| EL Property & Development Ltd | Real estate | 2022 |
| Elachi Bridgwater Limited | Hospitality | 2021 |
| Elaine Godley Limited | Administrative & support | 2016 |
| Elbitrans Ltd | Transport & logistics | 2015 |
| Eleb Group Ltd | Transport & logistics | 2022 |
| Elecsis Limited | Manufacturing | 2001 |
| Electrified Automation Limited | Administrative & support | 2020 |
| Electro (South West) Limited | Wholesale & retail | 2006 |
| Elegance Hair Studio Limited | Other services | 2023 |
| Elevate Construct Ltd | Construction | 2025 |
| Elevate Contracting Solutions Limited | Construction | 2025 |
| Eli's Rose & Crown Ltd | Hospitality | 2021 |
| Elimone Ltd | Manufacturing | 2024 |
| Elite Dairy Services Ltd | Manufacturing | 2013 |
| Elite Mobile Hub Ltd | Wholesale & retail | 2026 |
| Elite Properties Kefalonia Limited | Real estate | 2020 |
| Ellick & Hughes Construction Ltd | Construction | 2025 |
| Ellick & Hughes Developments Ltd | Real estate | 2023 |
| Ellick Properties Limited | Real estate | 2015 |
| EMD Commercial Ltd | Professional & scientific | 2000 |
| Emerald Investments (SW) Ltd | Real estate | 2024 |
| Emi-Joy Properties Limited | Real estate | 2025 |
| Emos 68 Ltd | Other services | 2026 |
| Empire Building Services and Landscaping Ltd | Construction | 2023 |
| Empire Racing Cars Limited | Manufacturing | 2015 |
| Empower Bridgwater Ltd | Other services | 2024 |
| Emr-Direct Ltd | Wholesale & retail | 2013 |
| Eng-Sw Ltd | Administrative & support | 2010 |
| Engineering NO7 Ltd | Manufacturing | 1995 |
| English Origins Limited | Wholesale & retail | 2011 |
| English Rural Action Limited | Extraterritorial | 2006 |
| Enmore Park Golf Club Limited | Arts & recreation | 2015 |
| Enoto Limited | Households | 2008 |
| Enso Head Spa Limited | Other services | 2025 |
| Entr'Acte Youth Company CIC | Arts & recreation | 2023 |
| Envirocare Services Limited | Extraterritorial | 1990 |
| Eoptimize Ltd | Information & communication | 2023 |
| Equi-Librium Coaching and Therapy CIC | Health & social care | 2024 |
| Equine Performance Ltd | Agriculture & fishing | 2011 |
| Erjus Ltd | Hospitality | 2018 |
| Erwin Rhodes (Skips) Limited | Water & waste | 2016 |
| Esmt Services Ltd | Health & social care | 2018 |
| Especially ME Limited | Other services | 2017 |
| Esra Food Centre Limited | Wholesale & retail | 2026 |
| Essential Foot and Body Care Limited | Wholesale & retail | 2020 |
| Ethica Environ Ltd | Agriculture & fishing | 2024 |
| Etitibarbershop Limited | Other services | 2025 |
| ETJ Holdings Ltd | Financial services | 2024 |
| ETJ Investments Ltd | Real estate | 2025 |
| Europe Food Trading Ltd | Wholesale & retail | 2023 |
| European Food Somerset Ltd | Wholesale & retail | 2018 |
| Evans Fabrications Limited | Manufacturing | 2013 |
| Evans Studio Ltd | Professional & scientific | 2025 |
| Event Attractions Holdings Ltd | Financial services | 2020 |
| Event Attractions Limited | Arts & recreation | 2013 |
| Event Lighting Sound & AV Limited | Construction | 2015 |
| Event Sparks Cable Recycling Limited | Water & waste | 2021 |
| Event Sparks Limited | Arts & recreation | 2018 |
| Everett Logistics Limited | Transport & logistics | 2018 |
| Evermore Holdings Limited | Financial services | 2024 |
| Evermore Property Group Limited | Real estate | 2024 |
| Everstrong Driveways and Roofing Ltd | Construction | 2025 |
| Everstrong Driveways Ltd | Construction | 2024 |
| Everything I. D. Limited | Professional & scientific | 2008 |
| Evolution Equine Limited | Extraterritorial | 2019 |
| Evolution Farm Vets Limited | Extraterritorial | 2008 |
| Evolution Vets Ltd | Professional & scientific | 2019 |
| Evolve Health & Fitness Ltd | Arts & recreation | 2024 |
| Evoq Food Limited | Hospitality | 2025 |
| Ewelina & Paul's Prospect Properties. Ltd | Real estate | 2022 |
| Exact Accounting Solutions Limited | Financial services | 2013 |
| Excellence Yacht Agency Ltd | Administrative & support | 2025 |
| Excelsior Development Technologies Ltd | Education | 2018 |
| Excess Solutions Ltd | Transport & logistics | 2022 |
| Exhibition Plinths Limited | Manufacturing | 2012 |
| Exhibuit Solutions Limited | Information & communication | 2019 |
| Exmouth Investments Limited | Professional & scientific | 2011 |
| Exmouth Management Limited | Real estate | 2011 |
| EXO Projects Limited | Professional & scientific | 2017 |
| Expert Automotive Solutions Limited | Administrative & support | 2021 |
| Expert Ice an Intensive Courses Experts Limited | Education | 2020 |
| Express Distribution Park Ltd | Construction | 2021 |
| Express Park Buxton Limited | Real estate | 2009 |
| Exssl (Holdings) Limited | Financial services | 2017 |
| Exstore Limited | Administrative & support | 2008 |
| Extinguish Ltd | Public administration | 2016 |
| F.G.Jeanes & SON Limited | Agriculture & fishing | 1960 |
| F28 Print Ltd | Manufacturing | 2025 |
| Face Co Aesthetics Ltd | Health & social care | 2022 |
| Fair Build Manufacturers Ltd | Manufacturing | 2026 |
| Fairbairn Limited | Professional & scientific | 1982 |
| Fairfax Electrical Services Ltd | Construction | 2025 |
| Fairview Europe (Holdings) Limited | Financial services | 2026 |
| Fairview Europe Ltd | Wholesale & retail | 2017 |
| Fancy Fish and Chips Limited | Hospitality | 2022 |
| Farm and Traction Services Limited | Agriculture & fishing | 2017 |
| Farm Water Limited | Agriculture & fishing | 2019 |
| Farmec Hire Centre Limited | Administrative & support | 2004 |
| Farr's Fish and Chips (North) Ltd | Hospitality | 2021 |
| Farr's Fish and Chips (South) Ltd | Hospitality | 2021 |