| S.B.Horses Limited | Agriculture & fishing | 2015 |
| S.E.S. Consultancy Limited | Professional & scientific | 2006 |
| S.J.P.Mortlock Limited | Agriculture & fishing | 1960 |
| S.K. Stopher Property Maintenance Limited | Administrative & support | 2003 |
| S.R.S.Aromatics Limited | Manufacturing | 1983 |
| S2 Logic Ltd | Information & communication | 2026 |
| SA Ethicguard Ltd | Information & communication | 2025 |
| SA Fuller Advocacy Limited | Other services | 2012 |
| SA Stock Brokers Limited | Administrative & support | 2007 |
| Sabb Design & Co. Ltd | Professional & scientific | 2025 |
| Sabikul Islam Ltd | Information & communication | 2025 |
| Sabre & Muri Estates Limited | Hospitality | 2024 |
| Saby Properties Ltd | Real estate | 2019 |
| SAC Locksmiths & Security Limited | Administrative & support | 2016 |
| Sachra Ltd | Administrative & support | 2014 |
| Sachtler Limited | Professional & scientific | 2009 |
| Sadan Plus Trading Co Ltd | Wholesale & retail | 2026 |
| Sadler Holdings Ltd | Real estate | 2024 |
| SAF GG Ltd | Wholesale & retail | 2018 |
| Safa Property Group Ltd | Construction | 2026 |
| Safe Bundle Ltd | Administrative & support | 2025 |
| Safe Foundry Ltd | Information & communication | 2026 |
| Safe Inception Limited | Other services | 2024 |
| Safe Step Surfaces Ltd | Construction | 2025 |
| Safe-Co Estates & Management Limited | Real estate | 2025 |
| Safety BOZ Ltd | Professional & scientific | 2025 |
| Safety Hangar Limited | Professional & scientific | 2023 |
| Safety Response Ltd | Wholesale & retail | 2023 |
| Saffa's Delight Ltd | Wholesale & retail | 2017 |
| Saffron FEN Place Management Ltd | Households | 2022 |
| Saffron Threads Ltd | Wholesale & retail | 2024 |
| Saga Property Development Ltd | Real estate | 2023 |
| Sagara Ltd | Health & social care | 2024 |
| Sages Properties Ltd | Real estate | 2025 |
| Sahan Ltd | Wholesale & retail | 2026 |
| Sahara Heating & Plumbing Ltd | Administrative & support | 2010 |
| Sahi Developments Ltd | Real estate | 2026 |
| SAI Anugrah Ltd | Health & social care | 2024 |
| SAI Star Properties Limited | Real estate | 2025 |
| Saif Health Limited | Health & social care | 2023 |
| Saint Developments Ltd | Construction | 2020 |
| Saintrose Ltd. | Manufacturing | 2021 |
| Saints Commercials Limited | Wholesale & retail | 1997 |
| Saiunes Limited | Wholesale & retail | 2022 |
| SAJ Masala Ltd | Hospitality | 2025 |
| Saje Ltd | Real estate | 2023 |
| Saka Recruitment Ltd | Administrative & support | 2026 |
| Sakoon Ltd | Administrative & support | 2023 |
| Sakura Japanese Food Ltd | Hospitality | 2018 |
| Sala Investments Limited | Financial services | 2023 |
| Salaamspot Limited | Information & communication | 2026 |
| Sales and Marketing Mastery Ltd | Information & communication | 2015 |
| Sales Growth Hub Limited | Administrative & support | 2025 |
| Sales Ranked Solution Limited | Wholesale & retail | 2026 |
| Sales Sell Ltd | Professional & scientific | 2025 |
| Salesforge Ltd | Professional & scientific | 2008 |
| Salford Double Glazing Ltd | Construction | 2018 |
| Salient Evidence Ltd | Professional & scientific | 2018 |
| Sally Campbell CTA Limited | Professional & scientific | 2016 |
| Salmas Vault Ltd | Wholesale & retail | 2023 |
| Salohub Ltd | Information & communication | 2026 |
| Salon Bett’S Ltd | Other services | 2025 |
| Salter-Orme Consultancy Limited | Professional & scientific | 2021 |
| Salts Mill Couriers Limited | Transport & logistics | 2021 |
| Salty Ventures Ltd | Wholesale & retail | 2021 |
| Salva Developments & Facilities Ltd | Construction | 2026 |
| Salvage Check Ltd | Information & communication | 2024 |
| Salvation Care Services Ltd | Health & social care | 2024 |
| Salún Ltd | Administrative & support | 2025 |
| SAM Bowers Roofing Limited | Construction | 2024 |
| SAM Jordan Cars Ltd | Wholesale & retail | 2011 |
| SAM Shaw Racing Limited | Arts & recreation | 2024 |
| SAM SW Ltd | Information & communication | 2025 |
| Sama Sama Studio Limited | Administrative & support | 2019 |
| Samdaar Limited | Information & communication | 2016 |
| Samdabell Ltd | Real estate | 2021 |
| Samlick Ltd | Wholesale & retail | 2014 |
| Samron Property Limited | Real estate | 2025 |
| Samson Autonomous Ltd | Manufacturing | 2025 |
| Samuel Camps Chiropractic Limited | Health & social care | 2021 |
| Samuel Cockman Ltd | Information & communication | 2019 |
| Samuel Olsen Associates Limited | Administrative & support | 2022 |
| Sancta Victa Ltd | Wholesale & retail | 2025 |
| Sanctum Beauty and Wellness Ltd | Education | 2023 |
| Sandar Limited | Information & communication | 2006 |
| Sandford Financial Planning Limited | Administrative & support | 2017 |
| Sandhaath Associates Ltd | Information & communication | 2012 |
| Sandialab Ltd | Administrative & support | 2026 |
| Sandpiper Asset Services Limited | Manufacturing | 2025 |
| Sandy Norman Ltd | Professional & scientific | 2019 |
| Sandy Select Ltd | Wholesale & retail | 2025 |
| Sanflawa Ltd | Professional & scientific | 2024 |
| Sang Medicine Ltd | Administrative & support | 2019 |
| Sanjay and Sonja Limited | Real estate | 2016 |
| Sanmos Medicus Ltd | Health & social care | 2026 |
| Sansom Kitchen Respray Ltd | Construction | 2024 |
| Sanstone Properties Ltd | Real estate | 2026 |
| Santa Monica Protection Ltd | Extraterritorial | 2010 |
| Santacruz Management Ltd | Households | 2017 |
| Saona Cleaning Services Limited | Administrative & support | 2007 |