services | 2013 |
| Sawston Farms(Cambs)Limited | Construction | 1957 |
| Sawston Partnership Limited | Wholesale & retail | 2005 |
| Sawston Properties Limited | Real estate | 2024 |
| Sawston Taxis Limited | Transport & logistics | 2025 |
| Sawston Village Stores Ltd | Wholesale & retail | 2021 |
| Sawston Youth Drama Ltd | Arts & recreation | 2014 |
| Saxifrage Environmental Ltd | Professional & scientific | 2021 |
| Saxon Builders Limited | Construction | 2013 |
| Saxon Way Amenity Block B Management Ltd | Households | 2017 |
| SAY Less Works LLP | | 2025 |
| Sayette Services Ltd | Households | 2007 |
| Sayhi International Co., Limited | Wholesale & retail | 2021 |
| Sayiranah Limited | Health & social care | 2018 |
| SB Cabling Ltd | Construction | 2024 |
| SB Planning Ltd | Professional & scientific | 2022 |
| SB Traffic Management Ltd | Public administration | 2026 |
| SB7 Holdings Ltd | Financial services | 2020 |
| SB7 Ltd | Information & communication | 2020 |
| SBA Photography Ltd | Professional & scientific | 2023 |
| SBC Global Alliance Ltd | Other services | 2017 |
| Sbch Ltd | Information & communication | 2026 |
| SBL 2012 Limited | Real estate | 2012 |
| SBS Developers Ltd | Real estate | 2026 |
| SBS Paints Limited | Manufacturing | 2020 |
| SBS Private Hire Limited | Transport & logistics | 2025 |
| SBS Sushi Limited | Hospitality | 2026 |
| Sbsec Limited | Administrative & support | 2024 |
| SC Group Trading Limited | Wholesale & retail | 2024 |
| SC Logistics Bridge Ltd | Wholesale & retail | 2020 |
| SC Squared Limited | Arts & recreation | 2018 |
| SC40 Ltd | Real estate | 2019 |
| Scafix Limited | Financial services | 2018 |
| Scafol.Io Survey Solutions Limited | Information & communication | 2022 |
| Scalarity Limited | Information & communication | 2026 |
| Scale Rule Surveying Limited | Professional & scientific | 2020 |
| Scana Valve Control Co., Ltd | Manufacturing | 2023 |
| Scandinavian Underwriters Agency Limited | Professional & scientific | 1997 |
| Scape Studios Limited | Professional & scientific | 2020 |
| Scar Theatre Ltd | Arts & recreation | 2023 |
| Scare Events Ltd | Arts & recreation | 2015 |
| Scarfe Aviation Limited | Professional & scientific | 2012 |
| Scarper Limited | Professional & scientific | 2013 |
| Scaturio Ltd | Wholesale & retail | 2012 |
| SCC3 Ltd | Professional & scientific | 2025 |
| Scent Supply UK Limited | Wholesale & retail | 2025 |
| Scentscapology Ltd | Wholesale & retail | 2021 |
| Scey Ltd | Wholesale & retail | 2024 |
| Schechter Education Limited | Education | 2025 |
| Schemus Limited | Information & communication | 2008 |
| Schmidt International Chemical (UK) Ltd | Mining & quarrying | 2025 |
| Scholar Sync Ltd | Information & communication | 2025 |
| Scholar's Walk (Leicester) Management Company Limited | Real estate | 2004 |
| Scholares Choir Limited | Arts & recreation | 2023 |
| Scholarly Affairs Ltd | Education | 2025 |
| Scholars Mews (Newark) Phase 2 Residents Management Company Limited | Households | 2016 |
| Scholars Punting Cambridge Ltd | Administrative & support | 2019 |
| Scholars View Holdings Limited | Hospitality | 2025 |
| Scholarslift Ltd | Education | 2026 |
| Scholastica Islamica Limited | Wholesale & retail | 2023 |
| School Court Management (Caldecote) Limited | Real estate | 2006 |
| School Health Pulse Ltd | Education | 2024 |
| School Software Company .COM Ltd. | Information & communication | 2006 |
| Schwarz Aero Ltd | Manufacturing | 2025 |
| SCI BIO Life Sciences Consultancy Limited | Professional & scientific | 2017 |
| SCI7 Ltd | Information & communication | 2005 |
| Sciansell Limited | Manufacturing | 2017 |
| Scie-Plas Limited | Manufacturing | 1988 |
| Science Group PLC | Professional & scientific | 2008 |
| Science History Publications Limited | Information & communication | 1971 |
| Scienta Consulting Ltd | Professional & scientific | 2005 |