| Solihull Hand Car Wash Ltd | Wholesale & retail | 2022 |
| Solihull Psychology LLP | | 2018 |
| Somero Ltd | Information & communication | 2018 |
| Sonority Design Limited | Professional & scientific | 2006 |
| Sooch Limited | Wholesale & retail | 2026 |
| Sosa Reliance Limited | Wholesale & retail | 2025 |
| Sound Junkies Limited | Wholesale & retail | 2023 |
| Southam Mini Metro Centre Ltd | Wholesale & retail | 2003 |
| Southdown Welding Inspection Limited | Professional & scientific | 2019 |
| SP. Couriers Limited | Extraterritorial | 2017 |
| SPARES4BMS Ltd | Wholesale & retail | 2023 |
| Sparkle Traders Ltd | Real estate | 2023 |
| Speak UP for US Foundation | Information & communication | 2023 |
| Spearstone Limited | Information & communication | 2002 |
| Specsafe Eyewear Ltd | Wholesale & retail | 2008 |
| Specstore (Brierley Hill) Ltd | Wholesale & retail | 2022 |
| Spectra Systems Limited | Information & communication | 2026 |
| Spectrum Building Envelopes & Facades Ltd | Construction | 2009 |
| Spectrum Building Envelopes Holdings Ltd | Financial services | 2016 |
| Speed Maxx Ltd | Wholesale & retail | 2018 |
| Speedysprint Couriers Ltd | Transport & logistics | 2025 |
| Spencer Reynolds Architecture Ltd | Construction | 2021 |
| Spinoutuk Limited | Arts & recreation | 2025 |
| Sports Bar & Grill Ltd | Hospitality | 2023 |
| Sports Health and Education Hub Ltd | Professional & scientific | 2025 |
| Springhill Court Property Management Ltd | Households | 2016 |
| Sprinkled With Hope Properties Ltd | Real estate | 2025 |
| SS Laser Solutions Ltd | Manufacturing | 2018 |
| SS Wholesale Ltd | Wholesale & retail | 2026 |
| Ssab Swedish Steel Limited | Manufacturing | 1961 |
| ST Pauls Capital Ltd | Real estate | 2026 |
| ST Valchanov Ltd | Transport & logistics | 2012 |
| ST. Anne's Management (Cheltenham) Limited | Households | 2004 |
| ST. Nicolas Limited | Wholesale & retail | 2014 |
| Staffordshire Crystal Ltd | Real estate | 1989 |
| Staffordshire Property Rentals Limited | Construction | 2026 |
| Staffs Homes Ltd | Real estate | 2025 |
| Staind Contracting Ltd | Transport & logistics | 2016 |
| Stalesudden Ltd | Wholesale & retail | 2019 |
| Standing Claims and Hire Ltd | Administrative & support | 2025 |
| Standout Balloons Limited | Wholesale & retail | 2021 |
| Standtrade Limited | Manufacturing | 1992 |
| Star Logistiks Limited | Transport & logistics | 2024 |
| Starcrest Estates Limited | Real estate | 2002 |
| Stardom Limited | Construction | 1993 |
| Start Simple Ltd | Professional & scientific | 2019 |
| Staticsupply Ltd | Wholesale & retail | 2024 |
| Stechwork Limited | Professional & scientific | 1978 |
| Steel Slitters (Sandwell) Ltd | Transport & logistics | 2016 |
| Steeltech Gym Installations Limited | Construction | 2025 |
| Stephen Bunting Limited | Arts & recreation | 2013 |
| Sterling Autohaus Ltd | Wholesale & retail | 2026 |
| Sterling Controls Limited | Administrative & support | 2022 |
| Sterling Group Solutions Limited | Wholesale & retail | 2023 |
| STERN77 Ltd | Transport & logistics | 2016 |
| Steven James Morgan Ltd | Real estate | 2019 |
| Stilecroft Properties Ltd | Real estate | 2019 |
| Stirchley Burger Property Holdings Limited | Financial services | 2021 |
| Stone Manor Commercials Ltd | Wholesale & retail | 2024 |
| Stoneview 1 Limited | Construction | 2021 |
| Stormshield Roofing (UK) Limited | Construction | 2013 |
| Stormshield Roofline Limited | Construction | 2023 |
| Stour Accounting Limited | Professional & scientific | 2012 |
| Stour Secure Ltd | Administrative & support | 2025 |
| Stour Shapes Limited | Manufacturing | 2002 |
| Stour Vale Holdings Ltd | Financial services | 2025 |
| Stourbridge Bespoke Buildings Limited | Manufacturing | 2019 |
| Stourbridge PO Ltd | Transport & logistics | 2026 |
| Stourbridge Sheds & Fencing Limited | Other services | 2018 |
| Stourport Motors Ltd | Wholesale & retail | 2024 |
| Stourtherm Ltd | Construction | 2004 |
| Stourton Court Services Limited | Water & waste | 1985 |
| Stratton Developments Ltd | Construction | 2021 |
| Streamline Classics Ltd | Wholesale & retail | 2020 |
| Streatery Catering Services Limited | Hospitality | 2024 |
| Structural Stairways Limited | Manufacturing | 1987 |
| Strut Pro Ltd | Professional & scientific | 2021 |
| Stuart Hingley Building Services Limited | Construction | 2013 |
| Style Commercial Services Limited | Construction | 2007 |
| Style Properties (Midlands) Limited | Real estate | 2012 |
| Stylish Developers Ltd | Real estate | 2025 |
| Stylish Garments Limited | Wholesale & retail | 2021 |
| Subra Limited | Real estate | 1993 |
| Sukhbir Bhamra Ltd | Wholesale & retail | 2022 |
| Summer Green Energy Solutions Limited | Construction | 2025 |
| Summerhill Packaging Limited | Administrative & support | 2016 |
| Summerhill Promotions Limited | Administrative & support | 2007 |
| Summit Retail Group Ltd | Wholesale & retail | 2026 |
| Sunnyjenny Ltd | Wholesale & retail | 2022 |
| Sunrise (CS) Ltd | Real estate | 2012 |
| Sunrise Medical (China) NO 1 Limited | Professional & scientific | 2011 |
| Sunrise Medical (UK) NO.1 Limited | Financial services | 2015 |
| Sunrise Medical Holdings Limited | Financial services | 2003 |
| Sunrise Medical Limited | Manufacturing | 1998 |
| Super Rise Services Limited | Professional & scientific | 2018 |
| Superchin 180 Ltd | Arts & recreation | 2016 |
| Superchin Properties Ltd | Real estate | 2018 |
| Supreme Beds Ltd | Wholesale & retail | 2022 |
| Sure Step Consulting Limited | Information & communication | 2014 |
| Surf and Turf Sprinklers and Irrigation Limited | Other services | 2025 |