| Spyglass Consultancy Services Limited | Information & communication | 2014 |
| Squiffy Media Ltd | Health & social care | 1987 |
| Squish Studios Limited | Education | 2023 |
| SR Asset Management Company Ltd | Financial services | 2016 |
| SR Payroll Bureau Limited | Professional & scientific | 2012 |
| SR Properties (Greenmount) Limited | Real estate | 2020 |
| SR1 Floor Screeders Limited | Administrative & support | 2023 |
| SRI JVT Consultant Ltd | Other services | 2024 |
| SRI JVT Ltd | Wholesale & retail | 2024 |
| Sriti Ltd | Hospitality | 2026 |
| Sriti Takeaway Ltd | Hospitality | 2023 |
| SRM Holdings Ltd | Financial services | 2025 |
| SRM Inspection Ltd | Professional & scientific | 2012 |
| SRM NW Limited | Wholesale & retail | 2023 |
| SRM Properties NW Ltd | Real estate | 2025 |
| SRP Inc Ltd | Real estate | 2023 |
| SRS Ultrasound Limited | Health & social care | 2020 |
| SRW Group Ltd | Wholesale & retail | 2024 |
| SS Enterprise Services Ltd | Wholesale & retail | 2026 |
| SS Packaging Limited | Administrative & support | 2024 |
| SSG Holdings Limited | Financial services | 2018 |
| SSI Private Ltd | Hospitality | 2021 |
| SSP Direct Limited | Administrative & support | 2010 |
| ST Aesthetics Ltd | Health & social care | 2020 |
| ST Ambrose Healthcare Ltd | Health & social care | 2016 |
| ST George's Shipping Limited | Wholesale & retail | 2024 |
| ST Helens Regeneration Limited | Construction | 2025 |
| ST Legal Services Ltd | Professional & scientific | 2021 |
| ST Teresa of Calcutta Catholic Academy Trust | Education | 2017 |
| ST. James's Hill Management Company Limited | Households | 2006 |
| Stacey'Sstyles Ltd | Other services | 2024 |
| Staff-Tech Recruitment Ltd | Administrative & support | 2025 |
| Stag Properties Managment Ltd | Real estate | 2026 |
| Stainthorpe Homes Limited | Construction | 2022 |
| Stakbodyrepair Ltd | Wholesale & retail | 2026 |
| Stamina Gymwear Limited | Wholesale & retail | 2025 |
| Stancastle Ltd | Financial services | 2024 |
| Stand Electrical NW Ltd | Construction | 2026 |
| Stand Property Investments Ltd | Real estate | 2026 |
| Standish Insurance Brokers Limited | Financial services | 2009 |
| Stannington Homes Ltd | Health & social care | 2025 |
| Star Autos Limited | Transport & logistics | 2000 |
| Star Clinical Ltd | Health & social care | 2025 |
| Stara Services Limited | Administrative & support | 2016 |
| Starlight Ultrasound Limited | Health & social care | 2019 |
| Station Works Limited | Real estate | 2013 |
| Staurtos Ltd | Wholesale & retail | 2025 |
| Stayd Limited | Real estate | 2026 |
| Staysavvyaccommodation Ltd | Hospitality | 2025 |
| Steak House & Beer BJ Ltd | Hospitality | 2024 |
| Stealth Strength & Fitness Limited | Arts & recreation | 2021 |
| Steam Clean Master Limited | Administrative & support | 2024 |
| Steinbach Properties Limited | Households | 2025 |
| Steinsberg Properties Limited | Real estate | 2009 |
| Stellar Pipework Plant Solutions Limited | Manufacturing | 2022 |
| Stephen Charles Architect Ltd | Professional & scientific | 2010 |
| Stephen LEE Driving Services Ltd | Transport & logistics | 2015 |
| Stephen Tabner Insurance Brokers Limited | Financial services | 2002 |
| Sterling Construction & Driveways Ltd | Construction | 2022 |
| Sterling Lock & Security (NW) Ltd | Other services | 2025 |
| Sterling Motors Group UK Ltd | Wholesale & retail | 2025 |
| Sterling Property Co. Limited | Real estate | 1996 |
| Steve Duckworth Electrical Limited | Construction | 2014 |
| Steve Tandy Art Limited | Arts & recreation | 2020 |
| Steven Harris Optical Company Limited | Wholesale & retail | 2005 |
| Stevenmorris Limited | Administrative & support | 2016 |
| Stewart's Property Development & Maintenance Limited | Construction | 2024 |
| STL Consultancy (UK) Ltd | Professional & scientific | 2023 |
| Stoc Services Ltd | Real estate | 2023 |
| Stone Hill Ltd | Wholesale & retail | 2023 |
| Stone Homes Limited | Real estate | 2017 |
| Stonearch Data Protection Limited | Professional & scientific | 2022 |
| Stonebridge (M/Cr) Limited | Construction | 2018 |
| Stonebridge Wealth Management Limited | Financial services | 2016 |
| Stonebrook Landscapes Limited | Administrative & support | 2008 |
| Stonebrook Mortgages Ltd | Administrative & support | 2017 |
| Stonecladuk Ltd | Construction | 2021 |
| Stoneholme Estates Limited | Real estate | 2016 |
| Stones Travel Limited | Administrative & support | 2020 |
| Stonewood Building & Joinery Ltd | Construction | 2020 |
| Stooker UK Ltd | Wholesale & retail | 2022 |
| Stop Inn Bury Ltd | Hospitality | 2025 |
| Stop Inn Pizza Ltd | Hospitality | 2026 |
| Store My Dress Limited | Administrative & support | 2022 |
| Story North Ltd | Arts & recreation | 2026 |
| STR8 Drop Ltd | Transport & logistics | 2024 |
| Strabo Limited | Extraterritorial | 2021 |
| Strada Associates Limited | Administrative & support | 2024 |
| Strata Communications Limited | Extraterritorial | 2008 |
| Strata Consultants Limited | Professional & scientific | 2025 |
| Strathalyn Management Company Limited | Households | 2004 |
| Stratton Estate Holdings Limited | Real estate | 2025 |
| Stratus Data Limited | Information & communication | 2020 |
| Strawberry Dreams Ltd | Hospitality | 2025 |
| Stray Horizons Ltd | Households | 2026 |
| Stream 123 Limited | Financial services | 2022 |
| Stream 456 Limited | Financial services | 2022 |
| Stream 789 Limited | Financial services | 2022 |
| Street Construction (Wigan) Limited | Wholesale & retail | 1975 |
| Street Eats Bury Ltd | Hospitality | 2024 |