| Sofia Bolton Ltd | Hospitality | 2023 |
| Soft Aesthetics Limited | Health & social care | 2025 |
| Soft Ember Limited | Wholesale & retail | 2026 |
| Soft Play Co Northwest Ltd | Administrative & support | 2024 |
| Sogeke Limited | Information & communication | 2026 |
| Sogrecroft Ltd | Real estate | 2023 |
| Soha International Trading Ltd | Wholesale & retail | 2024 |
| Sohail Hakim Ltd | Health & social care | 2008 |
| Sohan Tech Ltd | Wholesale & retail | 2023 |
| Sohob Limited | Information & communication | 2024 |
| Soka Limited | Hospitality | 2021 |
| Sokomimi Care Limited | Health & social care | 2023 |
| SOL Blinds (Trade Sales) Limited | Wholesale & retail | 1996 |
| SOL Elite Investment Services Ltd | Real estate | 2014 |
| SOL Online Ltd | Wholesale & retail | 2024 |
| Solace Hair Ltd | Other services | 2025 |
| Solar Clinic Ltd | Construction | 2024 |
| Solar Coaching Limited | Education | 2024 |
| Solarno Ltd | Information & communication | 2024 |
| Solaymantash Associates Limited | Real estate | 1989 |
| Solc Limited | Administrative & support | 2022 |
| Solco Pyroelec UK Ltd | Wholesale & retail | 2014 |
| Soldiers of Core Entertainment Ltd | Arts & recreation | 2018 |
| Sole Shopper UK Ltd | Wholesale & retail | 2020 |
| Soledtothehighestbidder Ltd | Wholesale & retail | 2019 |
| Solid Wall Solutions Limited | Administrative & support | 2010 |
| Solid-State Engineering Ltd | Other services | 2016 |
| Solidbrick Property Group Ltd | Construction | 2026 |
| Solidframe Scaffolding Ltd | Construction | 2026 |
| Solihull Stores Ltd | Wholesale & retail | 2017 |
| Solis Vale Ltd | Manufacturing | 2026 |
| Solma Intelligence Ltd | Professional & scientific | 2025 |
| Solnika Ltd | Real estate | 2017 |
| Solo Motor Group Ltd | Wholesale & retail | 2023 |
| Solomon Travel Ltd | Transport & logistics | 2022 |
| Solomon Travel Solutions Ltd | Transport & logistics | 2015 |
| Solon Legal Services Ltd | Professional & scientific | 2016 |
| Solstice Global Limited | Professional & scientific | 2023 |
| Solus Management Limited | Information & communication | 2019 |
| Solution Consultant Ltd | Information & communication | 2018 |
| Solutions Delivered Limited | Professional & scientific | 2019 |
| Solutions in Procurement Ltd | Professional & scientific | 2015 |
| Solutions Property Holdings Ltd | Real estate | 2020 |
| Solutions Property Renovations Ltd | Construction | 2011 |
| Sombol Safety Ltd | Wholesale & retail | 2017 |
| Someet Technology Limited | Information & communication | 2024 |
| Something Random Gifts and Designs Ltd | Wholesale & retail | 2025 |
| Somnium Ventures Limited | Real estate | 2021 |
| Somtam Street Limited | Wholesale & retail | 2016 |
| Sona James Health Care Limited | Health & social care | 2016 |
| Sonabeds Ltd | Manufacturing | 2025 |
| Songwood Ltd | Real estate | 2021 |
| Soni Group UK Ltd | Wholesale & retail | 2020 |
| Sonia Recruiting Limited | Health & social care | 2012 |
| Soniic Broadcast Limited | Information & communication | 2026 |
| Sonik Consulting Ltd | Information & communication | 2026 |
| Sonika Ghaie Limited | Real estate | 2012 |
| Soon London Limited | Other services | 2013 |
| Sooshi Store Ltd | Professional & scientific | 2025 |
| Sopharm Ltd | Health & social care | 2023 |
| Sopharmuk Ltd | Health & social care | 2026 |
| Sopron Mini Market Ltd | Wholesale & retail | 2018 |
| SOR & Co Ltd | Information & communication | 2014 |
| Sora Tech Logistics Ltd | Water & waste | 2025 |
| Sorby Carpentry Ltd | Manufacturing | 2025 |
| Sorianoto Ltd | Health & social care | 2022 |
| Sorpen Financial Solutions Limited | Financial services | 2004 |
| Sorploh's Properties Limited | Real estate | 2020 |
| Sorplohs-Industries Ltd | Construction | 2021 |
| Sorted TV Ltd | Information & communication | 2000 |
| SOS Hygiene Technologies Ltd | Other services | 2012 |
| Soslick Systems Limited | Information & communication | 2017 |
| Soul Serenity Limited | Manufacturing | 2025 |
| Soulrish Limited | Health & social care | 2025 |
| Soumah Total Wellbeing Ltd | Transport & logistics | 2018 |
| Soumba ST Business Ltd | Administrative & support | 2023 |
| Soumo Digital Limited | Information & communication | 2011 |
| Sound Reduction Systems Ltd. | Manufacturing | 1981 |
| Souqify Ltd | Wholesale & retail | 2024 |
| Sour M4SH Limited | Wholesale & retail | 2022 |
| Sourc 24-7 Limited | Professional & scientific | 2025 |
| Source & Spend Ltd | Wholesale & retail | 2023 |
| Source Aligned Income Limited | Professional & scientific | 2025 |
| South Coast Clearance Services Ltd | Water & waste | 2023 |
| South Glow Ltd | Manufacturing | 2022 |
| South Pier Food Limited | Hospitality | 2022 |
| South Ribble Dyslexia Ltd | Education | 2025 |
| South West Lightning Protection Ltd | Construction | 2026 |
| Southcoast Biltong Ltd | Wholesale & retail | 2025 |
| Southern Prime Cleaning Services Ltd | Administrative & support | 2025 |
| Southern Smart Energy Holdings Ltd | Financial services | 2023 |
| Southern Smart Energy Ltd | Construction | 2023 |
| Southern Smart Properties Ltd | Real estate | 2024 |
| Southerns Broadstock Interiors Limited | Professional & scientific | 2025 |
| Southfork-Iroko Consulting Limited | Information & communication | 2022 |
| Southlands Residential Home Limited | Health & social care | 1987 |
| Southlands Ventures Ltd | Administrative & support | 2020 |
| Southleigh Properties Ltd | Real estate | 2019 |
| Southport Roller Shutters Ltd | Manufacturing | 2010 |
| Southwood Properties (N W) Ltd | Construction | 2014 |