| Servicesbysaroyas Ltd | Administrative & support | 2024 |
| SET Pace Midlands Ltd | Wholesale & retail | 2025 |
| SEW Your Soul Holdings Limited | Financial services | 2019 |
| SEW Your Soul Ltd | Arts & recreation | 2014 |
| SF Accountancy Services Limited | Professional & scientific | 2015 |
| SF and NF Holdings Ltd | Financial services | 2025 |
| SF Property Investors Ltd | Real estate | 2019 |
| SF UK Holdings Ltd | Financial services | 2024 |
| SFG Security & Electrical Installations Limited | Construction | 2004 |
| SFT Electrical Services Limited | Construction | 2015 |
| SH23 Properties Limited | Real estate | 2020 |
| Shaan Holdings Ltd | Real estate | 2024 |
| Shaggy Darts Limited | Arts & recreation | 2024 |
| Shah GEE Limited | Hospitality | 2021 |
| Shah Optometry Clinics Ltd | Wholesale & retail | 2021 |
| Shakey Logistics Limited | Administrative & support | 2023 |
| Shanitallstag Ltd | Administrative & support | 2019 |
| Shapelab Holdings Limited | Financial services | 2017 |
| Shapelab Laser Limited | Construction | 2018 |
| Shaw Brothers Limited | Construction | 2003 |
| Shaw Property Holdings Limited | Construction | 2020 |
| Shazhealthcare Ltd | Health & social care | 2019 |
| SHC Leisure Limited | Manufacturing | 2014 |
| SHD Coaching Ltd | Education | 2023 |
| Sheldons Bullion and Refinery Ltd | Financial services | 2026 |
| Shepherd Mouldings Limited | Manufacturing | 2016 |
| Shifnal Town Football Academy and Community Club Limited | Arts & recreation | 2023 |
| Shine Cleaning ( Midlands) Limited | Administrative & support | 2014 |
| Sholeldilles Ltd | Transport & logistics | 2017 |
| Shop BEY Ltd | Wholesale & retail | 2025 |
| Shop Hesellic Limited | Wholesale & retail | 2022 |
| Shopperden Ltd | Information & communication | 2023 |
| Shot in the Box Limited | Arts & recreation | 2023 |
| Show ME the Metrics Limited | Information & communication | 2013 |
| Shraloveress Ltd | Transport & logistics | 2017 |
| Shropshire Scale Co Ltd | Manufacturing | 2013 |
| Shuda Gotta Prenup Limited | Other services | 2023 |
| SI.THOMAS74 Ltd | Wholesale & retail | 2025 |
| Signature Capital (Midlands) Limited | Construction | 2017 |
| Silhouette Productions Limited | Extraterritorial | 2007 |
| Silver END Convenience Store Ltd | Wholesale & retail | 2017 |
| Silverend Service Station Limited | Wholesale & retail | 2016 |
| Simj EHV Cable Jointing Limited | Construction | 2016 |
| Simon JONES36 Ltd | Health & social care | 2026 |
| Simplelife Mobility Limited | Wholesale & retail | 2012 |
| Simply Avanti Limited | Professional & scientific | 2016 |
| Simply Grillicious Ltd | Hospitality | 2020 |
| Simply Maintenance Solutions Ltd | Construction | 2019 |
| Simply Recycling Limited | Manufacturing | 2009 |
| Simpsons Home Improvements Limited | Construction | 2023 |
| Sinclair Global Ltd | Wholesale & retail | 2022 |
| Sion Hill Court Management Company Limited | Other services | 2003 |
| Sipndrip Ltd | Hospitality | 2025 |
| SIX Pound Tees Ltd | Wholesale & retail | 2015 |
| Sixways Limited | Wholesale & retail | 2022 |
| Size Wize Ltd | Professional & scientific | 2026 |
| SJ Electrical ENG Ltd | Construction | 2026 |
| SJ Office Ltd | Extraterritorial | 2022 |
| SJB Foods Limited | Wholesale & retail | 2019 |
| SJJ Consulting Ltd | Professional & scientific | 2025 |
| Skin and Vitality Ltd | Wholesale & retail | 2022 |
| SKIRTING4LESS Ltd | Manufacturing | 2021 |
| Skylander Holdings Limited | Financial services | 2020 |
| Skyline Ductwork Ltd | Other services | 2019 |
| Skytek Media Limited | Information & communication | 2025 |
| SL7 Properties Ltd | Real estate | 2024 |
| Slade Tipton Limited | Arts & recreation | 1969 |
| Sled Holdings Ltd | Information & communication | 2025 |
| Slique Beauty Bar Ltd | Information & communication | 2025 |
| SLM Rejuvenate Ltd | Other services | 2025 |
| Sltsc Ltd | Real estate | 2025 |
| SM Group Limited | Hospitality | 2021 |
| SM Mortgage Services Ltd | Financial services | 2018 |
| Small Paws Veterinary Clinic Ltd | Professional & scientific | 2024 |
| Smart Boilers Limited | Construction | 2021 |
| Smart BTL Limited | Real estate | 2021 |
| Smart Culture Limited | Professional & scientific | 2020 |
| Smart Energy West Midlands Ltd | Professional & scientific | 2016 |
| Smart Local Shop DY5 Limited | Wholesale & retail | 2026 |
| Smart Protect Solutions Ltd | Information & communication | 2024 |
| Smart Saver Commercial Energy Ltd | Information & communication | 2025 |
| Smart Simple Repairs Ltd | Wholesale & retail | 2021 |
| Smart Vehicle Movements Limited | Administrative & support | 2017 |
| Smartohub Limited | Transport & logistics | 2025 |
| Smartrims Ltd | Wholesale & retail | 2012 |
| Smarts TS Limited | Transport & logistics | 2025 |
| SME Synergy Group Limited | Financial services | 2015 |
| SME Transport Solutions Ltd | Transport & logistics | 2023 |
| Smilla Holmberg Limited | Arts & recreation | 2026 |
| SMV Promotions Limited | Arts & recreation | 2025 |
| Snappy Barber Brierly Hill Ltd | Other services | 2023 |
| Snowflash Ltd | Wholesale & retail | 2018 |
| Social Care Matters Ltd | Health & social care | 2015 |
| Sofa Sense Ltd | Wholesale & retail | 2022 |
| Sofa-Tech (Dudley) Limited | Other services | 2013 |
| Soha's Waterfront Ltd | Hospitality | 2022 |
| Solar Mounting and Roofing Technologies Limited | Manufacturing | 2023 |
| Solarstone Music Limited | Information & communication | 2011 |
| Soley Customs Ltd | Administrative & support | 2020 |
| Solihull Climate Solutions Limited | Energy | 2019 |