| Enviroloft Limited | Construction | 2020 |
| Environmental Earth Sciences International Limited | Water & waste | 2006 |
| Environmental Gain Limited | Professional & scientific | 2003 |
| Environmental Processing Solutions Limited | Mining & quarrying | 2016 |
| Environmental, Community & Workspace Facilities Limited | Information & communication | 1991 |
| Environments for Business Limited | Construction | 2010 |
| Enviropest Control Services Ltd | Administrative & support | 2002 |
| Envirotech Talent Ltd | Administrative & support | 2024 |
| Envisage Change Consulting Ltd | Professional & scientific | 2022 |
| Envoy Cars Limited | Administrative & support | 2013 |
| Enzojoly Ltd | Wholesale & retail | 2025 |
| Enzoxsvisuals Limited | Information & communication | 2023 |
| Eolith Limited | Information & communication | 2005 |
| EOS Medical Limited | Health & social care | 2011 |
| EP Healthcare Ltd | Health & social care | 2020 |
| EP Property Investment Limited | Administrative & support | 2020 |
| EP Surgical Ltd | Health & social care | 2017 |
| Epads Limited | Financial services | 2014 |
| Epata Community Housing C.I.C. | Hospitality | 2020 |
| EPC Bright Ltd | Professional & scientific | 2013 |
| EPC Constructions Ltd | Construction | 2023 |
| EPC Services Bristol Ltd | Professional & scientific | 2025 |
| EPC Services South West Limited | Construction | 2014 |
| EPD Equine Limited | Other services | 2013 |
| Ephemeral Productions Ltd | Information & communication | 2024 |
| Ephraimservices Limited | Health & social care | 2016 |
| Ephranexus Ltd | Wholesale & retail | 2025 |
| Epic Access Limited | Construction | 2018 |
| Epic Escapes Ltd | Administrative & support | 2024 |
| Epic Gym (Portishead) Ltd | Arts & recreation | 2025 |
| Epic Heating Ltd | Construction | 2014 |
| Epic Installations Ltd | Construction | 2024 |
| Epic Martial Arts Satellite Clubs Ltd | Arts & recreation | 2025 |
| Epic Sales Limited | Other services | 2017 |
| Epic Stone Masonry Southwest Ltd | Manufacturing | 2022 |
| Epic Toys Ltd | Wholesale & retail | 2023 |
| Epic Trading 2016 Limited | Wholesale & retail | 2016 |
| Epic Youth Community Interest Company | Health & social care | 2012 |
| Epic-Kick Ltd | Wholesale & retail | 2025 |
| Epicloud Ltd | Education | 2022 |
| Epie-Ngole & Sons Ltd | Health & social care | 2015 |
| Epigonsolutions Ltd | Professional & scientific | 2014 |
| Epimorphics Limited | Information & communication | 2009 |
| Epinal Limited | Manufacturing | 2020 |
| Epinephrine International Limited | Professional & scientific | 2015 |
| Epinephrine UK Limited | Hospitality | 2012 |
| Epinoy Holdings Ltd | Financial services | 2025 |
| Epinoy Investments Ltd | Real estate | 2024 |
| Epiphany in Care Limited | Health & social care | 2014 |
| Epiphany Prime Limited | Extraterritorial | 2016 |
| Epipharma Limited | Professional & scientific | 2006 |
| Epirus Investments Limited | Financial services | 2021 |
| Epoch Design Limited | Professional & scientific | 1995 |
| Epos Payment Solutions Limited | Information & communication | 2022 |
| Eposbuddy Limited | Information & communication | 2021 |
| Epping PPP Maintenance (Health) Services Limited | Construction | 2004 |
| Eppos Ltd | Extraterritorial | 2012 |
| EPS Building Services Limited | Extraterritorial | 1986 |
| Epsim Limited | Information & communication | 1986 |
| Epstein Auto Services Limited | Wholesale & retail | 2011 |
| EQ Equip Assist Ltd | Extraterritorial | 2025 |
| EQM 26 Ltd | Professional & scientific | 2025 |
| Equa Education Ltd | Education | 2025 |
| Equal Opportunity Limited | Health & social care | 2022 |
| Equal Resourcing Limited | Administrative & support | 2023 |
| Equal Right Ltd | Information & communication | 2016 |
| Equalium Limited | Professional & scientific | 2025 |
| Equalmotion Ltd | Information & communication | 2026 |
| Equanimator Ltd | Professional & scientific | 2020 |
| Equasy Enterprises Ltd | Professional & scientific | 2013 |
| Equdash Ltd | Information & communication | 2026 |
| Equestre Sport Ltd | Wholesale & retail | 2022 |
| Equi-Fit Elite Ltd | Wholesale & retail | 2021 |
| Equifino Ltd | Professional & scientific | 2021 |
| Equilibrium (Bristol) Ltd | Other services | 2019 |
| Equilibrium Industries Limited | Manufacturing | 2010 |
| Equilibrium Investments UK Limited | Financial services | 2025 |
| Equine Paddock Maintenance Limited | Administrative & support | 2014 |
| Equine Reflections CIC | Education | 2021 |
| Equinethos Limited | Agriculture & fishing | 2012 |
| Equinix (MA5) Limited | Administrative & support | 2019 |
| Equinix (Services) Limited | Administrative & support | 2000 |
| Equinix (UK) Enterprises Limited | Administrative & support | 2014 |
| Equinix (UK) Limited | Administrative & support | 1998 |
| Equinix Hyperscale 1 (LD11) Enterprises Limited | Administrative & support | 2021 |
| Equinix Hyperscale 1 (LD11) Limited | Administrative & support | 2018 |
| Equinix Hyperscale 1 (LD13) Limited | Administrative & support | 2019 |
| Equinix Hyperscale 1 (UK) Financing Limited | Administrative & support | 2019 |
| Equinix Hyperscale 2 (LDX) Limited | Administrative & support | 2021 |
| Equinox Ballooning Limited | Arts & recreation | 2014 |
| Equinox Games Limited | Manufacturing | 2025 |
| Equinox Legal Services Limited | Administrative & support | 2003 |
| Equinoxia GC Ltd | Transport & logistics | 2023 |
| Equiplay Ltd | Information & communication | 2025 |
| Equipment Move Engineering Ltd | Professional & scientific | 2021 |
| Equippers Church Bristol | Other services | 2007 |
| Equiptest (Holdings) Limited | Real estate | 2022 |
| Equiptest Compliance Ltd | Manufacturing | 2014 |
| Equiptest Limited | Professional & scientific | 2006 |
| Equitas Psychology Ltd | Administrative & support | 2025 |