| Empowered Pathways Group Ltd | Professional & scientific | 2025 |
| Empowered Transport Limited | Information & communication | 2012 |
| Empowerhim CIC | Health & social care | 2024 |
| Empowering Behaviour Change Ltd | Professional & scientific | 2024 |
| Empowering Black Children and Families Ltd | Health & social care | 2018 |
| Empowering Hands Ltd | Administrative & support | 2025 |
| Empowering Lives Housing Ltd | Real estate | 2026 |
| Empowering People in Change Training Ltd | Education | 2025 |
| Empowering Your Life CIC | Other services | 2024 |
| Empowerment Body Ltd | Education | 2025 |
| Empowerment Coach DON Ltd | Arts & recreation | 2023 |
| Empowerone Limited | Arts & recreation | 2025 |
| Empress Acquisitions Ltd | Extraterritorial | 2025 |
| Empress Living Estates Ltd | Real estate | 2026 |
| Empress T & Emperor T Limited | Wholesale & retail | 2021 |
| Empresses Goddesses & Queens Ltd | Education | 2021 |
| Emprowe Energy Ltd | Construction | 2017 |
| Empyrean Global Trading Limited | Manufacturing | 2024 |
| EMR Services Ltd | Construction | 2025 |
| Emrain Ltd | Wholesale & retail | 2020 |
| Emran Meah Ltd | Transport & logistics | 2024 |
| Emrd House Limited | Real estate | 2026 |
| Emrs U.K Limited | Wholesale & retail | 2019 |
| EMS Housing Limited | Hospitality | 2021 |
| Emsart Ltd | Arts & recreation | 2025 |
| Emscot Limited | Real estate | 2010 |
| Emsley Contractors Ltd | Professional & scientific | 2025 |
| Emsons Limited | Administrative & support | 2021 |
| EMT Applied Technology Ltd | Information & communication | 2019 |
| Emtamang.Com Ltd | Other services | 2022 |
| EMU Medical Limited | Health & social care | 2023 |
| Emubay Limited | Wholesale & retail | 2025 |
| Emunah Recruitment Ltd | Administrative & support | 2023 |
| EMY Transport Services Limited | Transport & logistics | 2025 |
| Emye Consultants Ltd | Information & communication | 2025 |
| Emyt Limited | Health & social care | 2017 |
| Emzed Investments Limited | Financial services | 2021 |
| Emzibah Care Services Limited | Health & social care | 2024 |
| EN Property (Bromsgrove) Ltd | Real estate | 2024 |
| EN Route Traffic Management Limited | Other services | 2025 |
| EN Route Transport Ltd | Transport & logistics | 2024 |
| EN Vogue Childrens Ltd | Construction | 2016 |
| EN Vogue Interiors Ltd | Construction | 2016 |
| Enable (WM) Limited | Health & social care | 2021 |
| Enable Housing Ltd | Real estate | 2019 |
| Enable Rehab Ltd | Health & social care | 2019 |
| Enable Wellness Consultancy Ltd | Health & social care | 2019 |
| Enableelite CIC | Public administration | 2024 |
| Enablelink Limited | Water & waste | 2007 |
| Enably Group Ltd | Information & communication | 2024 |
| Enado Limited | Information & communication | 2008 |
| Enamel Works Freehold Ltd | Real estate | 2025 |
| Enamel Works Ltd | Real estate | 2025 |
| Encasa Group Holdings Limited | Financial services | 2021 |
| Encasa Group Limited | Real estate | 2016 |
| Encasa Sales & Lettings Limited | Real estate | 2023 |
| Encass Limited | Professional & scientific | 2011 |
| Encee Consulting Limited | Professional & scientific | 2015 |
| Enchanted Treasures Limited | Wholesale & retail | 2024 |
| Enchanted Ventures Ltd | Hospitality | 2021 |
| Enchris Solutions Limited | Information & communication | 2025 |
| Enclosed Reach Recruitment Ltd | Administrative & support | 2025 |
| Encods Trade and Consultancy Ltd | Wholesale & retail | 2021 |
| Encompass Cloud Consulting Limited | Information & communication | 2022 |
| Encompass Financial Management Ltd | Financial services | 2004 |
| Encore (NNS) Limited | Extraterritorial | 2004 |
| Encore Hair & Beauty Ltd | Other services | 2022 |
| Encore OIL Limited | Mining & quarrying | 1997 |
| Encore Print Management Limited | Financial services | 2004 |
| Encore Processing Solutions Limited | Professional & scientific | 2024 |
| Encore Stage School Ltd | Arts & recreation | 2019 |
| Encoremnd Ltd | Information & communication | 2024 |
| Encores Tire&Wheel UK Ltd | Wholesale & retail | 2025 |
| Encouragemint Ltd | Agriculture & fishing | 2022 |
| Encouraging Lives CIC | Hospitality | 2021 |
| END of Weak Ltd | Education | 2022 |
| END Trading Limited | Wholesale & retail | 2026 |
| Endallit Limited | | 1987 |
| Endear Homes Ltd | Real estate | 2024 |
| Endeavour Bidco Limited | Administrative & support | 2021 |
| Endeavour Housing Ltd | Real estate | 2025 |
| Endeavour Intercity Limited | Wholesale & retail | 2022 |
| Endesk Ltd | Information & communication | 2010 |
| Endless Enterprises Limited | Real estate | 2022 |
| Endless Finds Ltd | Wholesale & retail | 2024 |
| Endo Management Ltd | Administrative & support | 2019 |
| Endodontic Excellence Limited | Health & social care | 2024 |
| Endodontic Services and Consultancy Ltd | Health & social care | 2015 |
| Endorsings Ltd | Education | 2026 |
| Endoscope-I Ltd | Health & social care | 2012 |
| Endoscript Ltd | Information & communication | 2026 |
| Endure Housing CIC | Real estate | 2025 |
| Endure Vision Ltd | Wholesale & retail | 2023 |
| Endwood Estates Ltd | Real estate | 2025 |
| Enea International Transport Limited | Transport & logistics | 2019 |
| Eneft Limited | Administrative & support | 2012 |
| Enemio Limited | Wholesale & retail | 2022 |
| Energas Limited | Wholesale & retail | 1981 |
| Energetiq Advisory Ltd | Wholesale & retail | 2025 |
| Energia Creations Limited | Manufacturing | 2025 |