| Smiths Equipment Hire Limited | Construction | 1970 |
| Smiths Topco Limited | Financial services | 2025 |
| SMJ Joinery Contractors Ltd | Construction | 2021 |
| Smoo Productions Ltd | Information & communication | 2016 |
| Smoogro Services Limited | Other services | 2018 |
| Smooth Breeze Charters Limited | Arts & recreation | 2026 |
| SMP Blackpool Properties Limited | Real estate | 2026 |
| Snacksurprise Limited | Wholesale & retail | 2020 |
| Snap (Blackpool) Ltd | Education | 2012 |
| Snap Payroll Ltd | Information & communication | 2019 |
| Snapper Design & Print Limited | Manufacturing | 2024 |
| Snarl Ltd | Professional & scientific | 2025 |
| Snee Roofing & Maintenance Ltd | Construction | 2022 |
| Sniffly Dogs Ltd | Information & communication | 2024 |
| SO Painting and Decorating Ltd. | Construction | 2012 |
| SOA Engineering Ltd | Professional & scientific | 2012 |
| SOA Safety Limited | Professional & scientific | 2012 |
| Soakstudio Ltd | Wholesale & retail | 2021 |
| Socal Healthcare Ltd | Health & social care | 2012 |
| Social Active Limited | Extraterritorial | 2019 |
| Social Enterprise Solutions (UK) C.I.C | Professional & scientific | 2006 |
| Social Gains Limited | Information & communication | 2016 |
| Social Prosper Ltd | Wholesale & retail | 2025 |
| Socialflow Ltd | Professional & scientific | 2024 |
| Sofia Property Investments Ltd | Real estate | 2021 |
| Sofiabygrace UK Ltd | Wholesale & retail | 2024 |
| Soft Pedal Investments Limited | Information & communication | 2007 |
| Soft Petals PVT Ltd | Wholesale & retail | 2025 |
| Soft TIP UK Limited | Administrative & support | 2018 |
| Soft Tissue Therapies Ltd | Health & social care | 2021 |
| Softamize Limited | Wholesale & retail | 2024 |
| Software Division Limited | Information & communication | 1988 |
| Sojourni Ltd | Hospitality | 2023 |
| Sokapase Ltd | Health & social care | 2025 |
| Solar GEN Plus Limited | Energy | 2011 |
| Solar Innovations Solutions Ltd | Construction | 2023 |
| Solaris One Limited | Professional & scientific | 2018 |
| Solea Yachting Ltd | Extraterritorial | 2023 |
| Solo Food Ltd | Hospitality | 2022 |
| Solo Moda Limited | Wholesale & retail | 2003 |
| Solos Advisory Ltd | Professional & scientific | 2025 |
| Somerset Court RTM Company Limited | Households | 2018 |
| Somerside Photography Limited | Professional & scientific | 2011 |
| Something Sweet Limited | Wholesale & retail | 2023 |
| Sommmh Ltd | Wholesale & retail | 2025 |
| Songbird Properties Ltd | Real estate | 2024 |
| Sonic Seasider Ltd | Hospitality | 2025 |
| Sonje Jones Design Team Ltd | Other services | 2017 |
| Sonus Investments Ltd | Construction | 2025 |
| Soozys People Limited | Administrative & support | 2019 |
| Sophie Richaume Limited | Information & communication | 2016 |
| Sorley Accountants Ltd | Professional & scientific | 2024 |
| Sorority House Ltd | Other services | 2021 |
| Sotto Pizzeria Limited | Hospitality | 2018 |
| Sotur Yachting Ltd | Extraterritorial | 2025 |
| Soul Creations Ltd | Wholesale & retail | 2021 |
| Soul Holistic Healing Limited | Health & social care | 2016 |
| Sound Lighting Ltd | Arts & recreation | 2013 |
| Sound Stage Lighting Live Ltd | Other services | 2017 |
| Soundwave Blackpool Ltd | Hospitality | 2025 |
| Sourcing & Procurement Limited | Wholesale & retail | 2019 |
| South Beach Construction Company Ltd | Real estate | 2009 |
| South Beach Devs Ltd | Information & communication | 2022 |
| South Beach Estates Ltd | Real estate | 2017 |
| South Beach Hotel Ltd | Hospitality | 2025 |
| South East Consultancy Services Ltd | Information & communication | 2018 |
| South Ford Consulting Limited | Professional & scientific | 2016 |
| South Lawn Resident Owners Association Limited | Households | 2002 |
| South Park Management Company Limited | Households | 2004 |
| South Shore Accountants Limited | Professional & scientific | 2013 |
| South Shore Carpets and Rugs Limited | Wholesale & retail | 2018 |
| South Shore Community Partnership Limited | Administrative & support | 2017 |
| South Shore Metal Fabrications Ltd | Manufacturing | 2009 |
| South Shore Pitstop Community Cafe CIC | Hospitality | 2025 |
| South Shore Property Ltd | Construction | 2025 |
| South South Store Ltd | Transport & logistics | 2026 |
| Southampton Cruise Centre Limited | Administrative & support | 2020 |
| Southbeach Streetfood UK Limited | Hospitality | 2019 |
| Southport & Districts Window Cleaning Ltd | Administrative & support | 2021 |
| Southport Eats Limited | Hospitality | 2020 |
| Southwood Engineering Ltd | Professional & scientific | 2012 |
| Southworth Electrical Ltd | Professional & scientific | 2012 |
| Sovereign Books Ltd. | Extraterritorial | 2005 |
| SP Management Services Ltd. | Other services | 2017 |
| SP Notaries Ltd | Professional & scientific | 2026 |
| Spa Food & Wine Ltd | Wholesale & retail | 2021 |
| Space for Purpose Community Interest Company | Information & communication | 2022 |
| Spaces Blackpool Ltd | Transport & logistics | 2025 |
| Spalbord Limited | Real estate | 2015 |
| Spank Design Limited | Information & communication | 2015 |
| Sparky Deals Limited | Wholesale & retail | 2025 |
| Spartan Coaching Limited | Education | 2024 |
| Spartan Gyros Ltd | Hospitality | 2023 |
| SPC Healthcare Ltd | Health & social care | 2024 |
| Speakman Properties Limited | Real estate | 2019 |
| Spearhead Yachting Limited | Other services | 2025 |
| Specialist GAS Assessment Services Ltd. | Administrative & support | 1998 |
| Specialist Pumps and Hydraulics Ltd | Wholesale & retail | 2026 |
| Specialist Rescue Medic Limited | Professional & scientific | 2016 |
| Specialist Sparks Installation and Consultancy Ltd | Construction | 2025 |