| DJW Electrical Services SW Limited | Construction | 2015 |
| DK Gray Limited | Wholesale & retail | 2011 |
| DLR (Chapel) Developments Limited | Real estate | 2019 |
| DLR (Rentals) Limited | Real estate | 2019 |
| DLR Group Limited | Construction | 2019 |
| DM Decorators & Property Maintenance Ltd | Construction | 2019 |
| DM Machinery Limited | Manufacturing | 2025 |
| Dmcm Property Services Ltd | Construction | 2024 |
| Dobeers Groundworks Limited | Construction | 2020 |
| Dodden Limited | Construction | 2008 |
| Doghead Designs Limited | Arts & recreation | 2024 |
| Dogs Day OUT Bridgwater Ltd | Agriculture & fishing | 2017 |
| Dominic Construction Group Ltd | Construction | 2026 |
| DON Media Ltd | Professional & scientific | 2025 |
| Dorofteigtn Limited | Construction | 2024 |
| Dosticouk Ltd | Wholesale & retail | 2025 |
| Douai Gardens Management Limited | Real estate | 2020 |
| Double Brace Ltd | Information & communication | 2013 |
| Dovecote House Investments Limited | Wholesale & retail | 2022 |
| Down Farm Estate Ltd | Households | 2026 |
| DP Trade Ltd | Wholesale & retail | 2026 |
| DR Andrew Skyrme-Jones Limited | Health & social care | 2018 |
| DR Chris Salway Ltd | Health & social care | 2024 |
| DR John Buckmaster Medical Services Limited | Health & social care | 2015 |
| DR Karen Luyt Ltd | Health & social care | 2016 |
| DR MWM Upton Ltd | Health & social care | 2011 |
| Dragonfly Films Ltd | Information & communication | 2020 |
| Dragos Cotinghiu Ltd | Health & social care | 2022 |
| Draper Biomass LLP | | 2025 |
| Dream Garden Builds Ltd | Construction | 2023 |
| Dreamweave UK PTY Limited | Wholesale & retail | 2022 |
| Drews UK Limited | Wholesale & retail | 2008 |
| Driving Renewable Energy Adaptation and Mitigation (Dream) Ltd | Financial services | 2025 |
| Drone South West Limited | Professional & scientific | 2023 |
| Drpcrd Limited | Professional & scientific | 2020 |
| Dryad GIN Ltd | Manufacturing | 2021 |
| DSB Housing Ltd | Real estate | 2025 |
| DSC Event Catering Limited | Hospitality | 2019 |
| DSD Auto ID Supplies Limited | Administrative & support | 2009 |
| DSD Property Management Ltd | Real estate | 2023 |
| Dslg Steel Storage Ltd | Transport & logistics | 2025 |
| DSM Independent Land Rovers Limited | Wholesale & retail | 2017 |
| DSM Motors Limited | Wholesale & retail | 2015 |
| DTW Air-Conditioning and Refrigeration Limited | Manufacturing | 2022 |
| Dube Medical Care Ltd | Health & social care | 2025 |
| Dumnonia Limited | Construction | 2020 |
| Dunnet Local Ltd | Wholesale & retail | 2026 |
| Dunroamin VDL Ltd | Real estate | 2024 |
| Duntech Holdings Limited | Professional & scientific | 2014 |
| Durleigh Automotive Limited | Wholesale & retail | 2019 |
| Durleigh Automotive Vehicle Repair Centre Ltd | Wholesale & retail | 2023 |
| Durra Steel Fixers Ltd | Construction | 2023 |
| DVS Express Limited | Transport & logistics | 2024 |
| DX Global Holdings Limited | Financial services | 2023 |
| Dyana International Mini Market Limited | Wholesale & retail | 2025 |
| Dynamic Efficiency Ltd | Professional & scientific | 2018 |
| Dynamic Solutions (South West) Limited | Construction | 2004 |
| Dzpro Limited | Transport & logistics | 2024 |
| E & H Drylining & Plastering (South West) Ltd | Construction | 2003 |
| E R Attractions Limited | Hospitality | 2026 |
| E Y Maintenance Ltd | Construction | 2025 |
| E&A Delivery Services Ltd | Transport & logistics | 2019 |
| E&D Leisure Ltd | Arts & recreation | 2022 |
| E&R Catering Ltd | Hospitality | 2020 |
| E-Clips Hair & Beauty Limited | Other services | 2013 |
| E.Bouchier Agricultural Machinery Ltd | Manufacturing | 2026 |
| Eagle Finance Limited | Professional & scientific | 1999 |
| EAJ Properties Limited | Real estate | 2025 |
| Earthy Properties Ltd. | Real estate | 2017 |
| EAS Bloodstock Ltd | Agriculture & fishing | 2022 |
| East Anglia Monitoring Ltd | Professional & scientific | 2010 |
| East Quay Car Sales (South West) Limited | Wholesale & retail | 2003 |
| East Quay Vision Limited | Health & social care | 2009 |
| East Stoke Farm Limited | Agriculture & fishing | 1960 |
| Easton Kebabs Limited | Hospitality | 2025 |
| Easton Mini Market Limited | Wholesale & retail | 2024 |
| Easy Renewables Services Ltd | Construction | 2022 |
| EAT Drink Escape Ltd | Hospitality | 2013 |
| Eating Disorder Recovery Ltd | Professional & scientific | 2022 |
| Ebsary Engineering Ltd | Professional & scientific | 2018 |
| Ec&S Ltd | Wholesale & retail | 2025 |
| Eco Building SW Limited | Administrative & support | 2016 |
| Eco Energy Commercial Limited | Water & waste | 2018 |
| Eco Energy Utility Limited | Administrative & support | 2015 |
| Eco Office Furniture Ltd | Wholesale & retail | 2025 |
| Eco Tuning Limited | Wholesale & retail | 2015 |
| Ecotronic Ltd | Professional & scientific | 2008 |
| EDD Food Limited | Hospitality | 2020 |
| Edel Healthcare Limited | Health & social care | 2014 |
| Eden Realty SW Limited | Construction | 2025 |
| Edington Properties Limited | Real estate | 1964 |
| Educating Safely LLP | | 2012 |
| Edurecover Solutions Ltd | Professional & scientific | 2021 |
| EFO Property Management Limited | Real estate | 2026 |
| Egret House Developments Limited | Administrative & support | 2010 |
| EHB Engineering Ltd | Manufacturing | 2010 |
| EJ Hire Ltd | Administrative & support | 2024 |
| EJR Industry College Engagement Ltd | Education | 2022 |
| EL Greco Barber Lounge Limited | Other services | 2026 |
| EL Padrino Garage Ltd | Wholesale & retail | 2026 |