| Dwebs Limited | Professional & scientific | 2005 |
| Dwpm Consulting Limited | Administrative & support | 2025 |
| DWS Elec Ltd | Energy | 2017 |
| Dwyer Safety Ltd | Professional & scientific | 2025 |
| DX9 Ltd | Wholesale & retail | 2016 |
| Dxarma Limited | Extraterritorial | 2025 |
| Dyd-Ro Limited | Construction | 2015 |
| Dymott Digital Limited | Professional & scientific | 2026 |
| Dynamic Expo Ltd | Administrative & support | 2025 |
| Dynamic Innovative Consulting Ltd | Information & communication | 2019 |
| Dynamic Specialist Engineers Ltd | Professional & scientific | 2021 |
| Dynamite Performance Improvement Ltd | Professional & scientific | 2018 |
| Dynamite Projects Ltd | Real estate | 2017 |
| Dysa UK Limited | Hospitality | 2019 |
| E & H Recruitment Group Ltd | Administrative & support | 2023 |
| E C Chemical Productions Limited | Administrative & support | 1994 |
| E D C (Blackpool) Limited | Wholesale & retail | 1992 |
| E Dugdale Sons & Grandson Limited | Construction | 2014 |
| E F Nice Foods Ltd | Hospitality | 2019 |
| E G Shoes Limited | Wholesale & retail | 2016 |
| E P Wigglesworth & Sons Limited | Hospitality | 1984 |
| E Property Repairs Ltd | Construction | 2009 |
| E&M Lancashire Holdings Ltd | Hospitality | 2024 |
| E-Cap Charging Points Limited | Construction | 2020 |
| E-Cap Energy Limited | Construction | 2020 |
| E-Waste and Hard Drive Disposal Services Ltd | Water & waste | 2023 |
| E.D. Schreiber Builders Limited | Construction | 2014 |
| E.Montero Ltd | Information & communication | 2016 |
| E6 Interactive Limited | Information & communication | 2020 |
| EA House Ltd | Wholesale & retail | 2026 |
| EAF Consultancy Limited | Information & communication | 2014 |
| Eagle and Child Hospitality Ltd | Hospitality | 2020 |
| Eagle Commercial Cleaning Ltd | Administrative & support | 2020 |
| Eagle Peak Limited | Information & communication | 2019 |
| Earlam Consulting Limited | Professional & scientific | 2026 |
| Earthly Love Limited | Wholesale & retail | 2020 |
| Earthmarks Limited | Information & communication | 2013 |
| Easebrand Limited | Real estate | 1987 |
| Easi Energy Ltd | Administrative & support | 2024 |
| Easipay Merchant Services Ltd | Professional & scientific | 2023 |
| Easitalk Ltd | Information & communication | 2025 |
| Eassda Ltd | Wholesale & retail | 2025 |
| East & West Cuisine Ltd | Hospitality | 2025 |
| East Pines Friary Limited | Hospitality | 2013 |
| EAST4WEST Blackpool Limited | Hospitality | 2025 |
| Easthams Group Holdings Limited | Financial services | 2025 |
| Easthams Solicitors Limited | Public administration | 2006 |
| Eastview Holdings Limited | Real estate | 2018 |
| Eastview Leisure Limited | Hospitality | 1995 |
| Easy MGT Hotels Ltd | Hospitality | 2024 |
| Easy PAY Network Limited | Administrative & support | 2011 |
| Easy Switch Ltd | Professional & scientific | 2024 |
| Easy-Hire (Power Tools) Limited | Administrative & support | 1982 |
| Easypeasy IT Ltd | Information & communication | 2019 |
| Easyspanishrentals.Com Ltd | Real estate | 2022 |
| Easytide Paddle Co Ltd | Wholesale & retail | 2021 |
| EAT 07 Ltd | Hospitality | 2024 |
| EAT Italia Ltd | Hospitality | 2025 |
| EAT More Blackpool Limited | Hospitality | 2025 |
| EAT Sleep Entertainment Ltd | Hospitality | 2014 |
| EAT the Italian Way Ltd | Hospitality | 2025 |
| Eaton Kenilworth Russel Management Company Limited | Households | 1976 |
| Ebizzy Limited | Wholesale & retail | 2014 |
| EBP Project Management Ltd | Households | 2017 |
| EC Aqua Limited | Construction | 2023 |
| EC Ecology Limited | Wholesale & retail | 2018 |
| EC Procure Limited | Administrative & support | 2025 |
| Ecan Consulting Limited | Professional & scientific | 2015 |
| ECE Yachting Ltd | Extraterritorial | 2023 |
| Ecell Global Limited | Manufacturing | 2005 |
| Ecfibre Ltd | Manufacturing | 2023 |
| Echo Yachting Ltd | Extraterritorial | 2023 |
| Echo&Aura Ltd | Health & social care | 2025 |
| Eclipse Traffic Management Ltd. | Construction | 2015 |
| Eco 4 North West Ltd | Real estate | 2023 |
| Eco Advisory Services Limited | Professional & scientific | 2023 |
| Eco Grants Services Ltd | Professional & scientific | 2019 |
| Eco Homes Installations Ltd | Construction | 2025 |
| Eco-Manual Ltd | Administrative & support | 2021 |
| ECO4U Ltd | Professional & scientific | 2023 |
| Ecofuturesgb Ltd | Other services | 2024 |
| Ecoloft Ltd | Construction | 2025 |
| Ecopaws Collective Ltd | Wholesale & retail | 2025 |
| Ecoroof Systems Ltd | Construction | 2025 |
| Ecosse C&I Services Limited | Professional & scientific | 2023 |
| Ecostrip Ltd | Professional & scientific | 2010 |
| Ecotech Solar Solutions Ltd | Wholesale & retail | 2025 |
| Ed-It Solutions (UK) Limited | Information & communication | 2009 |
| EDC Electrical & Developments Limited | Construction | 2016 |
| Edelweiss Care Group Limited | Financial services | 2021 |
| Eden Apartments Ltd | Real estate | 2021 |
| Eden Driveways and Patios Limited | Construction | 2019 |
| Eden Grove (Bolton) Management Company Limited | Households | 2021 |
| Eden Lounge London Limited | Hospitality | 2023 |
| Edenvale Leisure Ltd | Real estate | 2019 |
| Edgify Limited | Information & communication | 2009 |
| EDJ Blackpool Ltd | Hospitality | 2019 |
| EDU Trainers Ltd | Wholesale & retail | 2025 |
| Education at Early Years Limited | Education | 2020 |
| Educational Entertainment Limited | Administrative & support | 2016 |