| DSM Financial Services Limited | Financial services | 2016 |
| DSR Logistics Ltd | Wholesale & retail | 2025 |
| DST Media Ltd | Professional & scientific | 2024 |
| DSY Medical Limited | Health & social care | 2014 |
| DT Capital Ltd | Real estate | 2025 |
| DTC Collective Ltd | Wholesale & retail | 2023 |
| DTI Collective Limited | Other services | 2025 |
| DTI Commercial Holdings Limited | Real estate | 2025 |
| DTI Property Ltd | Real estate | 2023 |
| DTM Groundworks Limited | Construction | 2012 |
| DTS Recovery + Transport Limited | Transport & logistics | 2023 |
| DUA ALI Ltd | Administrative & support | 2025 |
| DUA Food Services Ltd | Hospitality | 2023 |
| Dubai Chocolate Bar Ltd | Manufacturing | 2024 |
| Duckworth Hall Properties Ltd | Extraterritorial | 2021 |
| Dudley Hill Site Ltd | Real estate | 2020 |
| Dudley Road Limited | Information & communication | 2015 |
| Dudley Road Publishing Limited | Information & communication | 2015 |
| Duffin's Estate Agents Ltd | Real estate | 2011 |
| Duffin's Sales Ltd | Real estate | 2022 |
| Duffins Investments Ltd | Other services | 2017 |
| Dunecht Whisky Ltd | Wholesale & retail | 2020 |
| Dunkel Ltd | Hospitality | 2015 |
| Dunlop Management Solutions Ltd | Professional & scientific | 2024 |
| Dunne Ferraro Limited | Wholesale & retail | 2010 |
| Duracote Realisations Limited | Water & waste | 1965 |
| DUS Holding Ltd | Financial services | 2017 |
| Dutchman PUB Company Limited | Hospitality | 2018 |
| Duxbury Property Investments Limited | Real estate | 2016 |
| Duzy Investments Ltd | Real estate | 2024 |
| DVP Optical Ltd | Manufacturing | 2018 |
| DW Boiler Servicing Limited | Construction | 2024 |
| DW Engineering HGV Ltd | Manufacturing | 2026 |
| DW Plant Services Limited | Financial services | 2018 |
| DW Utility Services Limited | Administrative & support | 2009 |
| Dwan Services Ltd | Health & social care | 2026 |
| Dwindl LLP | | 2026 |
| Dynamic Intelligence Learning UK Ltd | Education | 2015 |
| Dynasty Bar Ltd | Hospitality | 2025 |
| Dyven Limited | Information & communication | 2023 |
| DZ Transportation Ltd | Transport & logistics | 2025 |
| E & M Property Holdings Ltd | Real estate | 2017 |
| E & R Properties Limited | Real estate | 2018 |
| E F F Marketing Limited | Wholesale & retail | 2012 |
| E F Law Limited | Professional & scientific | 2015 |
| E Travel North West Ltd | Transport & logistics | 2026 |
| E-Alchemy Ltd | Information & communication | 2020 |
| E-Den Investment Services Ltd | Extraterritorial | 2009 |
| E-Z Spa Ltd | Wholesale & retail | 2021 |
| E.F.R Estates Limited | Real estate | 2020 |
| E.J. Harrison Ltd. | Construction | 2001 |
| Eagle Bridge Pharma Ltd | Wholesale & retail | 2025 |
| Eagle Catering Limited | Hospitality | 2026 |
| Eagle Lockers and Doors Limited | Manufacturing | 2008 |
| Eagle Threads Ltd | Wholesale & retail | 2021 |
| Eagle Transportation Ltd | Transport & logistics | 2021 |
| Eagleye Digital Ltd | Information & communication | 2025 |
| Eanam Law Limited | Professional & scientific | 2021 |
| Earcare Professionals Ltd | Health & social care | 2026 |
| Earl Property Group Ltd | Real estate | 2026 |
| Early Bird Coffee & Sandwich Limited | Hospitality | 2023 |
| Earth Sister Ltd | Arts & recreation | 2025 |
| Earthworks Capital Ltd | Mining & quarrying | 2023 |
| East Lancashire Apprenticeship Training Group Limited | Education | 2025 |
| East Lancashire Contraception and Surgical Services Limited | Health & social care | 2007 |
| East Lancashire Cricket Club Limited | Arts & recreation | 2022 |
| East Lancashire Electrical Ltd | Construction | 2020 |
| East Lancashire Foods Limited | Hospitality | 2018 |
| East Lancashire Home Care Limited | Health & social care | 2012 |
| East Park Florists Limited | Wholesale & retail | 2022 |
| East Park Road Management Company (Blackburn) Limited | Households | 1977 |
| Eastern Spice (NW) Ltd | Hospitality | 2026 |
| Eastridge Properties Limited | Real estate | 2001 |
| Eastwell Ventures Limited | Administrative & support | 1971 |
| Eastwood Transport and Logistics Ltd | Transport & logistics | 2022 |
| Easy Electrical & Renewables Ltd | Construction | 2025 |
| Easy Print Ltd | Manufacturing | 2019 |
| Easy Ride Transport Ltd | Transport & logistics | 2024 |
| Easy Storage Solutions Limited | Transport & logistics | 2017 |
| EASY4EVER Ltd | Wholesale & retail | 2023 |
| Easyrep (UK) Limited | Professional & scientific | 2014 |
| Eatsndeals Ltd | Information & communication | 2026 |
| Eazi PAY Products Limited | Wholesale & retail | 2022 |
| Eazyloft Ltd | Construction | 2026 |
| Ebor Originals Limited | Wholesale & retail | 2017 |
| EBP Building Products Limited | Wholesale & retail | 1929 |
| EBP EOT Limited | Financial services | 2022 |
| EBP Limited | Wholesale & retail | 2015 |
| Ecba Holdings Limited | Professional & scientific | 2016 |
| Ecba Limited | Professional & scientific | 2010 |
| Echelon Bridge Ltd | Wholesale & retail | 2023 |
| Echoes Paranormal Ltd | Arts & recreation | 2023 |
| Echowave Enterprises Ltd | Professional & scientific | 2024 |
| ECI Global Consultancy Services Ltd | Professional & scientific | 2024 |
| Eclectic Living Limited | Professional & scientific | 2017 |
| Eclipse Psychological Services Limited | Other services | 2005 |
| Eco 4 Homes Ltd | Construction | 2015 |
| Eco Britain Ltd | Administrative & support | 2017 |
| Eco Construction Northwest Ltd | Construction | 2023 |
| Eco Daily Supplies Ltd | Wholesale & retail | 2019 |