| Scho & Co Ltd | Other services | 2013 |
| Schofields Limited | Financial services | 1984 |
| School Analytics Ltd | Education | 2012 |
| School Necessities Ltd | Administrative & support | 2021 |
| Schoolgpt Limited | Information & communication | 2024 |
| Schools Commercial Gallery (UK) Limited | Professional & scientific | 2004 |
| SCI Imran Arfan Ltd | Real estate | 2025 |
| Sciama Family Trustees Limited | Professional & scientific | 1966 |
| Scientes Limited | Extraterritorial | 2003 |
| Scigala Enterprises Limited | Other services | 2026 |
| Scintra Limited | Professional & scientific | 1996 |
| Scitas Ltd | Information & communication | 2026 |
| Scitype Writing Ltd | Other services | 2023 |
| SCJ Software Limited | Information & communication | 2021 |
| Scnted Ltd | Manufacturing | 2018 |
| Scope International (UK) Limited | Professional & scientific | 2013 |
| Scope Technology Ltd | Wholesale & retail | 2023 |
| Score Draw Limited | Wholesale & retail | 2002 |
| Scorpio Developments Limited | Professional & scientific | 2003 |
| Scorpion Automotive Limited | Manufacturing | 2009 |
| Scorpion Compressed Air Limited | Manufacturing | 2005 |
| Scorpion Group Holdings Limited | Manufacturing | 2023 |
| Scorpion Track Ltd | Administrative & support | 2018 |
| Scorpious Limited | Real estate | 2016 |
| Scotco (Northern) Limited | Hospitality | 2014 |
| Scotco Central Limited | Administrative & support | 2016 |
| Scotco Midlands Limited | Hospitality | 2007 |
| Scotco NI Limited | Hospitality | 2016 |
| Scotco One Five Five Limited | Hospitality | 2017 |
| Scotco One Four Five Limited | Hospitality | 1968 |
| Scotco Restaurants Limited | Hospitality | 1995 |
| Scotco Restaurants Southern Limited | Hospitality | 2002 |
| Scott Advisory Ltd | Professional & scientific | 2025 |
| Scott Colorectal Limited | Health & social care | 2010 |
| Scott Fraser Consulting Ltd | Information & communication | 2020 |
| Scott Mcqueen Ltd | Construction | 2010 |
| Scott Rowland Construction Limited | Construction | 2013 |
| Scouted London Ltd | Administrative & support | 2021 |
| Scowcroft Properties Ltd | Real estate | 2020 |
| SCP Investments Limited | Real estate | 1997 |
| SCP Yorkshire Limited | Real estate | 2026 |
| Scpi Bowland Ltd | Real estate | 2007 |
| Scpi Consulting Ltd | Real estate | 2007 |
| SCR Impact Limited | Education | 2005 |
| Scraps and Spares Ltd | Wholesale & retail | 2025 |
| Screedmasters Ltd | Construction | 2012 |
| Screenplay Films Limited | Information & communication | 2016 |
| Scruffymonkey Digital Media Ltd. | Information & communication | 2013 |
| Scruffyworks Coaching Ltd | Professional & scientific | 2023 |
| Scsc Holdings Ltd | Wholesale & retail | 2020 |
| Scuderia Automobilia Ltd | Wholesale & retail | 2026 |
| Sculpt Club Ltd | Arts & recreation | 2026 |
| Sculptedbydoctors Ltd | Health & social care | 2019 |
| Sculptedbydrruqayyah Limited | Health & social care | 2025 |
| SD Bars Ltd | Wholesale & retail | 2015 |
| SD Cheshire Oaks Limited | Construction | 2021 |
| SD Creations Limited | Information & communication | 2025 |
| SD Elite Holdings Ltd | Construction | 2021 |
| SD Hawksmoor Limited | Construction | 2022 |
| SD Hooton Limited | Construction | 2020 |
| SD Local Limited | Wholesale & retail | 2026 |
| SD NW Ltd | Hospitality | 2025 |
| SD Prime Point Limited | Construction | 2017 |
| SDA Traders UK Ltd | Wholesale & retail | 2024 |
| SDC Marine Services Ltd. | Agriculture & fishing | 2014 |
| SDF Energy Ltd | Construction | 2025 |
| SDG Driving Limited | Transport & logistics | 2020 |
| SDH Building Services Ltd | Construction | 2005 |
| SDI Collective Capital Ltd | Construction | 2025 |
| SDI Living Ltd | Hospitality | 2025 |
| SDK Medical Limited | Health & social care | 2014 |
| SDK Property Group Limited | Real estate | 2026 |
| Sdmi Fashion Ltd | Wholesale & retail | 2025 |
| SDP Homes Ltd | Construction | 2024 |
| Sdpeet Ltd | Real estate | 2022 |
| SDR Automotive Ltd | Wholesale & retail | 2025 |
| SDR365 Limited | Administrative & support | 2025 |
| SDS Aerospace Limited | Other services | 2008 |
| SDT Corporate Ltd | Wholesale & retail | 2022 |
| SDT Design Services Limited | Professional & scientific | 2014 |
| SDZ Properties Ltd | Real estate | 2020 |
| SE Design & Builders Limited | Construction | 2019 |
| Sea Dream Properties Ltd | Real estate | 2021 |
| Sea Pinks Consulting Limited | Professional & scientific | 2021 |
| Seafront Leisure Ltd | Hospitality | 2015 |
| Seafront Simulations Ltd | Information & communication | 2020 |
| Seahawk Bidco Limited | Professional & scientific | 2018 |
| Seaicare Ltd | Education | 2025 |
| Sean Impey Horsepower Limited | Transport & logistics | 2019 |
| Sean J Whelan Limited | Hospitality | 2020 |
| Sean Owen Golf Limited | Arts & recreation | 2011 |
| Searchelectoralroll Limited | Administrative & support | 2015 |
| Seas the Day Fitties Ltd | Real estate | 2020 |
| Seasons PVT Ltd | Wholesale & retail | 2014 |
| Seaton Essential Limited | Wholesale & retail | 2025 |
| Seattle Midco Limited | Professional & scientific | 2016 |
| Seattle Topco Limited | Professional & scientific | 2016 |
| Seaview Logistics Ltd | Transport & logistics | 2025 |
| Seberin Ltd | Extraterritorial | 2024 |
| Sebs Properties Ltd | Real estate | 2021 |