| Southworth Commercial Vehicles Ltd | Wholesale & retail | 2018 |
| Sovereign Heights Group Ltd | Wholesale & retail | 2025 |
| Sovereign Management & Consulting Limited | Professional & scientific | 2026 |
| Sovereign Plates Ltd | Wholesale & retail | 2023 |
| Sovereign Supplies Limited | Wholesale & retail | 2021 |
| SP Electrical Services Ltd | Construction | 2018 |
| SP Management Group Ltd | Extraterritorial | 2021 |
| Spa Retreat Bolton Ltd | Other services | 2021 |
| Space and Structure Limited | Professional & scientific | 2025 |
| Space Health Solution Ltd | Information & communication | 2020 |
| Space X Estates Ltd | Real estate | 2024 |
| Spacetime Education Ltd | Information & communication | 2020 |
| Spacks Trading Limited | Real estate | 2009 |
| Spades Car Sales Bolton Limited | Wholesale & retail | 2024 |
| Spamedica Ltd | Health & social care | 2008 |
| Spanian Limited | Wholesale & retail | 2023 |
| Spanish VEG and Fruits Ltd | Wholesale & retail | 2019 |
| Spanitech Ltd | Wholesale & retail | 2023 |
| Spanner Head Limited | Manufacturing | 2024 |
| Spare Driver Services Ltd | Transport & logistics | 2013 |
| Spark Distributors Ltd | Wholesale & retail | 2025 |
| Sparkarrow Ltd | Transport & logistics | 2019 |
| Sparkinusall Ltd | Construction | 2025 |
| Sparkle and Shine by Rachel Ltd | Administrative & support | 2026 |
| Sparkles Carwash (Blackburn) Ltd | Administrative & support | 2013 |
| Sparklify Ltd | Wholesale & retail | 2023 |
| SPARLINGDECO4U Ltd | Manufacturing | 2025 |
| Spashisha Ltd | Hospitality | 2024 |
| Spatial Environments Ltd | Administrative & support | 2014 |
| SPB Roofing Solutions Ltd | Construction | 2014 |
| Spbailey Group Limited | Construction | 2025 |
| Spbl Ltd | Construction | 2025 |
| SPC Coffey Services Ltd | Transport & logistics | 2025 |
| SPC13 Ltd | Information & communication | 2019 |
| SPD Express Ltd | Transport & logistics | 2021 |
| Speakify Ltd | Professional & scientific | 2024 |
| Speakman Build Ltd | Construction | 2019 |
| Speakmans Travel Ltd | Administrative & support | 2024 |
| Special Metal Alloys UK Ltd | Mining & quarrying | 2020 |
| Specialised Engineering Services Limited | Wholesale & retail | 2003 |
| Specialist Group Glossop Ltd | Construction | 2016 |
| Specialist Haulage LLP | | 2015 |
| Specialist Smart Repairs Ltd | Wholesale & retail | 2022 |
| Specialist SRT Ltd | Administrative & support | 2022 |
| Specialist Wind Services Limited | Administrative & support | 2024 |
| Specifeyes Group Ltd | Professional & scientific | 2019 |
| Specific Components (Bolton) Limited | Extraterritorial | 2012 |
| Spectacles Shop Limited | Wholesale & retail | 2022 |
| Spectra Eco Ltd | Construction | 2023 |
| Spectra Plant Limited | Administrative & support | 2023 |
| Spectra Security Limited | Administrative & support | 1990 |
| Spectre Live Events Ltd | Information & communication | 2018 |
| Spectrum (NW) Ltd | Construction | 2010 |
| Spectrum Products Limited | Wholesale & retail | 2004 |
| Speed Master Logistics Limited | Transport & logistics | 2020 |
| Speed Trade Ltd | Hospitality | 2025 |
| Speedhouse Ltd | Wholesale & retail | 2022 |
| Speedier Scaffolding Limited | Construction | 1982 |
| Speedwell Couriers Limited | Transport & logistics | 2025 |
| Speedwell Ecology Ltd | Agriculture & fishing | 2025 |
| Speedy Hooks Ltd | Transport & logistics | 2024 |
| Speedy Scaffolding Limited | Construction | 2018 |
| Speke Retail Limited | Construction | 2026 |
| Spencer Churchill Law Ltd | Professional & scientific | 2018 |
| Spendify Ltd | Wholesale & retail | 2023 |
| Spennymoor Care Home Limited | Health & social care | 2005 |
| Spenz Cleaning Services Limited | Administrative & support | 2022 |
| Spenz Ltd | Health & social care | 2024 |
| Spenzax Cleaning Services Ltd | Administrative & support | 2021 |
| Spenzaxlove Kitchen & Event Organising Ltd | Hospitality | 2024 |
| SPF Mortgages Limited | Financial services | 2021 |
| SPG Engineering Services Ltd | Professional & scientific | 2023 |
| SPG Pointing Limited | Construction | 2026 |
| SPG Relocations Ltd | Administrative & support | 2025 |
| SPH Electrical Services (NW) Limited | Construction | 2013 |
| Sphere Care Solutions Ltd | Health & social care | 2021 |
| Sphinx Property Group Limited | Real estate | 2023 |
| SPI Appleton Limited | Extraterritorial | 2017 |
| SPI Courier Ltd | Transport & logistics | 2026 |
| SPI Mcgrattan Piling Limited | Extraterritorial | 2008 |
| Spic and Span Northwest Ltd | Administrative & support | 2017 |
| Spice House NW Ltd | Hospitality | 2025 |
| Spice Hutt Ltd | Real estate | 2025 |
| Spice Valley Bar & Restaurant Ltd | Hospitality | 2018 |
| Spice Valley Catering Ltd | Hospitality | 2018 |
| Spice Valley Events Ltd | Hospitality | 2024 |
| Spiced Pear Limited | Health & social care | 2020 |
| Spicewing Ltd | Hospitality | 2020 |
| Spicy Heaven Ltd | Hospitality | 2024 |
| Spiderweb Network Solutions Limited | Information & communication | 2019 |
| Spikes Recovery Services Limited | Transport & logistics | 2022 |
| Spiralcrest Limited | Transport & logistics | 1983 |
| Spiritworks Ltd | Wholesale & retail | 2016 |
| Spirometrix Ltd | Health & social care | 2024 |
| Splash Stars Swim School Ltd | Arts & recreation | 2016 |
| Splendore Limited | Other services | 2008 |
| Splish Splash North West Limited | Arts & recreation | 2016 |
| Splitsec Technologies Limited | Other services | 2023 |
| Splyntor Labs Limited | Information & communication | 2024 |
| Spmcjm PUB Company Ltd | Hospitality | 2017 |