| Stitching Studio Ltd | Professional & scientific | 2025 |
| Stitchit Euroafrik Ltd | Manufacturing | 2026 |
| Stitchsupply Ltd | Wholesale & retail | 2025 |
| STM Agency Limited | Professional & scientific | 2003 |
| STM Spark Limited | Information & communication | 2025 |
| Stmgrp Limited | Financial services | 2022 |
| Stobira Limited | Manufacturing | 2013 |
| Stocker Design Limited | Professional & scientific | 2024 |
| Stockk Limited | Wholesale & retail | 2022 |
| Stocklings Ltd | Information & communication | 2022 |
| Stockly Ltd | Wholesale & retail | 2025 |
| Stocknex Ltd | Wholesale & retail | 2025 |
| Stockport Car Supermarket Ltd | Wholesale & retail | 2016 |
| Stockwell Properties Ltd | Real estate | 2016 |
| Stockwell Property Holdings Limited | Real estate | 2025 |
| Stoke-On-Trent Youth Zone | Education | 2016 |
| Stokes Management Ltd | Hospitality | 2025 |
| Stokley Electronics Services Limited | Professional & scientific | 2024 |
| Stone Circle Media Ltd | Professional & scientific | 2019 |
| Stone Strength and Conditioning Ltd | Education | 2024 |
| Stonebridge Accountants & Business Advisors Limited | Extraterritorial | 2018 |
| Stonebridge Asset Management Limited | Real estate | 2018 |
| Stonebridge Bond Delegates Limited | Professional & scientific | 2023 |
| Stonebrook Property Group Ltd | Real estate | 2025 |
| Stonebyte Ltd | Energy | 2025 |
| Stonecross Homes Limited | Construction | 2019 |
| Stonefountain Ltd | Wholesale & retail | 2019 |
| Stonegate Motor Company Ltd. | Wholesale & retail | 2024 |
| Stonehill Healthcare and Education Ltd | Professional & scientific | 2025 |
| Stonehyrst Ltd | Wholesale & retail | 2021 |
| Stonemead Limited | Financial services | 2024 |
| Stonewall Prints Ltd | Wholesale & retail | 2022 |
| Stonewood Impex Ltd | Construction | 2020 |
| Stoneworks Home Ltd | Real estate | 2022 |
| Stop & Shop Local Limited | Wholesale & retail | 2025 |
| Stop My Debts Ltd | Financial services | 2025 |
| Stopford Surgical Ltd | Health & social care | 2012 |
| Stoptap N Switch Ltd | Wholesale & retail | 2012 |
| Store 24 Seven Northwest Ltd | Transport & logistics | 2013 |
| Store Box Midco Limited | Financial services | 2024 |
| Store Box Propco Limited | Real estate | 2025 |
| Store Box Self Storage Limited | Transport & logistics | 2009 |
| STORE24SEVEN Ltd | Administrative & support | 2011 |
| Storebox Self Storage (Trafford) Ltd. | Transport & logistics | 2013 |
| Storemybox Ltd | Transport & logistics | 2025 |
| Stories Like Ours Ltd | Information & communication | 2026 |
| Stork Tavern Limited | Hospitality | 2022 |
| Storm International Limited | Wholesale & retail | 1996 |
| Storm International Trustee Limited | Financial services | 2025 |
| Storm Software Solutions Limited | Information & communication | 2010 |
| Stormchain Global Response Limited | Professional & scientific | 2023 |
| Stormproofings Limited | Manufacturing | 1994 |
| Story Surge Films Ltd | Professional & scientific | 2023 |
| Storyoak Ltd | Manufacturing | 2022 |
| Stott and Smith Limited | Manufacturing | 2000 |
| Stout Crafted Ltd | Wholesale & retail | 2018 |
| Straight Back Investments Limited | Financial services | 2021 |
| Straight CUT Joinery Limited | Construction | 2024 |
| Straightforward Accountants Ltd | Professional & scientific | 2018 |
| Strandkorb Garden UK Ltd | Wholesale & retail | 2021 |
| Strange Consultancy Limited | Information & communication | 2025 |
| Strangerdnb Ltd | Information & communication | 2025 |
| Strangeways Here WE Come Ltd | Information & communication | 2012 |
| Strategic Asset Finance Limited | Financial services | 2018 |
| Strategic Digital Marketing Group Ltd | Administrative & support | 2022 |
| Strategic Golf Partnership Limited | Extraterritorial | 2007 |
| Strategic Project Services Limited | Professional & scientific | 2026 |
| Strategy & Impact Ltd | Professional & scientific | 2023 |
| Stratford Market Properties Limited | Financial services | 2019 |
| Stratford Tiling Ltd | Construction | 2017 |
| Stratia Limited | Professional & scientific | 2006 |
| Stratton KB Ltd | Construction | 2024 |
| Stravit Investments Limited | Real estate | 2016 |
| Strawberry Financial Limited | Financial services | 2003 |
| Strawbury Duck Limited | Hospitality | 2017 |
| Straxtek Ltd | Professional & scientific | 2020 |
| Stream for ALL Ltd | Professional & scientific | 2022 |
| Streamdog Productions Ltd | Information & communication | 2024 |
| Streamline Printing Limited | Manufacturing | 2013 |
| Streats MCR Ltd | Hospitality | 2024 |
| Street Haven Ltd | Wholesale & retail | 2025 |
| Street Icon Studio Ltd | Manufacturing | 2025 |
| Street Photography Limited | Professional & scientific | 2016 |
| Street Soccer Academy | Education | 2010 |
| Streeter Consulting Limited | Professional & scientific | 2016 |
| Streetwise Media Limited | Professional & scientific | 2009 |
| Strenf Fitness Company Ltd | Arts & recreation | 2020 |
| Strengthening Families Limited | Health & social care | 2022 |
| Stress Associates Limited | Professional & scientific | 2016 |
| Stretford END Investments (UK) Limited | Financial services | 2018 |
| Stretford Studios Limited | Manufacturing | 1964 |
| Strevo Ltd | Information & communication | 2026 |
| Strickland Engineering Limited | Professional & scientific | 2023 |
| Strictly Glam Boutique Ltd | Other services | 2025 |
| Strictly Tanning & Beauty Ltd | Other services | 2020 |
| Stride Holdings NW Ltd | Financial services | 2024 |
| Strides Horse Leasing Ltd | Agriculture & fishing | 2025 |
| Strikerz Football Academy Limited | Arts & recreation | 2009 |
| Strim & Trim Gardening & Landscaping Ltd | Administrative & support | 2025 |
| Striped Codex Limited | Administrative & support | 2017 |