| Saleh Investments Ltd | Real estate | 2023 |
| Saleh Rentals LLP | | 2023 |
| Saleyha Ahsan Ltd. | Extraterritorial | 2013 |
| Salje Consultancy Ltd | Professional & scientific | 2024 |
| Sally Lane Education Consultancy Ltd | Education | 2003 |
| Sally Yonge Interiors - Cambridge Division Ltd | Wholesale & retail | 2021 |
| Salomir Technologies Ltd | Information & communication | 2024 |
| Salon 179 Limited | Other services | 2026 |
| Salon K Ltd | Other services | 2025 |
| Salon KBR Ltd | Wholesale & retail | 2026 |
| Salon SE7EN Limited | Other services | 2014 |
| Salon Siberia Ltd | Other services | 2019 |
| Salon TT Ltd | Other services | 2025 |
| Salt Burnt Ltd | Hospitality | 2024 |
| Salt Desert Media Group Limited | Information & communication | 2019 |
| Salter Tech Consulting Limited | Professional & scientific | 2023 |
| Salthouse Sterling Limited | Financial services | 2014 |
| Saltisford Gate (Warwick) Management Company Limited | Households | 2005 |
| Saltisford Gate (Warwick) NO.2 Management Company Limited | Households | 2006 |
| Saltwater Cottages Ltd | Real estate | 2019 |
| Salus Wellness Limited | Other services | 2010 |
| Saluspath Limited | Arts & recreation | 2021 |
| Salvadora Persica Group Ltd | Manufacturing | 2019 |
| SAM & Taki Limited | Hospitality | 2025 |
| SAM Barrett Coaching Ltd | Health & social care | 2025 |
| SAM Gerald Consulting Ltd. | Professional & scientific | 2024 |
| SAM Grain Contracts Ltd | Construction | 2012 |
| SAM Labs Ltd. | Wholesale & retail | 2014 |
| Sam's Production Limited | Information & communication | 2026 |
| Samar SOL Limited | Information & communication | 2012 |
| Samaya Vibes Ltd | Health & social care | 2025 |
| Sambayan Limited | Wholesale & retail | 2024 |
| Samer Maintenance Ltd | Manufacturing | 2025 |
| Samich Global Consultancy Limited | Administrative & support | 2026 |
| Samif Ltd | Transport & logistics | 2014 |
| Samira Hoque's Company Limited | Health & social care | 2022 |
| Samlien Foods Ltd | Hospitality | 2021 |
| Samlien Properties Ltd | Households | 2023 |
| Samson Godfrey Limited | Transport & logistics | 2016 |
| Samsons Paddocks Ltd | Real estate | 2025 |
| Samsuddin Properties Ltd | Real estate | 2025 |
| Samsung Cambridge Solution Centre Limited | Information & communication | 2012 |
| Samuel Barnes Holdings Ltd | Financial services | 2025 |
| Samuraiorca Limited | Information & communication | 2024 |
| SAN CAI Network Technology Co., Ltd | Wholesale & retail | 2025 |
| SAN IT Consultancy Ltd | Information & communication | 2019 |
| SAN JAR Beng Limited | Real estate | 2022 |
| SAN Spectrum Limited | Health & social care | 2012 |
| Sanath Limited | Health & social care | 2015 |
| Sanbloom Co., Ltd | Wholesale & retail | 2026 |
| Sancara Entertainment Ltd | Administrative & support | 2024 |
| Sancho Panza Consultancy Services Limited | Information & communication | 2007 |
| Sand Martins Court Residents Management Company Limited | Households | 2007 |
| Sand Partners Limited | Professional & scientific | 2019 |
| Sandalwood Leisure Limited | Arts & recreation | 2022 |
| Sandbrook Park Management Company Limited | Households | 2015 |
| Sandford Berg Ltd | Financial services | 2025 |
| Sandhill Solution (UK) Limited | Extraterritorial | 2019 |
| Sandilands (Formby) Ltd | Real estate | 2025 |
| Sandisalksnis Limited | Construction | 2018 |
| Sando Cambridge Limited | Professional & scientific | 2024 |
| Sandra's Cleaning Service Ltd | Administrative & support | 2016 |
| Sands Science Ltd | Wholesale & retail | 2023 |
| Sandy Beach Holiday Park Ltd | Hospitality | 2022 |
| Sandy Lane 2021 Limited | Construction | 2021 |
| Sanfer Technologies Limited | Administrative & support | 2025 |
| Sanhe International Group Limited | Wholesale & retail | 2015 |
| Sanitas Healthcare Limited | Manufacturing | 2020 |
| Sanjeev's Kitchen Ltd | Hospitality | 2024 |
| Sanmi Pengjuan Import and Export Co., Limited | Wholesale & retail | 2023 |
| Sanou Company Limited | Professional & scientific | 2017 |
| Sanskruti Cambridge CIC | Arts & recreation | 2021 |
| Sansri Private Limited | Real estate | 2025 |
| Santa Catalina Limited | Hospitality | 2020 |
| Santos Valente Ltd | Health & social care | 2023 |
| Sanwaters Limited | Information & communication | 2026 |
| Sanwoz Enterprise Ltd | Manufacturing | 2017 |
| Sanyang Technology Ltd | Manufacturing | 2025 |
| Sanyu Cambridge Ltd | Hospitality | 2021 |
| SAO Communications Consulting Limited | Professional & scientific | 2017 |
| SAP Opinion Co., Ltd | Other services | 2021 |
| Saph Limited | Professional & scientific | 2026 |
| Sapien Innovations Limited | Professional & scientific | 2009 |
| Sapinfo Ltd | Information & communication | 2013 |
| Sappa International Ltd | Wholesale & retail | 2023 |
| Sapphire Securities 2016-1 LP | | 2016 |
| Sapratings.Com Ltd | Administrative & support | 2007 |
| Sara Slade Ltd | Professional & scientific | 2012 |
| Sarah a Smith Limited | Health & social care | 2014 |
| Sarah Gledhill Ltd | Professional & scientific | 2021 |
| Sarah Griggs Limited | Professional & scientific | 2011 |
| Sarah International Trading Co., Ltd | Wholesale & retail | 2023 |
| Sarah Rose Limited | Real estate | 2011 |
| Sarang Properties Limited | Real estate | 2020 |
| Sardo Holdings Ltd | Real estate | 2018 |
| Sareum Holdings PLC | Professional & scientific | 2004 |
| Sareum Limited | Professional & scientific | 2003 |
| Sarik Ltd | Real estate | 2005 |
| Sarvesh IT Solutions Ltd | Information & communication | 2018 |
| Sarya Berkay Ltd | Transport & logistics | 2019 |