| Stucco Stile Limited | Construction | 2022 |
| Studio Answers Limited | Wholesale & retail | 2014 |
| Studio Bisque Limited | Manufacturing | 2023 |
| Styler & Parfitt Ltd | Hospitality | 2025 |
| Stylus Music Limited | Professional & scientific | 2022 |
| Suemel Ltd | Professional & scientific | 2023 |
| Sukun Trading Ltd | Households | 2025 |
| Suli Construction Limited | Construction | 2026 |
| Sumera Parveen Ltd | Wholesale & retail | 2026 |
| Summer Realty Group Ltd | Professional & scientific | 2023 |
| Summer Realty Holdings Ltd | Real estate | 2023 |
| Summer Realty Ltd | Real estate | 2019 |
| Summit Survey Solutions Ltd | Professional & scientific | 2023 |
| Sunbrake Studio&Beauty Ltd | Other services | 2021 |
| Suncrest Retail Ltd | Wholesale & retail | 2025 |
| Sunrisemedia Ltd | Wholesale & retail | 2017 |
| Sunshine Decks Ltd | Construction | 2021 |
| Superb IT Solutions Ltd | Information & communication | 2018 |
| Supply Chain Champion Ltd | Professional & scientific | 2024 |
| Supply Chain Innovation Services Ltd | Administrative & support | 2012 |
| Sure Excellent Limited | Extraterritorial | 2023 |
| Sure Solve Ltd | Professional & scientific | 2024 |
| Sure Surveyors Ltd | Real estate | 2018 |
| Surestep Transport Ltd | Transport & logistics | 2025 |
| Surflink Systems Limited | Wholesale & retail | 2000 |
| Surgical Skills Centre Limited | Professional & scientific | 2012 |
| Survey, Design & Install Ltd | Information & communication | 2012 |
| Survivethestreets Limited | Wholesale & retail | 2025 |
| Susdel Ltd | Transport & logistics | 2013 |
| Sutcliffe Education Limited | Education | 2016 |
| Sutton Cleaning & Maintenance Limited | Administrative & support | 2025 |
| SVS Property Holding Ltd | Real estate | 2024 |
| SW & RRB Holdings Ltd | Real estate | 2020 |
| Swadlincote Minibus Hire Limited | Transport & logistics | 2025 |
| Swallowdale 1974 Limited | Extraterritorial | 2014 |
| Swan Enterprises (Derbyshire) Limited | Real estate | 2006 |
| Sweet LIL Things Ltd | Hospitality | 2025 |
| Sweetest Love Limited | Extraterritorial | 2012 |
| Swift Leaders Ltd | Wholesale & retail | 2014 |
| Swift-Cut Automation Limited | Manufacturing | 2011 |
| Swiftforge Ltd | Information & communication | 2026 |
| Swiftkeys 2025 Ltd | Households | 2025 |
| Swifts Trade Ltd | Wholesale & retail | 2021 |
| Swindale Associates Limited | Professional & scientific | 2004 |
| Swisspeaks Limited | Information & communication | 2000 |
| Switchsmart Compare Ltd | Professional & scientific | 2026 |
| Syago Ltd | Wholesale & retail | 2023 |
| Sycamore Lodge Bradford Limited | Health & social care | 2019 |
| SYLWMARC14 Ltd | Transport & logistics | 2014 |
| Symmetry IT Solutions Ltd | Information & communication | 2012 |
| Synesi Property Limited | Real estate | 2017 |
| Syntax AI Limited | Information & communication | 2025 |
| Systemation Euro Services Limited | Manufacturing | 2026 |
| T & MZ Limited | Construction | 2016 |
| T Gore Fabrications Ltd | Manufacturing | 2023 |
| T J Parry & Family Funeral Directors Ltd | Other services | 2018 |
| T MED Limited | Health & social care | 2018 |
| T P Smart Solutions Ltd | Wholesale & retail | 2025 |
| T Squared Communications Limited | Information & communication | 2017 |
| T&M CW Limited | Other services | 2019 |
| T&Y Investment Company Limited | Real estate | 2025 |
| T.C Heating and Plumbing Ltd | Construction | 2026 |
| T.K. Gould Ltd | Transport & logistics | 2015 |
| T.L. Darby (Sutton) Limited | Extraterritorial | 1976 |
| T.R.I. Limited | Wholesale & retail | 1981 |
| T2 Investments Limited | Professional & scientific | 2018 |
| T3W Ltd | Administrative & support | 2023 |
| TAB Estates (Midlands) Ltd | Real estate | 2025 |
| Tabara's Beauty Lounge Ltd | Other services | 2023 |
| Tabx Systems Ltd | Information & communication | 2018 |
| Taco Nation Limited | Hospitality | 2023 |
| Tacs Hire Ltd | Administrative & support | 2020 |
| Tacs Welfare Hire Ltd | Administrative & support | 2025 |
| Tadeo TS Ltd | Transport & logistics | 2020 |
| Tadh Solutions Limited | Information & communication | 2012 |
| TAJ Law Ltd | Professional & scientific | 2026 |
| Taka Props Limited | Construction | 2026 |
| Take AIM Limited | Hospitality | 2026 |
| Takumi Accountants Ltd | Professional & scientific | 2022 |
| Talbot Truck Services Ltd | Other services | 2012 |
| Talbyte Ltd | Information & communication | 2024 |
| Tallis Associates Limited Liability Partnership | | 2004 |
| Tamworth Leaflet Distribution Limited T/A DOR2DOR Tamworth Ltd | Professional & scientific | 2025 |
| Tamworth Plastering Ltd | Construction | 2017 |
| Tamworth Skip Hire Ltd | Extraterritorial | 2015 |
| Tamworth Street Management Lichfield Limited | Real estate | 2007 |
| TAP Recruitment Solutions Limited | Administrative & support | 2025 |
| Target Online Marketing Ltd | Professional & scientific | 2015 |
| TAS Engineering Ltd | Manufacturing | 2007 |
| Tatenhill Construction Services Ltd | Professional & scientific | 2011 |
| Tatenhill Governance Services Limited | Professional & scientific | 2012 |
| Tatm Properties Limited | Real estate | 2022 |
| Tattoo UK Club Ltd | Other services | 2023 |
| Taxbuddy Services Limited | Professional & scientific | 2017 |
| Taylor & Lloyd Properties Limited | Real estate | 2025 |
| Taylor Beaumont Developments Limited | Construction | 2024 |
| Taylor Beaumont Group Limited | Construction | 2024 |
| Taylor Beaumont Limited | Construction | 2021 |
| Taylor Construction Limited | Extraterritorial | 2021 |
| Taylor Event Hire Ltd | Administrative & support | 2025 |