| Shade the UK CIC | Professional & scientific | 2020 |
| Shahi Spice Ltd | Hospitality | 2025 |
| Shakti Hardware Retail Ltd | Administrative & support | 2019 |
| Shallcrosse Safety Limited | Other services | 2024 |
| Shanti Estates Limited | Real estate | 2024 |
| Shard Data Solutions Ltd | Information & communication | 2024 |
| Sharp Fellas Barbers Ltd | Other services | 2025 |
| Shashikala Properties Ltd | Real estate | 2013 |
| Shehu Solution Ltd | Professional & scientific | 2023 |
| Shelby Group Ltd | Construction | 2026 |
| Shenker Haulage Limited | Transport & logistics | 2024 |
| Shepherd Building Solutions Ltd | Construction | 2016 |
| Shepherd Engineering Ltd | Professional & scientific | 2019 |
| Sheqeri Ltd | Professional & scientific | 2019 |
| Sherchan Financials Ltd | Information & communication | 2013 |
| Shergill Plastering Ltd | Construction | 2025 |
| Sherman Investments Limited | Real estate | 1995 |
| Sherwood Park Property (Kent) Ltd | Real estate | 2025 |
| Shield Contractors Ltd | Construction | 2019 |
| Shisali Homes Limited | Real estate | 2025 |
| Shivai Limited | Other services | 2015 |
| Short Sighted Cinema CIC | Information & communication | 2015 |
| Shreevik Investments Ltd. | Real estate | 2025 |
| Shri Guru Ravidass Cultural Limited | Construction | 2019 |
| Shtc Ltd | Financial services | 2024 |
| Shutter Pro Ltd | Wholesale & retail | 2023 |
| Siciliana Transporti Limited | Transport & logistics | 2019 |
| Sicuru Property Group Ltd | Real estate | 2023 |
| Sidcup Fascia & Soffit Limited | Construction | 2003 |
| Siddhi Yoga Limited | Health & social care | 2026 |
| Sidras Property Limited | Real estate | 2025 |
| SIG Risk Ltd | Professional & scientific | 2024 |
| Sigma Contracting Ltd | Construction | 2016 |
| Sigma Investors Ltd | Financial services | 2022 |
| Silvaback Solutions Limited | Information & communication | 2024 |
| Simionrgns Ltd | Health & social care | 2020 |
| Simmm Limited | Health & social care | 2022 |
| Simon C. Potts Limited | Financial services | 2003 |
| Simon Parrott Creative Ltd. | Professional & scientific | 2013 |
| Simply AMI Ltd | Administrative & support | 2019 |
| Simply Renting Limited | Real estate | 2024 |
| Simply Vape Bexley Ltd | Manufacturing | 2023 |
| Simplylife Limited | Real estate | 2025 |
| Simplypharmaco Ltd | Wholesale & retail | 2020 |
| Sina Contractors Ltd | Construction | 2020 |
| Sinai Healthcare Ltd | Health & social care | 2024 |
| Singh Homes Limited | Construction | 2020 |
| Sion T. Roberts Limited | Financial services | 2025 |
| Siosense Ltd | Professional & scientific | 2024 |
| Sirens & Sparkles First AID CIC | Health & social care | 2024 |
| Sirens Micropub Limited | Hospitality | 2026 |
| Sister Sparkles Ltd | Administrative & support | 2018 |
| Sisu Education & Consultancy Services Ltd | Financial services | 2015 |
| SJ Derm Studio Limited | Health & social care | 2026 |
| SJ Interiors Ltd | Construction | 2023 |
| SJP Electrics Ltd | Construction | 2024 |
| SJW Brickwork Limited | Construction | 2021 |
| SK Fire Safety Ltd | Public administration | 2023 |
| SK Partnership Tax Ltd | Professional & scientific | 2022 |
| SKA Fast Food Limited | Hospitality | 2015 |
| SKH Construction Ltd | Construction | 2023 |
| Skizz Ltd | Real estate | 2023 |
| SKR Gill Ltd | Arts & recreation | 2022 |
| Skyn Avenue Ltd | Other services | 2022 |
| Slifer Ltd | Real estate | 2020 |
| Slk-Services Limited | Construction | 2013 |
| Slme Limited | Real estate | 2021 |
| Smart PA Ltd | Administrative & support | 2020 |
| Smart Thinking Limited | Professional & scientific | 2015 |
| Smarte Revolution Ltd | Information & communication | 2021 |
| SMB Piping Solutions Limited | Professional & scientific | 2017 |
| SMC Property Investments Ltd | Real estate | 2021 |
| SNP Bexleyheath Ltd | Hospitality | 2026 |
| SO Noodle Ltd | Hospitality | 2024 |
| Soares Properties Ltd. | Real estate | 2019 |
| Sohni Travel Limited | Administrative & support | 2000 |
| Soho Transport Ltd | Transport & logistics | 2026 |
| Soken & US Ltd | Health & social care | 2026 |
| Solanto Ltd | Information & communication | 2025 |
| Solomon Consults Ltd | Health & social care | 2025 |
| Somerville Pearce Fine Art Limited | Wholesale & retail | 2025 |
| Somnus Curare Ltd | Health & social care | 2025 |
| Sonexus Limited | Professional & scientific | 2026 |
| Sooky Holdings Limited | Financial services | 2022 |
| Sooky Media Limited | Professional & scientific | 2023 |
| Sophie's Beauty Lounge Limited | Other services | 2024 |
| Sorb Electrics Ltd | Construction | 2018 |
| SOS Buildings UK Limited | Construction | 2017 |
| SOS Pharma Limited | Wholesale & retail | 2025 |
| SOSE&SONS96 Limited | Wholesale & retail | 2025 |
| South East Home Improvements Ltd | Construction | 2025 |
| South East Nosh Service Ltd | Wholesale & retail | 2025 |
| South Street Romford (Block a) Management Company Limited | Professional & scientific | 1989 |
| South Street Romford (Block B) Management Company Limited | Professional & scientific | 1989 |
| Southend Anchor Limited | Transport & logistics | 2021 |
| Southend Assets Group Ltd | Real estate | 2020 |
| Southend Assets Hartington Ltd | Real estate | 2019 |
| Spaceup Build Ltd | Construction | 2026 |
| Spade.Fit Limited | Information & communication | 2024 |
| Sparkup Business Solutions Ltd | Professional & scientific | 2023 |