| Piob Mhor of Scotland Ltd. | Wholesale & retail | 2001 |
| Pitkethly-Bate Ltd | Wholesale & retail | 2025 |
| PJ PAN Limited | Wholesale & retail | 2017 |
| PK Basilica Ltd | Construction | 2025 |
| PK Safety and Training Services Ltd | Transport & logistics | 1995 |
| Play Academy (Scotland) Ltd | Health & social care | 2025 |
| Plunkgroup Ltd | Arts & recreation | 2021 |
| Pondfauld Holidays Limited | Hospitality | 2003 |
| Praetor Defence Limited | Wholesale & retail | 2025 |
| Precision Data Solutions Ltd | Professional & scientific | 2019 |
| Premier Environmental Services Limited | Professional & scientific | 2019 |
| Premier Homes Scotland Ltd | Construction | 2019 |
| Present Focus CIC | Professional & scientific | 2024 |
| Promethius Developments Limited | Extraterritorial | 2001 |
| Pyro Pizza Ltd | Hospitality | 2019 |
| Qwerty 101 Ltd | Construction | 2015 |
| R B R Tanner Limited | Agriculture & fishing | 2016 |
| R C Electrical (Perthshire) Ltd | Construction | 2022 |
| R Smith Joiner and Contractor Ltd | Construction | 2018 |
| Rabstone-Stonemasons Limited | Construction | 2025 |
| Rachan Ltd | Professional & scientific | 2022 |
| Radar Medical Writing Ltd | Professional & scientific | 2010 |
| Rainbow Training Ltd | Information & communication | 2024 |
| Raphael Francis Ltd | Information & communication | 2021 |
| RAY Minds Consulting UK Ltd | Information & communication | 2025 |
| Rdfencing Ltd. | Construction | 2017 |
| RDO Joinery Ltd | Construction | 2025 |
| Redfox Hospitality Limited | Hospitality | 2020 |
| Reform Food Scot Ltd | Hospitality | 2025 |
| Reform Foods Ltd | Hospitality | 2026 |
| Regeneration Station Hobbies Ltd | Wholesale & retail | 2025 |
| Restore and Evolve Limited | Health & social care | 2024 |
| Rhythmic Tide Records Ltd | Information & communication | 2025 |
| River Lodge Consulting Limited | Professional & scientific | 2018 |
| RJM Leisure Limited | Hospitality | 2019 |
| Rjrb Property Ltd | Real estate | 2023 |
| RLR Contracts Ltd | Construction | 2018 |
| RLR Drainage Limited | Construction | 2023 |
| Robbie Winton Ltd | Administrative & support | 2025 |
| Robert Morris & SON Limited | Agriculture & fishing | 1924 |
| Robert Smith Contractors Limited | Construction | 2002 |
| Robertson and Mcrae Painting and Decorating Ltd | Construction | 2017 |
| Rochallie Farm | | 1984 |
| Rococo Ltd | Administrative & support | 2016 |
| Rodney Neil Financial Services (Blairgowrie) Limited | Financial services | 2000 |
| Roinca Limited | Financial services | 2022 |
| Ronnie Brown Plumbing Ltd | Construction | 2026 |
| Roost Cabins Ltd | Hospitality | 2022 |
| Roving VET Ltd | Professional & scientific | 2018 |
| RSA Blairgowrie Ltd | Agriculture & fishing | 2024 |
| RSW Design Ltd | Administrative & support | 2022 |
| Rygd Ltd | Professional & scientific | 2017 |
| Ryse Digital Ltd | Information & communication | 2020 |
| S Weir Electrical Ltd | Construction | 2024 |
| Sablp Limited | Health & social care | 2023 |
| Saint Roque's Automobile Company, Limited | Wholesale & retail | 1921 |
| Sampan Blairgowrie Limited | Hospitality | 2019 |
| Sams Rental Properties Ltd | Real estate | 2024 |
| Sandvollan Limited | Professional & scientific | 2021 |
| Sara Spackman & Simon Spackman LP | | 2021 |
| Sarkar (DEV) Limited | Construction | 2002 |
| SAW Partners Ltd | Wholesale & retail | 2026 |
| SC Stan Property Ltd | Real estate | 2025 |
| Scot Food Ltd | Hospitality | 2025 |
| Scot-Lad Limited | Manufacturing | 1996 |
| Scotia Design & Install Ltd | Construction | 2026 |
| Scott-Heat Ltd | Construction | 2023 |
| Scottish Highlands & Islands Rock Limited | Arts & recreation | 2006 |
| Seacare Compass Blairgowrie Limited | Hospitality | 2025 |
| Shaw Lets Limited | Hospitality | 2024 |
| Shazz Mclazz Ltd | Wholesale & retail | 2021 |
| Sholach Trees Limited | Agriculture & fishing | 2016 |
| Sign Industries Limited | Manufacturing | 2017 |
| Simple Approach Estate Agents Ltd | Real estate | 2016 |
| Simple Approach Estate and Letting Agents Dundee Ltd | Real estate | 2019 |
| Simple Approach Mortgages Perth & Dundee Ltd | Financial services | 2021 |
| Sisserou Medical Education Consultancy Ltd | Professional & scientific | 2026 |
| SJB BIN Cleaning Limited | Administrative & support | 2023 |
| SJB Cleaning Services Ltd | Administrative & support | 2020 |
| SKI Slope Services Limited | Manufacturing | 1985 |
| Skin Bandits Ltd | Health & social care | 2017 |
| Skin Clinic Alyth Ltd | Other services | 2025 |
| Sliderz Ltd | Hospitality | 2023 |
| Slipstream Identity Services Ltd | Information & communication | 2024 |
| Smith Taylor & Glen Limited | Construction | 2013 |
| Snuzikgrze Ltd | Transport & logistics | 2026 |
| Soilzarie Ltd | Hospitality | 2024 |
| Solais Design Ltd | Wholesale & retail | 2024 |
| Solais Wellness Limited | Health & social care | 2025 |
| Sophie Brown Consulting Limited | Professional & scientific | 2026 |
| Sorbus Geophysical Ltd | Professional & scientific | 2016 |
| Southlaird Limited | Professional & scientific | 2001 |
| Spfo Group Ltd | Construction | 2020 |
| Spfo Ltd | Manufacturing | 2020 |
| Spfo Property Ltd | Manufacturing | 2025 |
| Sports Facility and Construction Management Limited | Construction | 2021 |
| SSA Partners Ltd | Wholesale & retail | 2024 |
| Sstormrite Roofing and Joinery Limited | Construction | 2026 |
| ST Ninians Home Care Ltd | Health & social care | 2013 |
| Stability Scotland Limited | Education | 2015 |