| South Mews Management Company Limited | Households | 2004 |
| South Yorkshire Padel Club Limited | Arts & recreation | 2025 |
| SP Fast Property Buyers UK Ltd | Real estate | 2020 |
| Spa Town Homes Limited | Real estate | 2026 |
| Spa Town Sparkles Ltd | Administrative & support | 2025 |
| Space Aliens Ltd | Arts & recreation | 2025 |
| Spar ROW Cottages Ltd | Real estate | 2025 |
| Spark Studio Ltd | Information & communication | 2026 |
| Spartan Comms Limited | Professional & scientific | 2008 |
| Spectrum Broadcast Limited | Information & communication | 2015 |
| Spring Water Mushrooms Buxton Limited | Agriculture & fishing | 2021 |
| Squair Homes Ltd | Hospitality | 2023 |
| ST. Moritz Limited | Hospitality | 2008 |
| St.Davids Assemblies Limited | Manufacturing | 1951 |
| Staden Electrical Holdings Limited | Professional & scientific | 2017 |
| Staden Lane Garage Limited | Wholesale & retail | 2008 |
| Stadenlaneautomotive Limited | Wholesale & retail | 2026 |
| Stancliffe Accounting Limited | Professional & scientific | 2005 |
| Stanedge Grange Butchery Limited | Wholesale & retail | 2013 |
| Stanedge Grange Limited | Professional & scientific | 2014 |
| Starpacks Limited | Education | 2008 |
| Start Over Movement Holdings Ltd | Information & communication | 2025 |
| Steele Court Limited | Households | 1973 |
| Steelworks Songs Ltd | Information & communication | 2023 |
| Stella Motors (High Peak) Limited | Wholesale & retail | 2006 |
| Stellar IT Services Ltd | Information & communication | 2022 |
| Steve Burns Business System Consultants Limited | Professional & scientific | 2015 |
| Steve Horner Engineering Ltd | Manufacturing | 2015 |
| Stewarts Corner Shop Limited | Wholesale & retail | 2015 |
| Stock My Bar Limited | Extraterritorial | 2022 |
| Stone PD Limited | Real estate | 2022 |
| Stone & Shires Limited | Real estate | 2023 |
| Stone Match Limited | Wholesale & retail | 2021 |
| Stoneglass Exterior Cleaning Ltd | Administrative & support | 2026 |
| Stonevada Limited | Real estate | 1997 |
| Stoney Knolls Children's Home Ltd | Health & social care | 2021 |
| Stratidel Limited | Administrative & support | 2008 |
| Strauss (International) Ltd | Other services | 2019 |
| Structural & Technical Systems Ltd. | Professional & scientific | 2002 |
| Studio 10 Kitchens Limited | Wholesale & retail | 2012 |
| STUMPUP4 Ltd | Financial services | 2017 |
| STUMPUP4SPORT Ltd | Financial services | 2017 |
| Success Concepts Limited | Professional & scientific | 2011 |
| Sunnyfields Caravan Park Ltd | Hospitality | 2026 |
| Supplement Station Ltd | Arts & recreation | 2025 |
| Sushi ZEN Boba Ltd | Hospitality | 2024 |
| Suzie Denton Consulting Ltd | Professional & scientific | 2021 |
| Swan House (Buxton) Limited | Households | 2004 |
| Swingmill Limited | Real estate | 1985 |
| Swofo Architects Ltd | Professional & scientific | 2016 |
| Sycamore Creative Ltd | Information & communication | 2005 |
| Synovia Clinic Ltd | Health & social care | 2025 |
| T Barber Groundworks Limited | Other services | 2024 |
| T&J Motors Ltd | Wholesale & retail | 2025 |
| T-Fab Limited | Construction | 2010 |
| T.B. & Sons Limited | Transport & logistics | 1991 |
| T.F.Jackson Properties Ltd | Agriculture & fishing | 2008 |
| Taddington Brewery Limited | Manufacturing | 2006 |
| Take a Peak Holiday Cottages Limited | Real estate | 2024 |
| Taking Back Your Power Community Interest Company | Education | 2023 |
| Talent Motto Limited | Professional & scientific | 2025 |
| Target Conformance Ltd. | Professional & scientific | 2016 |
| Tarka Controls Limited | Professional & scientific | 1971 |
| Tayarla Ltd | Manufacturing | 2020 |
| Taylor's Sky Limited | Professional & scientific | 2023 |
| TB Property HP Ltd | Real estate | 2024 |
| Tbryght Cleaning Services Ltd | Administrative & support | 2025 |
| TC Aggregates Online Limited | Wholesale & retail | 2012 |
| Team Firework Limited | Wholesale & retail | 2018 |
| Teams Research LLP | | 2026 |
| Tech Corner UK Limited | Wholesale & retail | 2018 |
| Temitola Wears Ltd | Wholesale & retail | 2025 |
| TEN Bears High Peak Limited | Hospitality | 2018 |
| Teresa Paul Consulting Ltd | Professional & scientific | 2024 |
| That Yorkshire LAD Ltd | Hospitality | 2025 |
| THE Agnew Film Company Limited | Other services | 2008 |
| THE Batter MAN Ltd | Hospitality | 2022 |
| THE Bradburys (Buxton) Limited | Real estate | 2024 |
| THE Buxton Crescent and Thermal Spa Heritage Trading Company Limited | Wholesale & retail | 2015 |
| THE Buxton Pudding Emporium Ltd | Wholesale & retail | 2023 |
| THE Cafe at the Green Pavilion Limited | Hospitality | 2014 |
| THE Carpet Gallery (Buxton) Ltd | Wholesale & retail | 2026 |
| THE Cavendish Kitchen (High Peak) Ltd | Hospitality | 2024 |
| THE Coach House Fish & Chip Shop Limited | Wholesale & retail | 2008 |
| THE Coal & LOG Store Limited | Wholesale & retail | 2020 |
| THE Content Group Studios Limited | Information & communication | 2025 |
| THE Contract Table Company Ltd | Wholesale & retail | 2015 |
| THE Corner Chippy Limited | Hospitality | 2020 |
| THE Creative Directive Ltd | Information & communication | 2013 |
| THE Driven Agency Limited | Professional & scientific | 2007 |
| THE Edwards Group Limited | Construction | 2021 |
| THE Enterprise Academy | | 2008 |
| THE Floral Collection Limited | Wholesale & retail | 2017 |
| THE Fool on the Hill Ltd | Administrative & support | 2013 |
| THE Freelance Florist Ltd | Professional & scientific | 2024 |
| THE Friends of Litton Village Limited | Other services | 2013 |
| THE Frog on the Bine Ltd | Hospitality | 2024 |
| THE Gates of Dawn Limited | Professional & scientific | 2023 |
| THE Greyhound Inn Warslow Ltd | Hospitality | 2024 |
| THE Hartington Cheese Shop Ltd | Wholesale & retail | 2020 |