| RU Properties Ltd | Wholesale & retail | 2019 |
| Rubis Convenience Store Ltd | Wholesale & retail | 2022 |
| Ruby House 53 Limited | Hospitality | 2023 |
| Rudorwashe Limited | Public administration | 2018 |
| RW Property Progress Limited | Real estate | 2015 |
| RXR International Limited | Wholesale & retail | 2020 |
| Ryan Details Car Care Ltd | Wholesale & retail | 2023 |
| Ryan Details Ltd | Wholesale & retail | 2017 |
| S & B Upholstery Ltd | Manufacturing | 2021 |
| S & G Housing Ltd | Real estate | 2024 |
| S & J Glazing Ltd | Construction | 2025 |
| S & S Stores (Wolverhampton) Limited | Wholesale & retail | 2019 |
| S K Immigration Ltd | Administrative & support | 2024 |
| S Lynch Financial Ltd | Professional & scientific | 2025 |
| S N S Electrical Limited | Construction | 2014 |
| S S Concrete Pumping Ltd | Construction | 2008 |
| S&A Car Parts & Recovery Ltd | Wholesale & retail | 2023 |
| S&C Chouhan Limited | Real estate | 2026 |
| S&D Midlands Transport Ltd | Transport & logistics | 2020 |
| S&G FS Ltd | Financial services | 2025 |
| S&L Midland Properties Ltd | Administrative & support | 2023 |
| S. J. F. Designs Limited | Construction | 1994 |
| SA Dental Limited | Health & social care | 2015 |
| Saaarj Logistics Ltd | Transport & logistics | 2024 |
| Saabinder Ltd | Transport & logistics | 2023 |
| Sabeero Ltd | Wholesale & retail | 2020 |
| Sachdeva Limited | Wholesale & retail | 2025 |
| Saffron Sausage Ltd | Hospitality | 2026 |
| Sahota Property Ltd | Real estate | 2021 |
| Saiji Limited | Hospitality | 2019 |
| Sala Imaging Limited | Extraterritorial | 1986 |
| Sala Integrated Information Management Limited | Extraterritorial | 2010 |
| Salford & Smitt Co Limited | Wholesale & retail | 2025 |
| Salia Naturals Limited | Health & social care | 2021 |
| Salisbury Poultry (Midlands) Limited | Manufacturing | 1995 |
| Salisbury Poultry Limited | Extraterritorial | 2009 |
| Salop Street Property Limited | Real estate | 2012 |
| SAM RO Trading Ltd | Manufacturing | 2023 |
| SAM Trans Ltd | Transport & logistics | 2025 |
| Samisam Limited | Wholesale & retail | 2025 |
| Samix Cars Limited | Wholesale & retail | 2018 |
| Samoco Ltd | Professional & scientific | 2024 |
| SAN Contractors Ltd | Construction | 2014 |
| Sandhu Investment Property Group Limited | Real estate | 2025 |
| Sandhu Services Ltd | Construction | 2024 |
| Sandhu SK Transport Ltd | Transport & logistics | 2024 |
| Sandhu Steel Fabrications Limited | Manufacturing | 2025 |
| Sandland Packaging Group Limited | Manufacturing | 2005 |
| Sandland Packaging Holdings Limited | Manufacturing | 2019 |
| Sandland Packaging Limited | Manufacturing | 1988 |
| Sandrah Investments Ltd | Financial services | 2023 |
| Sandwell Sports Limited | Wholesale & retail | 2020 |
| Sangha Builder & Double Glazing Ltd | Construction | 2019 |
| Sangha Garages T/A Millfields Auto Service Limited | Wholesale & retail | 2024 |
| Sanjay Patel Ltd | Extraterritorial | 2025 |
| Santon Homecare Ltd | Administrative & support | 2025 |
| Sanyaalex Ltd | Construction | 2015 |
| Saparis Ltd | Manufacturing | 2023 |
| Sarabadu Ltd | Professional & scientific | 2013 |
| Sarah BEE Limited | Wholesale & retail | 2024 |
| Sarai & Khaira Construction Ltd | Construction | 2023 |
| Sarai Interior Accessories Ltd | Construction | 2023 |
| Sarb Uttam Kitchen Limited | Hospitality | 2026 |
| Sarkot Builder Ltd | Construction | 2026 |
| Sarn Radiant Ltd | Administrative & support | 2025 |
| Sarpanch Transport Ltd | Transport & logistics | 2026 |
| Sarrj Mart Enterprise Ltd | Wholesale & retail | 2026 |
| SAS Electrical Contractors Limited | Construction | 2005 |
| SAS Entertainments & Events Ltd | Arts & recreation | 2018 |
| SAT Guru Hardware and Tools Ltd | Wholesale & retail | 2025 |
| Satina Limited | Transport & logistics | 2017 |
| Satyam Builders Ltd | Construction | 2024 |
| Savicleean Limited | Administrative & support | 2025 |
| Sazelle Ltd | Wholesale & retail | 2026 |
| Sbjs Logistics Ltd | Transport & logistics | 2025 |
| SC Supply Group Ltd | Administrative & support | 2024 |
| SCA Health Ltd | Health & social care | 2025 |
| Scaffold & Construction Products Limited | Manufacturing | 2001 |
| Scan Image Solutions UK Limited | Extraterritorial | 2006 |
| Scarletwhispers Ltd | Wholesale & retail | 2025 |
| Schatten Logistics Ltd | Transport & logistics | 2020 |
| Schatten Services Ltd | Construction | 2019 |
| Scoffs Fish and Chips Ltd | Hospitality | 2026 |
| Scott James Fitness Limited | Other services | 2011 |
| Screed and That Limited | Construction | 2020 |
| SD Heating and GAS Limited | Construction | 2020 |
| Sdsca Limited | Health & social care | 2014 |
| SE53 Enterprises Ltd | Wholesale & retail | 2025 |
| Searle and Fraser Limited | Wholesale & retail | 1981 |
| Seating Works Ltd | Administrative & support | 2014 |
| Secron Global Resources Ltd | Wholesale & retail | 2024 |
| Secure Fasteners (Midlands) Limited | Wholesale & retail | 1984 |
| Secure Shift Logistics Ltd | Transport & logistics | 2025 |
| Sektrans Limited | Transport & logistics | 2021 |
| Select Alarm Systems Limited | Administrative & support | 1981 |
| SELER8 Ltd | Administrative & support | 2022 |
| Sembhi Transport Ltd | Transport & logistics | 2017 |
| Senshi Tokyo Ltd | Wholesale & retail | 2025 |
| Sepia Films Limited | Information & communication | 2004 |
| Serial Gifter Ltd | Wholesale & retail | 2025 |