| Daffs Ltd | Professional & scientific | 2024 |
| Dale Road (Buxton) Management Company Limited | Households | 2004 |
| Dalmore Property Limited | Real estate | 2021 |
| Dameon's Frames Limited | Construction | 2026 |
| Damian Grainer Consultancy Ltd | Professional & scientific | 2012 |
| Danny Smart Limited | Real estate | 2023 |
| Darley Moor Paramotoring Limited | Arts & recreation | 2017 |
| Darren R Hall Concreting & Groundworks Ltd | Construction | 2025 |
| Dave Cross Consultancy Services Limited | Information & communication | 2006 |
| David Bowyer Limited | Information & communication | 2020 |
| David Mcphie (UK) Ltd. | Wholesale & retail | 2001 |
| Day Empire Group Ltd | Wholesale & retail | 2025 |
| Dedicated Programmes Limited | Information & communication | 1998 |
| Delphi Properties & Design Limited | Real estate | 2024 |
| Denham Peaks Ltd | Professional & scientific | 2020 |
| Derbyshire Castles & Events Limited | Administrative & support | 2022 |
| Derbyshire Districts Citizens Advice Bureau | Public administration | 2002 |
| Derbyshire DRY Stone Co Ltd | Administrative & support | 2025 |
| Derbyshire Geotechnical Ltd | Construction | 2017 |
| Derbyshire Plant Hire Ltd | Administrative & support | 2017 |
| Derbyshire Reclamation & Salvage Ltd | Wholesale & retail | 2021 |
| Dermabeauty Aesthetics Ltd | Other services | 2021 |
| Dervdoctor Limited | Manufacturing | 2022 |
| Design Social Group Ltd | Professional & scientific | 2022 |
| Design to Launch Limited | Administrative & support | 2023 |
| Designx Engineering Ltd | Professional & scientific | 2019 |
| DH & MA Developments Limited | Construction | 2016 |
| Diamond House Spirits Ltd | Manufacturing | 2024 |
| Dickson Wharf Limited | Administrative & support | 2005 |
| Difficult Access Solutions Limited | Construction | 2008 |
| Diners Readymade Garments UK Ltd | Wholesale & retail | 2020 |
| Dingleside Management (Buxton) Limited | Real estate | 1986 |
| Discrete Time Communications (UK) Limited | Information & communication | 2002 |
| Diverse Beers Limited | Wholesale & retail | 2019 |
| Diversity Learning Ltd | Health & social care | 2024 |
| Divine Trash Limited | Wholesale & retail | 2006 |
| DJR Asset Management Limited | Water & waste | 2010 |
| Dobbies Sock Consultancy Ltd | Information & communication | 2021 |
| Doceupoint Limited | Professional & scientific | 2009 |
| Doctor English Limited | Health & social care | 2009 |
| Doing Business Ltd | Information & communication | 2024 |
| Domestic Bliss Exclusive Housekeeping Limited | Administrative & support | 2011 |
| Dove Holes 1972 Limited | Extraterritorial | 2015 |
| Dove Service Centre Ltd | Wholesale & retail | 2018 |
| Dove Valley Shepherds Huts Limited | Administrative & support | 2021 |
| Dragon Hill Communications Limited | Professional & scientific | 2021 |
| Driven I Limited | Extraterritorial | 2011 |
| Drmds Ltd | Transport & logistics | 2026 |
| Drysdale Umbrellas Limited | Wholesale & retail | 2024 |
| Dunford & Pearson Ltd | Manufacturing | 2002 |
| Durrant Farming Ltd | Agriculture & fishing | 2020 |
| Dutch Maid Company Limited(The) | Hospitality | 1983 |
| Dutch Maid Holdings Limited | Professional & scientific | 2010 |
| DW Dwellings Ltd | Real estate | 2024 |
| Dwcb Construction Limited | Construction | 2006 |
| E & C Products Ltd | Other services | 2016 |
| E J Teeboon Limited | Other services | 2020 |
| E-Volve IT Support Limited | Information & communication | 2013 |
| Each Solutions Ltd | Professional & scientific | 2026 |
| Eagle Parade (Management) Company Limited | Households | 1991 |
| Earth, Stone & Mortar Ltd | Administrative & support | 2026 |
| Eaves Chimney Specialists Limited | Administrative & support | 2005 |
| ECL Camps Ltd | Administrative & support | 2026 |
| Ecological & Environmental Solutions Ltd. | Construction | 2019 |
| Ecostar Dangerous Goods Training Online Ltd. | Information & communication | 2016 |
| Ecton Limited | Professional & scientific | 2021 |
| Eddie Bennett & Sons Builders Limited | Construction | 2009 |
| Edge Close Green Energy Limited | Energy | 2016 |
| EDS Design Solutions LLP | | 2012 |
| Edward James Financial Planning Limited | Professional & scientific | 2020 |
| Edwards Consultancy and Engineering Services Limited | Professional & scientific | 2015 |
| EFS Consulting Limited | Professional & scientific | 2025 |
| Eighty Two Software Limited | Administrative & support | 2016 |
| EKO 19 Ltd | Construction | 2025 |
| EKO19 Solar Ltd | Wholesale & retail | 2025 |
| Eldritch.Girl Ltd | Wholesale & retail | 2024 |
| Electric Lighting Company Ltd | Manufacturing | 2026 |
| ELEV8INVEST Limited | Real estate | 2025 |
| Elevatehx Ltd | Professional & scientific | 2025 |
| Elfinspire Ltd | Education | 2021 |
| Elite Subbies Ltd | Construction | 2022 |
| Elliott and Wragg Ltd | Construction | 2007 |
| Elliott Farms TW Limited | Financial services | 2025 |
| ELS Management & Consultancy Limited | Information & communication | 2000 |
| Elys Estates Limited | Real estate | 2026 |
| Emerald Trading Ltd | Manufacturing | 2024 |
| Emilie Grace Financial Planning Limited | Professional & scientific | 2020 |
| Emma Beeson Horse Disposal Limited | Transport & logistics | 2011 |
| Energise Electronics Ltd | Information & communication | 2015 |
| Englehurst Property Company Ltd | Real estate | 2025 |
| Enrail Consulting Limited | Professional & scientific | 2022 |
| EOG Holdings Ltd | Real estate | 2020 |
| Equip (Midlands) Limited | Wholesale & retail | 1999 |
| Equip Limited | Extraterritorial | 2009 |
| Equipment Validation Services Ltd. | Professional & scientific | 2002 |
| Equity Trading Ltd | Information & communication | 2026 |
| Escalier.Mc Limited | Manufacturing | 2024 |
| Etadom Ltd | Real estate | 2005 |
| Event Soundtracks Limited | Arts & recreation | 2025 |
| Evic Clean Limited | Administrative & support | 2025 |