| Dusky Deer Ltd | Health & social care | 2014 |
| DWH Dack Limited | Agriculture & fishing | 2024 |
| Dymarke Precision Engineering Ltd | Manufacturing | 2019 |
| E T Holdings Limited | Professional & scientific | 1994 |
| E.D.S Groundworks Ltd | Construction | 2021 |
| E.J. Snell and Sons Holdings Ltd | Financial services | 2022 |
| E.J. Snell and Sons Limited | Wholesale & retail | 1964 |
| Earth Friendly Foodware Ltd | Wholesale & retail | 2017 |
| Earth Runs CIC | Arts & recreation | 2021 |
| East Browns Energy Ltd | Manufacturing | 2014 |
| East of Water Ltd | Hospitality | 2020 |
| Eastacombe Eggs Limited | Agriculture & fishing | 2018 |
| Eastlen Limited | Construction | 1996 |
| EB Inspection Limited | Professional & scientific | 2018 |
| Ebah Ltd | Administrative & support | 2023 |
| EC Digital Ltd | Professional & scientific | 2024 |
| ECN (UK) Limited | Construction | 2001 |
| Ecoserve (Southwest) Ltd | Construction | 2021 |
| Eddie Pollit Grab Hire Ltd | Water & waste | 2015 |
| Eddie Staines Limited | Construction | 2019 |
| EG Heating Ltd | Construction | 2024 |
| EG Plumbing Ltd | Construction | 2022 |
| EG Renovations Ltd | Households | 2024 |
| Egrist Ltd | Information & communication | 2018 |
| Eidos Concept Limited | Information & communication | 2025 |
| Elegant Arrivals Limited | Administrative & support | 2015 |
| Elemental Jewellery Ltd | Manufacturing | 2025 |
| Elementaries Ltd | Extraterritorial | 2023 |
| Emily Linh Nails & Beauty Training Academy Ltd | Other services | 2024 |
| Emma Morris Ltd | Wholesale & retail | 2024 |
| Emmnry Limited | Real estate | 2019 |
| Empower Devon CIC | Education | 2026 |
| EMS (SW) Ltd | Construction | 2009 |
| Emspire Care Ltd | Health & social care | 2026 |
| Enchanted Weddings & Events Limited | Other services | 2024 |
| Endura GAS Limited | Energy | 2015 |
| Endycross LLP | | 2018 |
| Energien UK Ltd | Wholesale & retail | 2020 |
| Energreen Ventures Limited | Professional & scientific | 2006 |
| English A-Z Limited | Professional & scientific | 2012 |
| Enskat Limited | Professional & scientific | 2012 |
| Epitome Productions Ltd | Manufacturing | 2023 |
| Epnic Energy Limited | Other services | 2025 |
| Eppur Renewables Limited | Other services | 2025 |
| EPR Tuning SW Ltd | Professional & scientific | 2022 |
| Erwood & Associates Limited | Professional & scientific | 2006 |
| Eseno Ltd | Wholesale & retail | 2009 |
| Esnouf Enterprises Ltd | Real estate | 2019 |
| Estuary Terrace Land Holdings Limited | Other services | 2015 |
| Estuary View Homes Limited | Real estate | 2013 |
| European Media Marketing Limited | Arts & recreation | 1995 |
| Evans Transport Limited | Transport & logistics | 1947 |
| Everything Blockchain Ltd | Wholesale & retail | 2021 |
| Everything Westward Ltd | Wholesale & retail | 2018 |
| Evolving Events CIC | Arts & recreation | 2025 |
| EX39 Ltd | Wholesale & retail | 2024 |
| Exclamation Youth Theatre CIC | Arts & recreation | 2025 |
| Executive Management Assist Ltd | Professional & scientific | 2006 |
| Exeter Engineering Limited | Professional & scientific | 2025 |
| Face Edge Limited | Manufacturing | 1998 |
| Fairlinch Camping Limited | Hospitality | 2023 |
| Fast Lane Motors Limited | Wholesale & retail | 2008 |
| Fearnley Lott Architects LLP | | 2022 |
| Fenchurch Services Ltd | Administrative & support | 2016 |
| Field Families CIC | Education | 2024 |
| Fifty Crates of Crafts Limited | Wholesale & retail | 2024 |
| Fineline Environmental Ltd | Administrative & support | 2009 |
| Finnfox Ltd | Financial services | 2004 |
| Fire Protection Systems (SW) Limited | Administrative & support | 2005 |
| Firefly Limited | Professional & scientific | 1994 |
| First 4 Flooring (SW) Limited | Construction | 2015 |
| First Raleigh Management Limited | Households | 2005 |
| Fishleighs of Galsworthy Limited | Agriculture & fishing | 2019 |
| Fixer Aviation Limited | Wholesale & retail | 2025 |
| FJF Consulting Ltd | Professional & scientific | 2007 |
| Flame and Dough Limited | Hospitality | 2021 |
| Flemings Freight Ltd | Transport & logistics | 2020 |
| Flexiservices Ltd | Professional & scientific | 2021 |
| Follyfoot Equestrian LLP | | 2023 |
| Footprint Energy Assessments Ltd | Professional & scientific | 2007 |
| Forgotten Freedom Ltd | Arts & recreation | 2016 |
| Foseti Management Ltd | Public administration | 2026 |
| Fosfelle Cottages Ltd | Hospitality | 2021 |
| Fosfelle Glamping Ltd | Hospitality | 2021 |
| Foulkes Jackson Fewings Ltd | Professional & scientific | 2025 |
| Four by Four Giveaways Ltd | Wholesale & retail | 2025 |
| Four Seasons Cottage LLP | | 2022 |
| Four Square Bowes Ltd | Manufacturing | 2015 |
| Foxdown Telecoms Ltd | Information & communication | 2019 |
| Foxlee Homes Limited | Construction | 2021 |
| Francis Agri Engineering Ltd | Professional & scientific | 2025 |
| Freedom Veterinary Advisory Services Limited | Professional & scientific | 2019 |
| Fresh Green Perspectives C.I.C. | Education | 2022 |
| Frilioth Limited | Wholesale & retail | 2024 |
| From the Printcess Limited | Manufacturing | 2021 |
| Front Runner Mortgages Ltd | Financial services | 2026 |
| Fudgies Bakehouse Limited | Wholesale & retail | 2010 |
| Fulfilled Being Ltd | Health & social care | 2017 |
| Furniture Template Ltd | Wholesale & retail | 2025 |
| Furze Game Limited | Agriculture & fishing | 2011 |