| Davison.Estates Ltd | Real estate | 2025 |
| Davos Venues Limited | Transport & logistics | 2023 |
| Dawson Reproductions Limited | Manufacturing | 2003 |
| Dayvas Limited | Information & communication | 2020 |
| DB Garden and Tree Care Ltd | Other services | 2013 |
| Dd&A Electrical Ltd | Construction | 2022 |
| Delflor Ltd | Other services | 2020 |
| Denman-Ford Properties Limited | Real estate | 2024 |
| Denmark House Flat Management Ltd | Households | 2023 |
| DENT4YOU Ltd | Manufacturing | 2022 |
| Dentalessence @ Burgess Hill Ltd | Health & social care | 2025 |
| Dentalessence @ Haywardsheath Ltd | Health & social care | 2025 |
| Dentalessence @ Sompting Ltd | Health & social care | 2025 |
| Dentalessence @ Weybridge Ltd | Health & social care | 2025 |
| Dentalessence @ Worthing Ltd | Health & social care | 2025 |
| Derdes Limited | Wholesale & retail | 2020 |
| Deric S.Scott Limited | Extraterritorial | 1936 |
| Deshi Naga Ltd | Hospitality | 2019 |
| Designer Village Limited | Wholesale & retail | 2014 |
| Devit Ltd | Information & communication | 2016 |
| Devred Ltd | Information & communication | 2012 |
| Dewtree Property Management Limited | Households | 1984 |
| DGH Recruitment Ltd | Administrative & support | 1998 |
| Dglm Consulting Ltd | Information & communication | 2026 |
| DI Fazzari Ltd | Administrative & support | 2021 |
| Dickson Consultancy Ltd | Professional & scientific | 2022 |
| Didier Sicoit Limited | Wholesale & retail | 2006 |
| Digital Cafe Limited | Wholesale & retail | 2017 |
| Digitalsplat Limited | Information & communication | 2011 |
| Diligentchex Ltd | Professional & scientific | 2023 |
| Dimension Left Limited | Information & communication | 2020 |
| Dipi Solutions Ltd | Information & communication | 2019 |
| Direct Transport Southern Limited | Transport & logistics | 2018 |
| Ditchling Surveying Services Limited | Professional & scientific | 2014 |
| DJD Electrical Services Ltd | Construction | 2020 |
| Djms Hospitality Ltd | Professional & scientific | 2022 |
| DLC Properties Limited | Construction | 2015 |
| DNM Management Services Ltd | Administrative & support | 2023 |
| Doctor Pops Ltd | Information & communication | 2012 |
| Doctor Productions Ltd | Information & communication | 2016 |
| Doobrey Limited | Professional & scientific | 2004 |
| Dooriisan Limited | Wholesale & retail | 2024 |
| Dormers Farm Limited | Agriculture & fishing | 2017 |
| Dorsal Ltd | Construction | 2019 |
| Double Nine Limited | Administrative & support | 2005 |
| Doubledot Limited | Professional & scientific | 1990 |
| Downcast Apparel Ltd | Wholesale & retail | 2021 |
| Downs View Close Management Company Limited | Real estate | 2016 |
| Downscroft Properties Limited | Real estate | 2023 |
| Downsview and Parkview (Management) Limited | Households | 1995 |
| DP Aerials & Wi-Fi Ltd | Information & communication | 2025 |
| DR Kara Davey & Co Psychology Ltd | Health & social care | 2025 |
| DR Madeleine Kerr Limited | Health & social care | 2023 |
| DR Mark Jackson Ltd | Health & social care | 2018 |
| DR Street & Co Limited | Health & social care | 2018 |
| DR VFX Ltd | Information & communication | 2020 |
| DR Victoria Lukats Medical Limited | Health & social care | 2024 |
| Dragon JET Ltd | Professional & scientific | 2018 |
| Drawberry Sauce Limited | Professional & scientific | 2018 |
| DTC Property Services Ltd | Real estate | 2018 |
| DUE Timing Kettles Ltd | Wholesale & retail | 2026 |
| Dumpers 4 U Ltd | Construction | 2018 |
| Duncan James Sussex Limited | Health & social care | 2026 |
| Durial Ltd | Information & communication | 2022 |
| Durkan Geomatics Ltd | Professional & scientific | 2018 |
| Dustice Ltd | Administrative & support | 2025 |
| Dynamic Technical Concepts Holdings Limited | Professional & scientific | 2008 |
| Dynamic Technical Concepts Ltd | Information & communication | 2008 |
| E Turton's Therapy Ltd | Health & social care | 2022 |
| E.D.I. (Building) Limited | Construction | 1972 |
| Eaglet Media Limited | Information & communication | 2012 |
| EAO Limited | Wholesale & retail | 1962 |
| Early Doors Bars Ltd | Hospitality | 2012 |
| Eastbrook Developments Ltd | Construction | 2025 |
| Easylet Villas Limited | Hospitality | 2000 |
| EBP Offices Ltd | Real estate | 2006 |
| Ecofit Property Limited | Construction | 2013 |
| Ecotherm Energy Solutions Ltd | Construction | 2025 |
| Edenbrook Place (Blindley Heath) Management Company Limited | Households | 2009 |
| Edigital Creations Ltd | Wholesale & retail | 2012 |
| Edisson Investments Ltd | Financial services | 2014 |
| Edwards Heating Solutions Limited | Construction | 2024 |
| EES Engineering Limited | Manufacturing | 1980 |
| EGY Builds Limited | Other services | 2024 |
| EH Plumbing & Electrical Contractors Ltd | Construction | 2021 |
| EJA Property Limited | Real estate | 2014 |
| Ekam Dhanjal Limited | Hospitality | 2022 |
| Elastacloud Limited | Information & communication | 2012 |
| Eleanor ST John Ltd | Professional & scientific | 2022 |
| Elementary Signs Limited | Manufacturing | 2004 |
| Eleven Pro Consulting Limited | Arts & recreation | 2020 |
| ELF Holdings (UK) Limited | Water & waste | 2018 |
| Elizabeth Court (Victoria Road Horley) Residents Association Limited | Households | 1977 |
| Elizabeth House (East Grinstead) Management Company Limited | Households | 2016 |
| ELP (Sussex) Ltd | Professional & scientific | 2026 |
| Emachimbidza Limited | Agriculture & fishing | 2016 |
| Embarr Development Limited | Information & communication | 2014 |
| Embeo Limited | Real estate | 2025 |
| Embroider Direct Limited | Extraterritorial | 2024 |
| Emma Leeson Massage (ELM) Ltd | Other services | 2017 |