| Cashmore Farming Ltd | Agriculture & fishing | 2023 |
| Cashmore Properties Ltd | Real estate | 2026 |
| CAST1617 Limited | Other services | 2016 |
| Castcliffe Properties Ltd | Construction | 2003 |
| Caterfresh Limited | Extraterritorial | 2011 |
| Cavendish Golf Club Limited(The) | Arts & recreation | 1954 |
| Cavendish Pizza Limited | Hospitality | 2024 |
| Celsia Systems Ltd | Extraterritorial | 2004 |
| Cetroc Ltd | Wholesale & retail | 2026 |
| CF Builders Ltd | Construction | 2010 |
| CH Accountancy Services (High Peak) Limited | Professional & scientific | 2014 |
| Chadderton Homes Ltd | Construction | 2025 |
| Charles George Holdings Limited | Financial services | 2026 |
| Charles George Investments Ltd | Financial services | 2023 |
| Charley Mycock Golf Ltd | Arts & recreation | 2021 |
| Charnock - Flintson Protection Solutions Ltd | Financial services | 2011 |
| Cherry Paddock Ltd | Professional & scientific | 2021 |
| Cherry Tree Film and Productions Limited | Information & communication | 2024 |
| Cheshire Cat (Macclesfield) Limited | Wholesale & retail | 2002 |
| Cheshire Elite Joinery Limited | Construction | 2022 |
| Cheshire Ground Control Limited | Construction | 2021 |
| Chilba Limited | Information & communication | 2026 |
| Chili Pepper Company Limited | Real estate | 2022 |
| China House Catering Ltd | Wholesale & retail | 2025 |
| Choc LE Tea Ltd | Wholesale & retail | 2010 |
| Choiceunit Property Management Limited | Households | 1988 |
| Chris Burns (Buxton) Limited | Manufacturing | 2017 |
| Chris Goodwin Media Limited | Information & communication | 2025 |
| Chris Green Plumbing & Heating Limited | Construction | 2022 |
| Chris Martin Plumbing & Heating (Buxton) Limited | Construction | 2012 |
| Chris Martin Plumbing and Heating Ltd | Construction | 2023 |
| Chrisalan Productions Limited | Arts & recreation | 2021 |
| Chronoedge Limited | Wholesale & retail | 2013 |
| Churchbridge Property Limited | Real estate | 2021 |
| City Shawarma Ltd | Hospitality | 2024 |
| City Shawrma 1 Limited | Hospitality | 2026 |
| CJS Builders Buxton Limited | Construction | 2016 |
| Classic Car Adventures Ltd | Administrative & support | 2021 |
| Classic PAY Ltd | Other services | 2011 |
| Clear View Window Cleaning High Peak Limited | Administrative & support | 2006 |
| Clear View Windows (High Peak) Ltd | Construction | 2010 |
| Clearer Thinking Limited | Professional & scientific | 2012 |
| Clegg Norman Limited | Hospitality | 2015 |
| Clevedon Materials Processing Consultancy Limited | Mining & quarrying | 2017 |
| Clive Andrews Ltd | Professional & scientific | 2012 |
| Coach House Productions Ltd | Information & communication | 2018 |
| Coeurage Ltd | Extraterritorial | 2009 |
| Cogent Logic Limited | Information & communication | 2022 |
| Cold Springs Farm GUN Club Ltd | Arts & recreation | 2024 |
| College View Apartments Limited | Households | 2023 |
| Comcek Consulting Ltd | Professional & scientific | 2024 |
| Commercial Estates Limited | Real estate | 1960 |
| Compton Garage Limited | Wholesale & retail | 2004 |
| Compton Guest House Limited | Hospitality | 2015 |
| Conformance Limited | Professional & scientific | 1997 |
| Consortium Business Services Limited | Real estate | 2014 |
| Constantine Commercial Properties Limited | Real estate | 2025 |
| Contactless Media Limited | Information & communication | 2020 |
| Cooper Sons Hartley and Williams LLP | | 2019 |
| Corbar Accounting Ltd | Professional & scientific | 2024 |
| Corbar Grange Management Limited | Households | 1987 |
| Cordenhall Ltd | Transport & logistics | 2005 |
| Cornergate Limited | Professional & scientific | 2007 |
| Costessey Park Limited | Arts & recreation | 1997 |
| Count Contracts Limited | Construction | 1993 |
| Country Care Childrens Homes Ltd | Health & social care | 2001 |
| Country Care Development Services Ltd | Information & communication | 2019 |
| Country Construction and Management Ltd | Construction | 2022 |
| Country Pods Limited | Construction | 2021 |
| CP Sleep Diagnostics Limited | Other services | 2025 |
| CPA Group Limited | Real estate | 2026 |
| CPB Site Management Limited | Professional & scientific | 2015 |
| CPS Consulting Ltd | Other services | 2024 |
| Cpt.Pokemonhunter Ltd | Wholesale & retail | 2025 |
| CR Ultimate Sales Ltd | Wholesale & retail | 2022 |
| Craven Sayer Associates Limited | Professional & scientific | 1998 |
| Create Demand Ltd | Information & communication | 2022 |
| Create My Space Interior Design Limited | Other services | 2022 |
| Creative Heritage Consultants Limited | Administrative & support | 2005 |
| Creditways Limited | Real estate | 1947 |
| Crescent Cars (Buxton) Limited | Transport & logistics | 2003 |
| Crescent Scaffolding Ltd | Construction | 2016 |
| Cressbrook Hydropower Limited | Construction | 2012 |
| Crestbuild Properties Limited | Households | 1987 |
| Croft Park Residents Management Company Limited | Households | 2019 |
| Cronkstone Group Ltd | Agriculture & fishing | 2025 |
| Crossfit Buxton Ltd | Other services | 2017 |
| Crossview Training Ltd | Professional & scientific | 2022 |
| Crowther Key Limited | Real estate | 2014 |
| Csts NW Ltd | Administrative & support | 2017 |
| Current Standard Electric Limited | Construction | 2024 |
| Currie Marketing Limited | Wholesale & retail | 2008 |
| Curtis Medical Communications Limited | Professional & scientific | 2024 |
| CUT Throat Industries Ltd | Other services | 2016 |
| Cutty Wren Ltd | Professional & scientific | 2012 |
| CWC Beauty Ltd | Other services | 2016 |
| CX Heroes Ltd | Professional & scientific | 2025 |
| D Brindley Properties Limited | Real estate | 2024 |
| D Luxe Ltd | Administrative & support | 2025 |
| D.G. Bradshaw (Haulage) Limited | Transport & logistics | 1965 |