| R.P. Child Electrical Contractors Limited | Construction | 2006 |
| Raby Holdings Ltd | Construction | 2025 |
| Race Joinery Limited | Construction | 2017 |
| Radio Northumberland Limited | Information & communication | 2012 |
| Rafiq Takeaway Limited | Hospitality | 2024 |
| Raider Acquisitions Ltd | Financial services | 2023 |
| Ramesh 75 Ltd | Wholesale & retail | 2024 |
| Rams Head Antiques Limited | Wholesale & retail | 2015 |
| Ramshaw Builders Limited | Construction | 2010 |
| Ramshaw Logistics Ltd | Transport & logistics | 2015 |
| Ramshaw Logs and Sticks Ltd | Manufacturing | 2026 |
| Randhawa Property Management Ltd | Real estate | 2023 |
| Rapid Fire Solutions Ltd | Financial services | 2022 |
| Rascal Mouse Ltd | Wholesale & retail | 2019 |
| Ratnam 75 Ltd | Wholesale & retail | 2026 |
| Rawry Limited | Construction | 2009 |
| Rawry Services Ltd | Extraterritorial | 2023 |
| RAY Healthcare Cooperation Limited | Health & social care | 2025 |
| RCS Domiciliary Agency Ltd | Administrative & support | 2022 |
| RCT Stoves Ltd | Construction | 2023 |
| RDH 821 Limited | Hospitality | 2024 |
| RDH Property North East Ltd | Real estate | 2025 |
| Re-Ignite Property Solutions Ltd | Construction | 2025 |
| Readman Fabrications Limited | Manufacturing | 2012 |
| Rebo Fade Ltd | Other services | 2025 |
| Recovery Technical Management Ltd | Construction | 2011 |
| Red Five Engineering & Design Ltd | Professional & scientific | 2022 |
| Red Hurworth Leisure Limited | Hospitality | 2020 |
| Red Rose Realty Limited | Extraterritorial | 2014 |
| Redfern Building Services Limited | Construction | 1990 |
| Redfern Holdings (North East) Limited | Financial services | 2023 |
| Redworth QS Services Ltd | Professional & scientific | 2017 |
| Regal Group NE Ltd | Construction | 2022 |
| Regor Limited | Wholesale & retail | 2014 |
| Relm Haulage Ltd | Wholesale & retail | 2025 |
| Renaissance NE C.I.C. | Real estate | 2021 |
| Renoright Ltd | Construction | 2023 |
| Reputable Services Limited | Administrative & support | 2016 |
| Resha Ltd | Wholesale & retail | 2016 |
| Resolve (Care Northern) Limited | Health & social care | 2008 |
| Resolve Contracts Ltd | Construction | 2024 |
| Resolve Group UK Ltd | Construction | 2025 |
| Resonator Ltd | Professional & scientific | 2019 |
| Resource Plastics Limited | Wholesale & retail | 2005 |
| Resqsupport Limited | Public administration | 2017 |
| Retail Leap Limited | Professional & scientific | 2024 |
| Revenio Consulting Ltd | Administrative & support | 2013 |
| Revival Homes Ltd | Construction | 2015 |
| Revival HQ Limited | Wholesale & retail | 2021 |
| REY Medical Ltd | Health & social care | 2025 |
| RG1 Management Limited | Professional & scientific | 2025 |
| Riad Chayma Ltd | Hospitality | 2011 |
| Rich Tone Maintenance Ltd | Construction | 2025 |
| Riding Centre for Special People Ltd | Arts & recreation | 2016 |
| Ridley Exhausts Limited | Wholesale & retail | 2004 |
| Ridley House Apartments Ltd | Hospitality | 2024 |
| Rigg Investments Limited | Financial services | 2022 |
| Rizdar Properties Limited | Real estate | 2013 |
| RJY Investments (North East) Ltd | Financial services | 2014 |
| RK Customize Ltd | Wholesale & retail | 2024 |
| RLA Leisure Ltd | Hospitality | 2024 |
| RLB Property & Development Ltd | Real estate | 2024 |
| RLD and Sons Ltd | Agriculture & fishing | 2021 |
| RMH Car Sales Limited | Wholesale & retail | 2015 |
| RMH Vehicle Services Limited | Wholesale & retail | 2020 |
| RMK Property North East Limited | Real estate | 2020 |
| RNB Roofing Supplies Limited | Wholesale & retail | 2025 |
| Robertson Financial Services Limited | Financial services | 2021 |
| Robsons of Wolsingham Limited | Wholesale & retail | 1975 |
| Rockett Groundworks Ltd | Construction | 2022 |
| Rockinghorse Avenue (Pickhill) Management Company Limited | Real estate | 2022 |
| Rockley Grange Management Company Limited | Households | 2020 |
| Rockwood Motor Group Ltd | Wholesale & retail | 2026 |
| Rogers Property Investments Ltd | Real estate | 2022 |
| Rogue BA Ltd | Other services | 2025 |
| Rollo Carter Ltd | Information & communication | 2024 |
| Rookhope Kitchen Ltd | Hospitality | 2025 |
| Rooster Enterprises Limited | Financial services | 2005 |
| Rose a Farms Limited | Agriculture & fishing | 2022 |
| Roseberry Park (Hessle) Management Company Limited | Households | 2018 |
| Rosemarie Ltd | Real estate | 2017 |
| Rosemount Court Management Company Limited | Households | 1991 |
| Rosewoods Management Company Limited | Households | 2015 |
| Rouxel Transport Management Ltd | Professional & scientific | 2024 |
| Roxy Beauty Ltd | Other services | 2019 |
| Royalington Properties Ltd | Real estate | 2026 |
| Rqss Ltd | Professional & scientific | 2025 |
| Russell Street Management Company Limited | Extraterritorial | 2001 |
| Russon Consultancy Ltd | Administrative & support | 2015 |
| Rwp&H UK Limited | Professional & scientific | 2024 |
| Ryan Cole Machinery Limited | Wholesale & retail | 2013 |
| Ryan Cooper Ltd | Wholesale & retail | 2025 |
| Ryan Engineering Ltd | Manufacturing | 2025 |
| Ryan James Estate Agents Ltd | Real estate | 2020 |
| Rydec Painting & Decorating Limited | Construction | 2025 |
| S & E Weston Limited | Wholesale & retail | 2003 |
| S & P Landscaping Ltd | Administrative & support | 2026 |
| S a Brickwork Ltd | Construction | 2017 |
| S a Real-Estate NE Ltd | Real estate | 2025 |
| S and S Site Services Limited | Water & waste | 2002 |