| Potential Space C.I.C. | Hospitality | 2024 |
| Potts Building and Shopfitting Limited | Construction | 2014 |
| Potts Construction Ltd | Construction | 2019 |
| Powerful Ideas Ltd | Professional & scientific | 2019 |
| Praan (Belper) Ltd | Hospitality | 2024 |
| Praan (Derby) Ltd | Hospitality | 2026 |
| Practical Organisation Solutions Limited | Professional & scientific | 2015 |
| Prescribing and Therapeutics Training Ltd | Education | 2019 |
| Prestige Beauty Clinic Limited | Other services | 2015 |
| Pretties&Sparklies Ltd | Extraterritorial | 2024 |
| Pretty Easy Limited | Professional & scientific | 2020 |
| Primary Property Horizons Limited | Administrative & support | 2009 |
| Prime Flooring Solutions Ltd | Construction | 2018 |
| Prism Hygiene Limited | Wholesale & retail | 2010 |
| Prism Laser Clinics Ltd | Other services | 2024 |
| Pro Build Investments Ltd | Construction | 2025 |
| Pro-Tecmidlands Ltd | Construction | 2010 |
| Procurex Limited | Professional & scientific | 2007 |
| Procys Limited | Professional & scientific | 2023 |
| Profile Barber Studio Limited | Other services | 2022 |
| Profile Hair Replacement Limited | Other services | 2023 |
| Project Brief Limited | Information & communication | 2019 |
| Project Clothing UK Ltd | Wholesale & retail | 2019 |
| Projects Support Ltd | Professional & scientific | 2026 |
| Prompt Training Ltd | Education | 2010 |
| Properly Maintained Limited | Construction | 2012 |
| Protective Polymers Limited | Manufacturing | 2015 |
| Protective Properties Ltd | Real estate | 2023 |
| Protective Sealants Limited | Manufacturing | 2018 |
| Provenance Productions Limited | Arts & recreation | 2018 |
| Proxisphere Ltd | Information & communication | 2024 |
| PRS Bathrooms Limited | Construction | 2013 |
| PS Metallurgical Services Ltd | Professional & scientific | 2014 |
| Pump Stations Direct Ltd | Wholesale & retail | 2017 |
| Purple Velocity Ltd | Professional & scientific | 2013 |
| PW Site Engineering Ltd | Construction | 2016 |
| QB Building Solutions Ltd. | Construction | 2022 |
| QR4RIGS Ltd | Manufacturing | 2024 |
| QRF Timber Products Limited | Wholesale & retail | 2024 |
| Qrisk Consultants Ltd | Financial services | 2009 |
| Quadamill Limited | Wholesale & retail | 1972 |
| Quality Building Services Limited | Professional & scientific | 1983 |
| Quancho Limited | Construction | 2018 |
| QUE Sera Productions Ltd | Arts & recreation | 2013 |
| Quiescis Limited | Information & communication | 2018 |
| R & L Developments (Derbyshire) Limited | Construction | 2023 |
| R & SC Financial Limited | Financial services | 2017 |
| R & T Electrics Limited | Construction | 2003 |
| R J Glanville Limited | Wholesale & retail | 2009 |
| R Stephenson Developments Ltd | Construction | 2024 |
| Racc Engineering Solutions Limited | Professional & scientific | 2013 |
| Rail PR Limited | Professional & scientific | 2004 |
| Rainier Hotels and Hospitality Ltd | Hospitality | 2025 |
| Raisor Limited | Professional & scientific | 2014 |
| Ralls Consulting Ltd | Professional & scientific | 2012 |
| Randlepike Events Ltd | Hospitality | 2026 |
| RAW Solutions Limited | Manufacturing | 2016 |
| Raynor Electrical Services Ltd | Construction | 2011 |
| Realise My Child's Potential LLP | | 2016 |
| Realizeuk Ltd | Construction | 2022 |
| REB Solutions Ltd | Professional & scientific | 2007 |
| Rebound Retail Limited | Wholesale & retail | 2013 |
| Record Trax Limited | Wholesale & retail | 1995 |
| Redfox Beauty Limited | Other services | 2025 |
| Redsans Limited | Professional & scientific | 2015 |
| Redtree Limited | Manufacturing | 1996 |
| Redwing Group Ltd | Information & communication | 2015 |
| Rees Property Investments Limited | Real estate | 2016 |
| Refined PUB Group Ltd | Hospitality | 2024 |
| Refurbuk Limited | Construction | 2013 |
| Regency Futures Limited | Financial services | 2015 |
| Reginald Street Electrics Limited | Wholesale & retail | 1983 |
| REL GAS Limited | Construction | 2003 |
| Resolv Engineering Ltd | Professional & scientific | 2023 |
| Reuben's Estates & Escapes Ltd | Real estate | 2023 |
| Reubicon Supplies Ltd | Wholesale & retail | 2024 |
| Reunion Deli Ltd | Hospitality | 2016 |
| Reyviation Limited | Construction | 2015 |
| RG Construction Materials Ltd | Professional & scientific | 2024 |
| RHJ2 Limited | Professional & scientific | 2006 |
| Richard Cant Psychology Ltd | Health & social care | 2022 |
| Richard Hall Architectural Surveyor Ltd | Professional & scientific | 2015 |
| Richard Lester Limited | Extraterritorial | 2019 |
| Richard Lester Properties Limited | Real estate | 2012 |
| Richard Lester Transport Limited | Transport & logistics | 2010 |
| Ride 4 Hire Limited | Arts & recreation | 2013 |
| Ridgeway Farm Court Management Company Limited | Households | 1998 |
| RIO Racing Limited | Arts & recreation | 2025 |
| Ripley Building Limited | Wholesale & retail | 2024 |
| Ripley Building Plastics Ltd | Construction | 2011 |
| Ripley Electrical Services Limited | Construction | 2014 |
| Risk & Safety Management Services Limited | Administrative & support | 1997 |
| Riverside Equestrian Limited | Extraterritorial | 2020 |
| RJ Joinery & Building Ltd | Construction | 2024 |
| RJG Farming Limited | Agriculture & fishing | 2018 |
| RJH Construction Ltd. | Construction | 2001 |
| RJT Geotechnical Ltd | Construction | 2026 |
| RM Innovations and Leadership Limited | Other services | 2017 |
| RMB Contractors Limited | Construction | 1974 |
| RNL Logistics Services Limited | Professional & scientific | 2014 |