| Seven Happy Ltd | Hospitality | 2024 |
| Sevlow Cleaning Contractors Ltd | Administrative & support | 2021 |
| SGK Distribution Ltd | Wholesale & retail | 2016 |
| SGK Recycling Solutions Ltd | Water & waste | 2021 |
| Sgnco Resources Limited | Professional & scientific | 2022 |
| Shabad Properties Ltd | Real estate | 2025 |
| Shaft Motors Limited | Wholesale & retail | 2019 |
| Shahan UK Ltd | Professional & scientific | 2023 |
| Shamba Gardener Ltd | Arts & recreation | 2024 |
| Shan (Midlands) Ltd | Arts & recreation | 2016 |
| Sharma Holdings Ltd | Financial services | 2022 |
| Sharps Bedrooms Limited | Manufacturing | 2011 |
| Sharps Furniture Group Limited | Manufacturing | 2025 |
| Sheemar Transport Limited | Transport & logistics | 2025 |
| SHEM1 Property Portfolio Limited | Real estate | 2025 |
| Sherridan-Yasharahla Dawkins Limited | Extraterritorial | 2025 |
| Shine Social Care Services Ltd | Health & social care | 2025 |
| Shire Pressings Limited | Manufacturing | 1993 |
| Shjm Consultancy Ltd | Professional & scientific | 2025 |
| Shop Epic Ltd | Wholesale & retail | 2025 |
| Show Plates Ltd | Wholesale & retail | 2020 |
| Sibba Haulage Ltd | Transport & logistics | 2026 |
| Sichern Hardware Limited | Wholesale & retail | 2020 |
| Siddab UK Limited | Wholesale & retail | 2025 |
| Sidhu Construction Midland Ltd | Construction | 2022 |
| Sidhu Logistics Ltd | Transport & logistics | 2018 |
| Sidhu Prime Couriers Ltd | Transport & logistics | 2026 |
| Signs Tech Ltd | Manufacturing | 2018 |
| Sikh Temple (Shinda Batth) UTD Kabaddi Club W'Ton Ltd | Other services | 2024 |
| Silk and Shine Ltd | Wholesale & retail | 2018 |
| Silver FOX Bar & Grill Ltd | Hospitality | 2024 |
| Silverstem Healthcare Ltd | Public administration | 2023 |
| Simar International Limited | Professional & scientific | 2016 |
| Simple Fitness (UK) Ltd | Other services | 2019 |
| Simple Retail Solutions Ltd | Construction | 2023 |
| Simple Solution SS Ltd | Professional & scientific | 2020 |
| Simply Foam Products Limited | Manufacturing | 2000 |
| Singhz Training Ltd | Education | 2025 |
| SJ Manson Financial Planning Ltd | Professional & scientific | 2024 |
| SJL Glazing Ltd | Construction | 2021 |
| SJW Business Coaching Limited | Professional & scientific | 2025 |
| SK Design Delivery Services Limited | Information & communication | 2019 |
| SKD & Daughters Ltd | Real estate | 2026 |
| Skill Crafting Limited | Manufacturing | 2025 |
| Skills 4 Careers Ltd | Education | 2025 |
| Sky Blue Engraving Ltd | Arts & recreation | 2025 |
| Skybound Properties Ltd | Real estate | 2024 |
| Skyline Catering Ltd | Hospitality | 2011 |
| Skypower Ventures Limited | Real estate | 2026 |
| SL Adamus Ltd | Transport & logistics | 2021 |
| SL Interiors Limited | Construction | 2019 |
| SLB Ltd | Real estate | 2021 |
| Slice N Scoop Ltd | Hospitality | 2022 |
| Slish Services Limited | Professional & scientific | 2017 |
| Slpb 1 Ltd | Construction | 2024 |
| Smart Body Work and Repair Ltd | Wholesale & retail | 2024 |
| Smart Car Automotive Ltd | Manufacturing | 2013 |
| Smart Car Performance Centre Limited | Wholesale & retail | 2020 |
| Smart Car Training Academy Ltd | Wholesale & retail | 2018 |
| Smart Car Training Centre Ltd | Manufacturing | 2020 |
| Smart Repair (UK) Limited | Wholesale & retail | 2013 |
| Smartglaze UK Ltd | Construction | 2021 |
| Smiling Art Ltd | Health & social care | 2015 |
| Smith & Oakley Imports Limited | Wholesale & retail | 2012 |
| Smiths Transport Solutions Ltd | Transport & logistics | 2008 |
| SMK Transport Ltd | Transport & logistics | 2019 |
| SMN9 Ltd | Administrative & support | 2025 |
| SNE Contractors Ltd | Construction | 2024 |
| SO Influenced Limited | Other services | 2024 |
| Sobitech Ltd | Other services | 2025 |
| Social Impact Research Ltd | Professional & scientific | 2018 |
| Socialyn Ltd | Wholesale & retail | 2025 |
| Soda Blasting Limited | Administrative & support | 2020 |
| Soho Concrete and Liquid Screed Ltd | Manufacturing | 2025 |
| Solo Singh Ltd | Transport & logistics | 2021 |
| SOLUTIONS4PLANNING Limited | Information & communication | 2008 |
| Soomal Haulage Ltd | Transport & logistics | 2018 |
| Soulmates Pet Wellness & Beauty Ltd | Other services | 2024 |
| Sound Mind @ GRACE2GRACE C.I.C. | Health & social care | 2023 |
| South Staffordshire Training Association Limited(The) | Other services | 1985 |
| Sovereign Products Ltd | Wholesale & retail | 2020 |
| SP Freightway Limited | Transport & logistics | 2019 |
| SP212 Limited | Professional & scientific | 2024 |
| Specialist Windows and Doors Ltd | Construction | 2019 |
| Spectral Group Ltd | Extraterritorial | 2026 |
| Spectral Marketing Ltd | Information & communication | 2026 |
| Spectral Technology Ltd | Information & communication | 2025 |
| Spectrum 3T Network Ltd | Wholesale & retail | 2023 |
| Speed 2888 Limited | Real estate | 1992 |
| Speedy Online Limited | Wholesale & retail | 2019 |
| Speedy Swift Logistics Ltd | Transport & logistics | 2025 |
| Spencers Cafe Limited | Hospitality | 2003 |
| SPL Retail Limited | Wholesale & retail | 2013 |
| Spring Homes Limited | Construction | 2006 |
| Sprintech UK Ltd | Arts & recreation | 2024 |
| SS Golden Ltd | Transport & logistics | 2020 |
| SSA Mixy Ltd | Hospitality | 2025 |
| SSB Trading Ltd | Wholesale & retail | 2023 |
| SSF Building Contractors Limited | Construction | 2015 |
| SSF Metal Products Limited | Manufacturing | 2015 |