| Sapere Aude Group Ltd | Professional & scientific | 2026 |
| Sapj Holdings Ltd | Arts & recreation | 2024 |
| Sapling Growth Consulting Ltd | Professional & scientific | 2026 |
| Saporem Ltd | Administrative & support | 2023 |
| Sapphire Brothers Ltd | Wholesale & retail | 2023 |
| Sapphire Crest Limited | Real estate | 2025 |
| Sapx Ltd | Professional & scientific | 2023 |
| Sara Homes Surrey Limited | Real estate | 2026 |
| Sarah Dugdale Logistics Ltd | Transport & logistics | 2026 |
| Sarah Gashi Advice Ltd | Financial services | 2024 |
| Sarah Place Accountants Ltd | Professional & scientific | 2013 |
| Sarah Western Limited | Other services | 2025 |
| Sarah's Montessori Nursery Limited | Education | 2024 |
| Sarauk Ebano Artistic Promotions Ltd | Arts & recreation | 2022 |
| Sarde Consultants Ltd | Professional & scientific | 2025 |
| Sarde Housing Ltd | Construction | 2026 |
| Sardelli Limited | Hospitality | 2022 |
| Sarder Trader's Ltd | Wholesale & retail | 2025 |
| Sarjem Ltd | Wholesale & retail | 2023 |
| Sarprest Holdings Limited | Financial services | 2019 |
| Sarwar Technologies Ltd | Information & communication | 2025 |
| Sasets Limited | Information & communication | 2012 |
| Sash Refurb Oxford Ltd | Construction | 2006 |
| Sasit Limited | Information & communication | 2017 |
| Sassela Ltd | Information & communication | 2017 |
| Sassela Property Ltd | Real estate | 2021 |
| Satis Global Ltd | Wholesale & retail | 2024 |
| Satrey Limited | Wholesale & retail | 2026 |
| Satsuma Services Ltd | Information & communication | 2025 |
| Sattoshi Ltd | Information & communication | 2026 |
| Sauced Condiments Ltd | Manufacturing | 2023 |
| Savannah Healthcare Ltd | Health & social care | 2011 |
| Savantill Limited | Information & communication | 2017 |
| Savasana MCR Ltd | Arts & recreation | 2023 |
| Save Greater Manchester's Green Belt Ltd | Professional & scientific | 2024 |
| Saving Circles Ltd | Information & communication | 2025 |
| Savoie Faire Holidays Limited | Hospitality | 2005 |
| Sawar Medicolegal Services Ltd | Health & social care | 2026 |
| Sawt Limited | Professional & scientific | 2021 |
| Saxham Developments Limited | Real estate | 2007 |
| Saxham Investments Limited | Real estate | 2004 |
| Saxham Medical Services Limited | Professional & scientific | 2018 |
| Saxham Properties Limited | Real estate | 2001 |
| Saxifrage Investments and Systems Ltd | Wholesale & retail | 2025 |
| Saxonace Limited | Wholesale & retail | 2019 |
| Saxondales Event Furniture Limited | Extraterritorial | 2016 |
| Saxstone Developments Limited | Information & communication | 2023 |
| SAY Nothing Studio Limited | Professional & scientific | 2024 |
| SAYIT4US CIC | Other services | 2026 |
| SB London Investments Limited | Real estate | 2017 |
| SB Properties London Limited | Real estate | 2017 |
| SBC LDN Ltd | Construction | 2017 |
| Sbia Limited | Information & communication | 2025 |
| Sbic Group for Business and Investment Consulting Limited | Financial services | 2026 |
| SBN IT Ltd | Other services | 2024 |
| SBS Scaffolding (Power) Limited | Construction | 2012 |
| Sbxtimmy Limited | Construction | 2024 |
| Scaffolding Erection Specialists Limited | Construction | 2016 |
| Scalagile Ltd | Information & communication | 2018 |
| Scarborough Ravine Ltd | Real estate | 2021 |
| Scarftitude Ltd | Wholesale & retail | 2021 |
| Scarlet Business Services | Professional & scientific | 2004 |
| Scarlet Consulting Services Limited | Administrative & support | 2008 |
| Scattered Castles Limited | Construction | 2025 |
| Scds Build 1 Ltd | Construction | 2021 |
| Scds Holdings UK Ltd | Construction | 2021 |
| Scds London Ltd | Real estate | 2016 |
| SCE Group for Import & Export and Travel Services Ltd | Wholesale & retail | 2022 |
| Scenemusicmedia Limited | Information & communication | 2024 |
| Scenic Productions Limited | Arts & recreation | 2013 |
| Scentleys Fragrance Ltd | Wholesale & retail | 2025 |
| Scentterrain Ltd | Wholesale & retail | 2025 |
| SCF Entertainment Ltd | Other services | 2025 |
| SCH Clinical Coding Services Limited | Information & communication | 2025 |
| Schedy Limited | Information & communication | 2025 |
| Schneider Solutions Ltd | Professional & scientific | 2023 |
| Scholar Humour Ltd | Information & communication | 2022 |
| School Break Explorers Ltd | Wholesale & retail | 2023 |
| School House Hargrave Ltd | Professional & scientific | 2022 |
| School of Plot Ltd | Wholesale & retail | 2023 |
| Schooled for Success Academy Ltd | Education | 2023 |
| Schwarzd Company Ltd | Wholesale & retail | 2021 |
| Scintillae Limited | Information & communication | 2018 |
| Scirocco Studios Ltd | Information & communication | 2026 |
| SCL Coaching Ltd | Education | 2026 |
| Sclicesmk Ltd | Hospitality | 2026 |
| SCO Concepts Limited | Wholesale & retail | 2025 |
| Scooptracker Ltd | Information & communication | 2025 |
| Scootertech Limited | Wholesale & retail | 2003 |
| Scopa Wise Limited | Professional & scientific | 2019 |
| Scopism Limited | Information & communication | 2016 |
| Scopum ET Finem Ltd | Administrative & support | 2017 |
| Scopus Index Journal Ltd | Information & communication | 2026 |
| Scorn Media Ltd | Information & communication | 2024 |
| Scorpio Film & TV Painting Ltd | Arts & recreation | 2012 |
| Scotswood Architecture Studio Ltd | Professional & scientific | 2019 |
| Scott Readman Concepts Ltd | Arts & recreation | 2016 |
| Scott Russell & Co Holdings Ltd | Financial services | 2021 |
| Scott Russell & Co Ltd | Professional & scientific | 2009 |
| Scotts Opticians (Bury ST Edmunds) Limited | Wholesale & retail | 2020 |