| Care Analytics (UK) Ltd | Professional & scientific | 2018 |
| Care for the Rare Limited | Professional & scientific | 2016 |
| Carer Careers Ltd | Administrative & support | 2022 |
| Carnegie Flats Management Services (Northam) Limited | Hospitality | 1978 |
| Carnival Arts North Devon Ltd | Health & social care | 2022 |
| Carradale 1 Limited | Real estate | 2021 |
| Carradalelondon Ltd | Real estate | 2026 |
| Cassandra Chessum Interior Design Limited | Professional & scientific | 2021 |
| Cast Angling Ltd | Wholesale & retail | 2024 |
| Castleacre Leisure Limited | Real estate | 2002 |
| Cat Innovations Ltd | Professional & scientific | 2002 |
| Causeway House (Bideford) Residents Association Limited | Households | 1970 |
| Centre for Mental Wellness Ltd | Health & social care | 2022 |
| Cephas Nanomed Ltd | Real estate | 2011 |
| Cfldn Ltd | Arts & recreation | 2009 |
| Cftr Estates Ltd | Real estate | 2025 |
| CFZ Natural History Ltd | Professional & scientific | 2010 |
| CG Surveys LLP | | 2019 |
| Chalice House | Education | 2012 |
| Chantal Law Fitness + Pilates LLP | | 2020 |
| Chapter Business Support Ltd | Administrative & support | 2023 |
| Charles Moase Property Management Ltd | Real estate | 2023 |
| Chef Duet Catering Co Ltd | Hospitality | 2021 |
| Chelmsford Pharma Services Ltd | Professional & scientific | 2023 |
| Chemica Labs Ltd | Information & communication | 2024 |
| Cheristow Farm Cottages Limited | Hospitality | 2012 |
| Cheverells Care Limited | Health & social care | 2012 |
| Chichester Arms Limited | Households | 2011 |
| Chocolate-Box Cottages Limited | Hospitality | 2025 |
| Chris Overson Property Ltd | Real estate | 2019 |
| Chris Symons & SON Ltd | Transport & logistics | 2003 |
| Chrissy Mouncey Design Ltd | Professional & scientific | 2015 |
| Ciento Gym Ltd | Arts & recreation | 2025 |
| CJC Building Services Ltd | Construction | 2024 |
| CJC Homes Ltd | Real estate | 2025 |
| CJN Construction Ltd | Construction | 2025 |
| CJS Interior Design Ltd | Administrative & support | 2016 |
| Cladco Holdings Limited | Financial services | 2023 |
| Claims for Injury Limited | Administrative & support | 2013 |
| Claire Marshall Design Limited | Professional & scientific | 2023 |
| Clearcut Campervan Design Ltd | Manufacturing | 2011 |
| Clearsky Developments Ltd | Construction | 2015 |
| Clearwater Brewery Ltd | Manufacturing | 2009 |
| Cleave Houses Treatment Plant Limited | Extraterritorial | 2002 |
| Cleveland Terrace (Freehold) Limited | Real estate | 2013 |
| Clinic for Holistic Medicine Ltd | Health & social care | 2016 |
| Clive Poole Consulting Ltd | Professional & scientific | 2010 |
| Clovelly Fish Limited | Wholesale & retail | 2025 |
| Clovelly Lakes LLP | | 2023 |
| CLS Auto Services Limited | Wholesale & retail | 2004 |
| CME Lodges Ltd | Hospitality | 2023 |
| CNC & Maintenance Services Ltd | Manufacturing | 2005 |
| Co Consulting (UK) Ltd | Administrative & support | 2011 |
| Co-Living Properties Limited | Construction | 2018 |
| Coach&H Commercial Ltd | Real estate | 2024 |
| Coach&H Ltd | Real estate | 2021 |
| Coach&H-Developments Ltd | Real estate | 2023 |
| Coastal Combat School Ltd | Education | 2026 |
| Coastal Holdings (South West) Ltd | Households | 2018 |
| Coastal Landscape Designs Ltd | Construction | 2023 |
| Cobbled Together Limited | Real estate | 2024 |
| Codecrafters Limited | Information & communication | 1992 |
| Coffee@Maggies CIC | Hospitality | 2024 |
| Cole and Cole Removals Ltd | Transport & logistics | 2021 |
| Colin Duwell Limited | Administrative & support | 2020 |
| Colome Clark Ltd | Wholesale & retail | 2023 |
| Comfort Camper Limited | Wholesale & retail | 2024 |
| Community CRE8TIVES C.I.C. | Arts & recreation | 2005 |
| Community GAS Partners Limited | Other services | 2025 |
| Compare Funerals Ltd | Other services | 2020 |
| Compassionate Devon CIC | Professional & scientific | 2025 |
| Complete Quality Care Limited | Other services | 2010 |
| Comportamento Limited | Professional & scientific | 2011 |
| Concept Living SW LLP | | 2025 |
| Conform Builds Ltd | Construction | 2023 |
| Connect Systems SW Limited | Construction | 2022 |
| Conservatory Roof Insulation and Replacement Specialists Ltd | Construction | 2025 |
| Constellar Advisory Ltd | Professional & scientific | 2025 |
| Continuing Healthcare Solutions Ltd | Administrative & support | 2015 |
| Cooper Consulting Business Development Ltd | Administrative & support | 2019 |
| Cooper Electrical-Fire-Security Ltd | Construction | 2021 |
| Coquet Cottages Limited | Administrative & support | 2017 |
| Corerobix Limited | Other services | 2016 |
| Cornwall Holiday Lets Ltd | Hospitality | 2021 |
| Cornwall Yacht Services Ltd | Manufacturing | 2022 |
| Corvus Osteo Ltd | Health & social care | 2009 |
| Cosmetic Motor Refinishing Limited | Wholesale & retail | 2024 |
| Costelloe Management Ltd | Professional & scientific | 2020 |
| Cosyhome Company (UK) Limited | Other services | 2017 |
| Cottage Maids Limited | Administrative & support | 2021 |
| Cottages in Northumberland Limited | Extraterritorial | 2007 |
| Coubus Management Limited | Households | 2014 |
| Country & Coastal Retreats Ltd | Hospitality | 2024 |
| Country Bidco Limited | Professional & scientific | 2018 |
| Country Midco 1 Limited | Financial services | 2018 |
| Country Midco 2 Limited | Extraterritorial | 2018 |
| Country Topco Limited | Extraterritorial | 2018 |
| Cows & Kisses Limited | Wholesale & retail | 2016 |
| CP SIX Commercial Limited | Real estate | 2024 |
| Craze Electrical Services Ltd | Construction | 2017 |