| Shamim Family Partnership LLP | | 2021 |
| Shapes Electrical Ltd | Professional & scientific | 2022 |
| Sharif Family Holding Ltd | Real estate | 2016 |
| Sharif Family Partnership LLP | | 2016 |
| Shaunak Family Holdings Ltd | Real estate | 2018 |
| Shaunak Family Partnership LLP | | 2018 |
| Shawsminibustravel Ltd | Transport & logistics | 2026 |
| Shears Family Holdings Ltd | Real estate | 2018 |
| Shears Family Partnership LLP | | 2018 |
| Sheila & Harry Ltd | Real estate | 2017 |
| Sheila & Harry Partnership LLP | | 2017 |
| Shepard Family Holdings Ltd | Real estate | 2021 |
| Shepard Family Partnership LLP | | 2021 |
| Shepherd Electrical Services Twin & Earth Ltd | Construction | 2022 |
| Sheriff Mount North Freehold Limited | Real estate | 2021 |
| Shika Arcades Ltd | Manufacturing | 2017 |
| Shivani Shaunak LLP | | 2019 |
| Shomimo Ltd | Real estate | 2025 |
| Shonette Bason Ltd | Education | 2010 |
| Shonette's Nurseries Ltd | Professional & scientific | 2023 |
| Shovlin Family Holdings Ltd | Real estate | 2020 |
| Shovlin Family Partnership LLP | | 2020 |
| Siamo PAY Limited | Administrative & support | 2019 |
| SIB Consult Ltd | Professional & scientific | 2019 |
| SID Property Management Ltd | Real estate | 2010 |
| Signature Peptides Ltd | Wholesale & retail | 2025 |
| Silver Fern Commerce Ltd | Wholesale & retail | 2026 |
| Silver FOX Project Planning Limited | Construction | 2022 |
| Silver Thames Limited | Real estate | 2016 |
| Silverin Limited | Information & communication | 2011 |
| SIM Explore Limited | Professional & scientific | 2013 |
| Simmonds Construction Solutions Limited | Construction | 2025 |
| Simplyaamazing Ltd | Other services | 2025 |
| Simpson Coulson Limited | Construction | 2012 |
| Simpson Family Holdings Ltd | Real estate | 2018 |
| Simpson Family Partnership LLP | | 2018 |
| Simpson Medical Ltd | Health & social care | 2024 |
| Simz Global Ltd | Wholesale & retail | 2025 |
| Sinan Investments Limited | Real estate | 2025 |
| Sinclarity Holdings Ltd | Financial services | 2020 |
| Singh Family Holdings Ltd | Real estate | 2016 |
| Singh Family Partnership LLP | | 2016 |
| Sipp Group LLP | | 2023 |
| Sipp Holdings Limited | Real estate | 2023 |
| Sith & REI Ltd | Real estate | 2019 |
| Situate AI Ltd | Information & communication | 2026 |
| SJ Cardiology Care Ltd | Health & social care | 2025 |
| Sjgh Services Limited | Professional & scientific | 2023 |
| SJH Sports Investments Limited | Arts & recreation | 2024 |
| SJS Financial Consulting Ltd | Financial services | 2014 |
| SK Laundry Services Limited | Other services | 2024 |
| Skeldon Consulting Ltd | Professional & scientific | 2025 |
| Skelwith Consulting Ltd | Professional & scientific | 2020 |
| Skin RX Aesthetics Clinic Limited | Other services | 2024 |
| Skits and Giggles Ltd | Arts & recreation | 2021 |
| SKN Aesthetics Ltd | Health & social care | 2022 |
| SKN Holdings Ltd. | Real estate | 2022 |
| Skytec Global Ltd | Professional & scientific | 2013 |
| Skytographer Productions Limited | Information & communication | 2017 |
| SL Pipework Services Ltd | Construction | 2024 |
| Slcr Associates Limited | Professional & scientific | 2022 |
| Sleepy Hollow Spirits Ltd | Manufacturing | 2019 |
| SLH Inspections Ltd | Construction | 2023 |
| Slqs Limited | Professional & scientific | 2012 |
| SM Project Engineering Limited | Professional & scientific | 2022 |
| SM Rigging & Erecting Limited | Construction | 2019 |
| Smalltown Holdings Ltd | Real estate | 2023 |
| Smart Energy North East Limited | Construction | 2024 |
| Smart Pizzeria Ltd | Hospitality | 2025 |
| Smarthealthconsultancy Limited | Professional & scientific | 2024 |
| Smiles North East Ltd | Education | 2016 |
| Smith Couriers 85 Ltd | Transport & logistics | 2026 |
| SMK Dynamics Ltd | Professional & scientific | 2025 |
| Smokestack Guitars Limited | Wholesale & retail | 2024 |
| SMP Engineering Services Limited | Construction | 2015 |
| SND Associates Ltd | Real estate | 2021 |
| SNS Trading Services Ltd | Wholesale & retail | 2022 |
| Social Sports Manager Limited | Information & communication | 2018 |
| Soleas Family Holdings Ltd | Real estate | 2017 |
| Soleas Family Partnership LLP | | 2017 |
| Solidus Construction Management Ltd | Real estate | 2025 |
| Solwyte Studio Ltd | Wholesale & retail | 2023 |
| Sorb Environmental (UK) Limited | Wholesale & retail | 2018 |
| Soul Control Limited | Information & communication | 2017 |
| Soulspire Care Agency Limited | Health & social care | 2023 |
| Soulspire Living Limited | Households | 2026 |
| Sound IT OUT Records Limited | Wholesale & retail | 2014 |
| Sounique Child Ltd | Administrative & support | 2012 |
| South View Convenience Store Ltd | Wholesale & retail | 2019 |
| Southbanker Limited | Professional & scientific | 2006 |
| Spa Construction and Maintenance Ltd | Construction | 2020 |
| Sparkrock Strategies Ltd | Financial services | 2025 |
| Sparksafe Ltd | Construction | 2023 |
| Sparrow Electrical Estimating Limited | Construction | 2023 |
| Sparsh Madan Innovations Ltd | Information & communication | 2013 |
| Sparshmadan Real Estates Ltd | Real estate | 2025 |
| Spck LLP | | 2011 |
| Specialist Engineering Services (NE) Ltd | Professional & scientific | 2017 |
| Specter Lynd Ltd | Professional & scientific | 2024 |
| Spectrum (PCK) Limited | Financial services | 2007 |