| E + D Domestic Appliances Limited | Wholesale & retail | 2009 |
| E H Excavations Ltd | Construction | 2021 |
| E Howard & SON Limited | Transport & logistics | 2010 |
| E Howard Property Holdings Limited | Real estate | 2025 |
| E S Holdings Ltd | Financial services | 2004 |
| E-Oasis Tech Limited | Wholesale & retail | 2024 |
| E-Shop 365 Limited | Wholesale & retail | 2024 |
| E-Z Hire Lancs Ltd | Administrative & support | 2023 |
| E.B. Johnston Limited | Wholesale & retail | 1987 |
| E.D.S. Property Consulting Limited | Real estate | 2014 |
| E.L.D.A.R. Limited | Other services | 2012 |
| E.T.Riddiough (Sales) Limited | Wholesale & retail | 2001 |
| Eands Events Ltd | Hospitality | 2026 |
| Easistore 4 U (Colne) Limited | Transport & logistics | 2017 |
| East Fellgate Limited | Administrative & support | 2017 |
| East Lancashire Alliance CIC | Health & social care | 2020 |
| East Lancashire Construction Ltd | Construction | 2013 |
| East Lancashire Platers Limited | Professional & scientific | 1976 |
| East Lancashire Properties Ltd | Real estate | 2019 |
| East Lancs Care School Ltd | Professional & scientific | 2025 |
| East Lancs Carpets Ltd | Wholesale & retail | 2022 |
| East Lancs Diving Ltd | Arts & recreation | 2018 |
| East Midlands Roofing Solutions Ltd | Construction | 2019 |
| EASY2TRANSPORT Ltd | Transport & logistics | 2025 |
| EAT Grow Thrive Ltd | Administrative & support | 2015 |
| EB Consulting Services Limited | Professional & scientific | 2024 |
| EB Equestrian Ltd | Arts & recreation | 2025 |
| Ebo.Ai (UK) Ltd | Information & communication | 2018 |
| Ebuy Ltd | Wholesale & retail | 2025 |
| EC02 Enterprises Ltd | Water & waste | 2014 |
| Echelon Estates Group Ltd | Real estate | 2026 |
| Echo Web Limited | Information & communication | 2010 |
| Eco 4 Insulation Ltd | Wholesale & retail | 2022 |
| Eco 4 Measures Ltd | Wholesale & retail | 2023 |
| Eco Fluxi Ltd | Wholesale & retail | 2024 |
| Eco Green Studio Ltd | Professional & scientific | 2024 |
| Eco Inpower Ltd | Energy | 2024 |
| Eco Lite (NW) Ltd | Construction | 2017 |
| Eco Paper Box Ltd | Administrative & support | 2024 |
| Eco Revenue Limited | Other services | 2024 |
| Eco Specific Ltd | Construction | 2018 |
| Eco Surveys (NW) Ltd | Financial services | 2023 |
| Eco-Soar Ltd | Professional & scientific | 2024 |
| ECO54 Consultancy Ltd | Professional & scientific | 2024 |
| Ecobell Consulting Limited | Professional & scientific | 2015 |
| Ecom Empire Ltd | Wholesale & retail | 2019 |
| Ecomulch Limited | Extraterritorial | 2012 |
| Eddie Gill's Limited | Wholesale & retail | 2015 |
| Eddlestone UK Limited | Real estate | 1997 |
| Edelfaiz Ltd | Wholesale & retail | 2024 |
| Eden Creative Design & Marketing Ltd | Professional & scientific | 2012 |
| Edge House Developments Limited | Construction | 2006 |
| EDL John Quinn (Burnley) Ltd | Manufacturing | 2016 |
| EDS Catered Eats Limited | Hospitality | 2018 |
| Edspace (Accrington) Ltd | Education | 2020 |
| Edstart Burnley Ltd | Education | 2022 |
| Edstart Ribble Valley Ltd | Education | 2024 |
| Edugrp Ltd | Administrative & support | 2023 |
| Edusentials Limited | Education | 2008 |
| Edward Elizabeth Limited | Real estate | 2016 |
| Edwards DA Management Ltd | Hospitality | 2026 |
| EEM London Ltd | Hospitality | 2022 |
| EFS Boss Ltd | Real estate | 2007 |
| EFS Global Consulting Ltd | Transport & logistics | 2023 |
| EFS Global Holdings Ltd | Transport & logistics | 2022 |
| EFS Global Limited | Financial services | 2018 |
| EFS Global North East Limited | Transport & logistics | 2024 |
| EFS Investments Limited | Transport & logistics | 2020 |
| EFS Logistics Ltd | Transport & logistics | 1992 |
| EFS Traction Limited | Transport & logistics | 2007 |
| EFS Transport Ltd | Transport & logistics | 2022 |
| EFW Construction Ltd | Construction | 2024 |
| Eggzz Ltd | Hospitality | 2024 |
| Egyptian Linen Company Limited | Manufacturing | 1998 |
| Ejaz Bhutta Ltd | Wholesale & retail | 2025 |
| EKC Romsey Limited | Manufacturing | 2008 |
| Elas Land Solutions Ltd. | Construction | 2014 |
| Elderglow Care Ltd | Health & social care | 2025 |
| Eldon Street Garage (Preston) Ltd | Wholesale & retail | 2011 |
| Elec Developments Limited | Real estate | 2017 |
| Electrical Mechanical Facilities Ltd | Administrative & support | 2025 |
| Electron Records Limited | Wholesale & retail | 2002 |
| Elegance Soft Furnishings Ltd | Wholesale & retail | 2025 |
| Elementkarbon Limited | Professional & scientific | 2020 |
| Eleos Contract and Property Consulting Ltd | Professional & scientific | 2025 |
| Elevana Care Ltd | Health & social care | 2024 |
| Elevate Learning Hub Limited | Education | 2024 |
| Elevate Social Media Limited | Information & communication | 2023 |
| Elevated Socials Ltd | Professional & scientific | 2025 |
| ELEVEN27 Ltd | Hospitality | 2022 |
| Eliara Ltd | Construction | 2025 |
| Elite Coatings Inspection Services Limited | Other services | 2023 |
| Elite Coatings International Limited | Manufacturing | 2006 |
| Elite Control Services Limited | Professional & scientific | 2020 |
| Elite One Ltd | Professional & scientific | 2018 |
| Elite Picks Limited | Wholesale & retail | 2024 |
| Elite Property Solutions (UK) Limited | Real estate | 2008 |
| Elite Source Ltd | Wholesale & retail | 2025 |
| Elite Urban Homes Ltd | Real estate | 2026 |
| Elite Wholesale Traders Ltd | Wholesale & retail | 2025 |