| Somnus Sleep Ltd | Wholesale & retail | 2025 |
| Son's of Sethi Limited | Other services | 2024 |
| Sonali Business Centre UK Limited | Professional & scientific | 2018 |
| Sonalis Ltd | Real estate | 2014 |
| Sondia Group Limited | Financial services | 2025 |
| Sondia Lighting Limited | Manufacturing | 2016 |
| Sonhos Interiors Ltd | Wholesale & retail | 2022 |
| Soni Foods Limited | Hospitality | 2016 |
| Sonic Direct Holdings Limited | Financial services | 2025 |
| Sonic Megastore Limited | Wholesale & retail | 2009 |
| Sonic Plumbing and Electrical Limited | Construction | 2019 |
| Sonno Group Limited | Manufacturing | 2021 |
| Sonno Vista Ltd | Wholesale & retail | 2026 |
| Sooltan Steak House Ltd | Hospitality | 2025 |
| SOOLTANBD5 Ltd | Hospitality | 2024 |
| Soopergeneralstore Limited | Wholesale & retail | 2018 |
| Soothill Convenience Store & OFF Licence Limited | Wholesale & retail | 2019 |
| Sophia Pharm Ltd | Health & social care | 2025 |
| Sophie Jewellers Ltd | Wholesale & retail | 2021 |
| Sophie Pubs Limited | Hospitality | 2019 |
| Sophie's Travel Ltd | Transport & logistics | 2023 |
| Sophistyx Computing Ltd | Information & communication | 2001 |
| Sopranos Cafe Bistro Ltd | Hospitality | 2019 |
| Sorm Studios Ltd | Information & communication | 2012 |
| Sorted Church | Other services | 2010 |
| SOS Building Contractors Ltd | Construction | 2023 |
| SOS Recovery Limited | Transport & logistics | 2000 |
| SOS Rescue Limited | Other services | 2018 |
| SOS Security Services Limited | Administrative & support | 1999 |
| Sosa Developments Ltd | Real estate | 2020 |
| Souk & Savor Ltd | Hospitality | 2024 |
| Souk AL Arabi Limited | Wholesale & retail | 2021 |
| Souk Ltd | Other services | 2026 |
| Soukoun Services Limited | Hospitality | 2025 |
| Soul & Shade Tattoo Studio Ltd | Other services | 2025 |
| Soul Bars Limited | Hospitality | 2018 |
| Soul Business Empires Ltd | Professional & scientific | 2024 |
| Soul Sports Ltd | Wholesale & retail | 2025 |
| Soulasia Live Events Ltd | Administrative & support | 2021 |
| Sound Accommodation Ltd | Real estate | 2024 |
| Sound Education Limited | Other services | 2008 |
| Sound Hearts Connected CIC | Education | 2025 |
| Source Centre Limited | Wholesale & retail | 2025 |
| Source Clean Ltd | Administrative & support | 2025 |
| Source Globe Limited | Wholesale & retail | 2019 |
| Source Supply Chain Solutions Ltd | Professional & scientific | 2013 |
| Sourcing Xpert Ltd | Information & communication | 2025 |
| South Coast Catering Limited | Manufacturing | 1991 |
| Southbrook Accountants Limited | Professional & scientific | 2010 |
| Southbrook Business Solutions Limited | Professional & scientific | 2015 |
| Southbrook Investments Ltd | Real estate | 2019 |
| Southern Office Solutions Ltd | Wholesale & retail | 2021 |
| Southern Wales Storage Ltd | Transport & logistics | 2022 |
| Southfield Lane Stores Ltd | Wholesale & retail | 2015 |
| Southgate Corporation Limited | Financial services | 2026 |
| Southgate Group Limited | Financial services | 2025 |
| Southgate Lighting Cyprus 2 Limited | Real estate | 2026 |
| Southgate Lighting Cyprus Limited | Real estate | 2025 |
| Southgate Lighting Spain Limited | Real estate | 2025 |
| Southorn Whiterock Limited | Construction | 2014 |
| Sova Healthcare (Birmingham) Limited | Health & social care | 2015 |
| Sova Healthcare (Hounslow) Ltd | Health & social care | 2015 |
| Sova Healthcare Franchises Limited | Professional & scientific | 2021 |
| Sova Healthcare Ltd | Health & social care | 2011 |
| Sova Money Limited | Financial services | 2026 |
| Sovereign Healthcare Solutions Ltd | Administrative & support | 2025 |
| Sovereign Housing Support Ltd | Health & social care | 2023 |
| Sovereign Masonry Limited | Construction | 2020 |
| Sovereign Securities Limited | Real estate | 2013 |
| Sovereignty Solutions Limited | Information & communication | 2014 |
| Sowing Seeds Alternative Learning Limited | Education | 2024 |
| Sowing Seeds Tuition Limited | Education | 2023 |
| Sowing Seeds Wellbeing CIC | Education | 2023 |
| SP & SP Ltd | Financial services | 2025 |
| SP Batley Ltd | Wholesale & retail | 2025 |
| SP Bradford Limited | Hospitality | 2026 |
| SP Commercial Services Ltd | Wholesale & retail | 2024 |
| SP Davies Physiotherapy Limited | Health & social care | 2014 |
| SP Events Yorkshire Ltd | Hospitality | 2025 |
| SP Huddersfield Ltd | Wholesale & retail | 2025 |
| SP Leeds Ltd | Wholesale & retail | 2025 |
| SP Maintenance Ltd | Construction | 2016 |
| SP Motor Cars Limited | Wholesale & retail | 2017 |
| SP Optics Limited | Health & social care | 2017 |
| SP Revive Ltd | Arts & recreation | 2026 |
| Sp.Industries Limited | Wholesale & retail | 2020 |
| Sp.Md Group Ltd | Administrative & support | 2025 |
| Space Dreamss Ltd | Other services | 2018 |
| Space Innovative Limited | Manufacturing | 2026 |
| Spall Limited | Manufacturing | 2023 |
| Sparb Ltd | Information & communication | 2023 |
| Sparepro Ltd | Wholesale & retail | 2024 |
| Spark Housing Ltd | Households | 2021 |
| Sparked OUT Electrical Contactors Ltd | Construction | 2022 |
| Sparkle Hand Car Wash Bradford Limited | Administrative & support | 2025 |
| Sparktec Electricians Limited | Construction | 2025 |
| Sparkverseai Ltd | Information & communication | 2024 |
| Sparkyman Ltd | Construction | 2016 |
| Sparkys Salvage Ltd | Wholesale & retail | 2022 |
| Sparrowhawk Pharma Limited | Health & social care | 2022 |