| Cube Media Limited | Administrative & support | 2022 |
| Cubed Spirits Ltd | Wholesale & retail | 2021 |
| Cunningham Holdings (Yorkshire) Limited | Real estate | 2022 |
| Currantberry Barns Ltd | Hospitality | 2019 |
| Custodial Installation Services Ltd | Construction | 2012 |
| CW Chapman & SON Ltd | Agriculture & fishing | 2011 |
| Cybanet Ltd | Information & communication | 2025 |
| Cyber Skills Ltd | Education | 2023 |
| D & B Car and Commercials Limited | Wholesale & retail | 2006 |
| D & H Joinery and Building Ltd | Construction | 2018 |
| D & L Dowson Ltd | Real estate | 2026 |
| D & S Fleming Limited | Construction | 2003 |
| D a Holden Limited | Construction | 2003 |
| D B Lount & Sons Limited | Construction | 2014 |
| D Brown Roofing Limited | Construction | 2009 |
| D R Construction (NY) Limited | Construction | 2007 |
| D V Renewables Limited | Professional & scientific | 2010 |
| D&A Design and Build Ltd | Construction | 2021 |
| D&S Blinds (Yorkshire) Ltd | Manufacturing | 2023 |
| D&T Properties (Yorkshire) Limited | Real estate | 2025 |
| D.C. Roofing and Solar Ltd | Construction | 2025 |
| D.J. Horsley (Bridlington) Limited | Wholesale & retail | 1976 |
| D.R.E.W. Logistics Limited | Administrative & support | 2020 |
| D.W. Design Limited | Professional & scientific | 2003 |
| Dagakom Limited | Real estate | 2025 |
| Dalby Bike Barn Limited | Administrative & support | 2012 |
| Daloputs Ltd | Wholesale & retail | 2025 |
| Daly Caravans Limited | Extraterritorial | 2009 |
| Daly Holiday Parks Limited | Hospitality | 2022 |
| Daly Leisure Limited | Hospitality | 2009 |
| Daly Leisure Parks Limited | Extraterritorial | 2022 |
| Daneswood Caravan Storage Ltd | Hospitality | 2015 |
| Danny Neal Plumbing & Bathrooms Limited | Construction | 2024 |
| Dappa Desserts Ltd | Hospitality | 2025 |
| Data Recovery UK Ltd | Information & communication | 2025 |
| David Botham Transport Ltd | Transport & logistics | 2024 |
| David Eblet Heating Services Limited | Construction | 2026 |
| David R Boyne Property Solutions Limited | Real estate | 2008 |
| Davis House Furnishers Ltd | Wholesale & retail | 2006 |
| DB Collins Ltd | Hospitality | 2019 |
| DBL Homes Limited | Real estate | 2023 |
| DC Property Sourcing & Investments Ltd | Real estate | 2024 |
| Dean Lount Limited | Extraterritorial | 2022 |
| Deany Fabrics Ltd | Wholesale & retail | 2016 |
| Deborah Hale MBE Limited | Administrative & support | 2021 |
| Deeming Holdings Ltd | Hospitality | 2023 |
| Deepdale (Scarborough) Ltd | Real estate | 2018 |
| Deli Supplies Limited | Wholesale & retail | 2015 |
| Delsom Limited | Construction | 1954 |
| Denbeck Limited | Administrative & support | 2012 |
| Descom Marketing Limited | Professional & scientific | 2015 |
| Design Formula Ltd | Professional & scientific | 2025 |
| Destination Old Town CIC | Other services | 2023 |
| Detech Europe Limited | Manufacturing | 2003 |
| Devious Records Ltd | Manufacturing | 2019 |
| DGA Products Limited | Administrative & support | 2007 |
| DH Donuts Ltd | Hospitality | 2017 |
| Digwell Limited | Extraterritorial | 1992 |
| Direct Building & Joinery Limited | Construction | 2019 |
| Direct Flooring Suppliers Limited | Wholesale & retail | 2004 |
| Direct Works Group Limited | Professional & scientific | 2023 |
| Discount Carpets 4 Less Store Ltd | Wholesale & retail | 2017 |
| Discounted Furniture Ltd | Wholesale & retail | 2024 |
| Dixon & Associates Ltd | Construction | 2007 |
| DJ Morgan Plant Ltd | Construction | 2022 |
| DMC Contracting Services Ltd | Construction | 2023 |
| DNR Security Services Ltd | Administrative & support | 2026 |
| Dodgson Properties Limited | Real estate | 1958 |
| Donnybrook Property Management Limited | Households | 2023 |
| Donuts & Strawberries Limited | Hospitality | 2026 |
| Dotterel Ledger Ltd | Hospitality | 2026 |
| Dprintclothing Ltd | Manufacturing | 2023 |
| DRC Plant Limited | Construction | 2015 |
| Driffield GAS Services Limited | Manufacturing | 2007 |
| Driffield Padel Court Limited | Arts & recreation | 2026 |
| Driving Intentions Ltd | Extraterritorial | 2013 |
| Drumshack (Bridlington) Ltd | Hospitality | 2025 |
| DRW Services (Yorkshire) Limited | Transport & logistics | 2016 |
| DS GAS & Building Services Ltd | Construction | 2024 |
| Dsdf Limited | Hospitality | 2020 |
| Dsksj Publishing Ltd | Professional & scientific | 2020 |
| Duncan Wilkie Limited | Other services | 2023 |
| E G Atkinson Builders Limited | Construction | 2003 |
| E-Modular Limited | Construction | 2016 |
| E.D.P. Safety and Management Solutions Limited | Professional & scientific | 2009 |
| E.Y Farming Limited | Agriculture & fishing | 2023 |
| Eagle Lines Brid Ltd | Transport & logistics | 2023 |
| Eaglespot Limited | Other services | 1986 |
| East Coast Auto Service Limited | Wholesale & retail | 2003 |
| East Coast Excursions Ltd | Transport & logistics | 2022 |
| East Coast Geospatial Intelligence Solutions Limited | Information & communication | 2012 |
| East Coast Hospitality Group Ltd | Hospitality | 2025 |
| East Coast Property Lettings Limited | Real estate | 2024 |
| East Coast Rentals Ltd | Real estate | 2023 |
| East Coast Roofing and Sons (Yorkshire) Limited | Construction | 2020 |
| East Coast Seaside Properties Limited | Real estate | 2020 |
| East Coast Window Doctor Limited | Construction | 2021 |
| East END GAS Ltd | Wholesale & retail | 2011 |
| East Huntow Farm Limited | Agriculture & fishing | 2008 |
| East Mini Piling Ltd | Construction | 2024 |