| Shadow Mgmt Ltd | Arts & recreation | 2024 |
| Shah Fortunes Ltd | Financial services | 2020 |
| Shake & Taste Bartending School Ltd | Education | 2018 |
| Shazsam Ltd | Health & social care | 2025 |
| SHC Accommodation Limited | Hospitality | 2023 |
| SHE Clears Ltd | Water & waste | 2026 |
| Shedley Richards Limited | Wholesale & retail | 2026 |
| Sheering Village Pre-School CIC | Administrative & support | 2010 |
| Shen-Qi Therapy Limited | Health & social care | 2017 |
| Shield Batteries (Northwest) Limited | Water & waste | 1930 |
| Shield Compliance Services Limited | Professional & scientific | 2017 |
| Shield Fire Consultancy Ltd | Public administration | 2014 |
| Shield VPN Ltd | Extraterritorial | 2025 |
| Shift Link Software Limited | Information & communication | 2025 |
| Shilton Property Marketing Limited | Professional & scientific | 2024 |
| Shinkar Medical Services Limited | Real estate | 2019 |
| Showman Logistics Ltd | Transport & logistics | 2026 |
| Shrogg Property Limited | Real estate | 2026 |
| Shukho Marketing Ltd | Professional & scientific | 2020 |
| SHY Dog Limited | Hospitality | 2025 |
| Si&Ar Ltd | Hospitality | 2020 |
| Si-Novation Limited | Administrative & support | 2012 |
| Sideso Ltd | Real estate | 2024 |
| Sigma Investments Limited | Real estate | 1978 |
| Sign-Tific Limited | Manufacturing | 2008 |
| Signature Details Car Care Limited | Wholesale & retail | 2021 |
| Signature Partnership Group Limited | Administrative & support | 2018 |
| Signature PPF Ltd | Wholesale & retail | 2025 |
| SIL Investments Ltd | Construction | 2023 |
| Silano Ltd | Wholesale & retail | 2017 |
| Silent Scribe Limited | Professional & scientific | 2020 |
| Sillwood Park Limited | Real estate | 2023 |
| Silva & Passos Ltd | Wholesale & retail | 2020 |
| Silvaline Ltd | Administrative & support | 2026 |
| Silver Rock Ltd | Administrative & support | 2022 |
| Silver Skink Ltd | Professional & scientific | 2023 |
| Simon Dennis (Butchers) Limited | Wholesale & retail | 2009 |
| Simon Gilbert Limited | Wholesale & retail | 2006 |
| Simon Harry COX Design Ltd | Information & communication | 2016 |
| Simou Invest Ltd | Real estate | 2025 |
| Simplest Cooking Ltd | Wholesale & retail | 2021 |
| Simply Good Decorating Ltd | Construction | 2025 |
| Simply Group Developments Ltd | Construction | 2024 |
| Simply Group Electrical Ltd | Construction | 2020 |
| Simply Serve Somerset Ltd | Information & communication | 2021 |
| Simplydoesuk Ltd | Administrative & support | 2026 |
| Sims Engineering Systems Limited | Manufacturing | 1986 |
| Sine-Wave Services Limited | Manufacturing | 2006 |
| Sirac Property Ltd | Real estate | 2020 |
| Site Electrical Components and Service Limited | Construction | 2021 |
| SJM One Services Limited | Financial services | 2016 |
| Sjme Holdings Limited | Financial services | 2013 |
| SJP Rural Ltd | Agriculture & fishing | 2020 |
| SJP Wellness Ltd | Other services | 2023 |
| SJS Engineering Services & Solutions Ltd | Professional & scientific | 2017 |
| SK Sports Ltd | Arts & recreation | 2022 |
| Skea-Strachan Limited | Financial services | 2024 |
| Skeyes Limited | Wholesale & retail | 2007 |
| SKILLS2USE Limited | Information & communication | 2015 |
| Skin School Limited | Other services | 2023 |
| Skin Soak Ltd | Wholesale & retail | 2024 |
| Skin Store Limited | Information & communication | 2023 |
| Skingle Solutions Ltd | Professional & scientific | 2024 |
| Sknd Subs Limited | Hospitality | 2013 |
| Skylight Aviation Consulting Limited | Extraterritorial | 2012 |
| Skylight Aviation LLP | | 2012 |
| Skylink Rope Access Ltd | Construction | 2023 |
| Skynet Communications Ltd | Information & communication | 2019 |
| Skypics Limited | Information & communication | 2015 |
| Skyvista Properties Ltd | Households | 2025 |
| Slav Building and Development Ltd | Construction | 2022 |
| Sleeping Mole Ltd | Hospitality | 2022 |
| SM Residential Management Ltd | Real estate | 2023 |
| Small FRY Media Limited | Professional & scientific | 2012 |
| Smalls Taverns Ltd | Hospitality | 2025 |
| Smart Cities World Limited | Information & communication | 2015 |
| SMB Drywall Ltd | Construction | 2017 |
| SMB173 Limited | Information & communication | 2015 |
| Smile and Wine Limited | Hospitality | 2024 |
| Smilehut Limited | Information & communication | 2025 |
| Smith Acres Ltd | Real estate | 2024 |
| Smithfield Accountants LLP | | 2006 |
| Smiths Plumbing and Heating Limited | Construction | 2004 |
| SMK Plumbers Ltd | Construction | 2016 |
| Smooth Surface Solutions (3S) Ltd | Construction | 2025 |
| Snapdragon Homes Limited | Real estate | 2025 |
| Snappy Croc Ltd | Hospitality | 2025 |
| Snokko Ltd | Wholesale & retail | 2025 |
| Snow Technologies Ltd | Information & communication | 2024 |
| Soar Childcare and Education Ltd | Education | 2014 |
| Soccar Limited | Extraterritorial | 1996 |
| Social Trove Limited | Professional & scientific | 2023 |
| SOCIAL8 Brands 01 Ltd | Professional & scientific | 2020 |
| SOCIAL8 Brands 02 Ltd | Professional & scientific | 2020 |
| SOCIAL8 Ltd | Professional & scientific | 2018 |
| Software Confidence Ltd | Information & communication | 2009 |
| Solid Inc. Limited | Other services | 2012 |
| Solution Executive Search LLP | | 2014 |
| Solution Financial Limited | Professional & scientific | 2019 |
| Solution Search Limited | Administrative & support | 2023 |