| ENT Associates Ltd | Health & social care | 2017 |
| ENT Opinions Ltd | Health & social care | 2011 |
| ENT Solutions Ltd | Health & social care | 2013 |
| Enter YES Ltd. | Information & communication | 2015 |
| Enterprise Equity II LP | | 2007 |
| Enterprise Equity II Managers LP | | 2007 |
| Enterprise Holding Group Ltd | Financial services | 2026 |
| Enterprise Investment Holdings Ltd | Real estate | 2024 |
| Enterprise Marketing (UK) Limited | Professional & scientific | 2014 |
| Enterprise NI Contracts Ltd | Construction | 2019 |
| Entertainment Events Organisation Limited | Arts & recreation | 2019 |
| Entity Promotions Ltd | Hospitality | 2024 |
| Entomol Limited | Administrative & support | 2013 |
| Entryview Limited | Real estate | 2026 |
| Enubilous Limited | Information & communication | 2024 |
| ENV Decorators Limited | Other services | 2015 |
| Environmental Contract Cleaners Limited | Administrative & support | 2008 |
| Environmental Damage Management Limited | Water & waste | 2010 |
| Environmental Justice Network Ireland Ltd | Professional & scientific | 2021 |
| Environmental Street Furniture Ltd. | Wholesale & retail | 2012 |
| Envisage Future Energy (UK & Ireland) Limited | Energy | 2024 |
| Envision Management Consultants Ltd | Professional & scientific | 1998 |
| Enzai Technologies Limited | Information & communication | 2021 |
| EOA Holdings Limited | Financial services | 2018 |
| Eoghan RUA Ireland NO.249 Limited | Extraterritorial | 2024 |
| Eohmedia Ltd | Manufacturing | 2025 |
| Eolas Design Limited | Professional & scientific | 2024 |
| Eolas Educational Services Limited | Education | 2010 |
| Eolas Medical Ltd | Information & communication | 2019 |
| EON Clothing NI Ltd | Wholesale & retail | 2024 |
| Eontm Ltd | Information & communication | 2025 |
| Eori (NI) Limited | Transport & logistics | 2020 |
| EOS Systems Unlimited | Information & communication | 2002 |
| EP Contracts (N.I.) Limited | Real estate | 2017 |
| EP Media Investments Limited | Financial services | 2025 |
| Epathchina Limited | Wholesale & retail | 2025 |
| EPC Belfast Ltd | Administrative & support | 2007 |
| Epcam Ltd | Information & communication | 2025 |
| Epic Creations Group Ltd | Manufacturing | 2026 |
| Epic E-Store Ltd | Wholesale & retail | 2025 |
| Epic Journal Ltd | Information & communication | 2026 |
| Epic Recruitment Limited | Administrative & support | 2004 |
| Epicure Select Foods Limited | Wholesale & retail | 1999 |
| EPJ Associates Northern Ireland Limited | Wholesale & retail | 2021 |
| Epoxy Flooring Systems Ltd | Construction | 2024 |
| EPR Accounting Services Ltd | Professional & scientific | 2018 |
| Epworth 1959 Limited | Extraterritorial | 2013 |
| EQD Travel Ltd | Administrative & support | 2010 |
| EQM Overseas L.P. | | 2018 |
| Equaan Limited | Financial services | 2025 |
| Equiclean Mats Ltd | Manufacturing | 2025 |
| Equilibrant Contracts Limited | Professional & scientific | 2021 |
| Equilibrant Ltd | Professional & scientific | 2009 |
| Equilibrium Business Services Limited | Professional & scientific | 2018 |
| Equinox Wills and Trusts Ltd | Financial services | 2015 |
| Equip Fitness Ltd | Arts & recreation | 2017 |
| Equipment Bazaar Limited | Other services | 2017 |
| Equipment Bazaar Warehouse Limited | Wholesale & retail | 2023 |
| Equipment Management Solutions (UK) Limited | Wholesale & retail | 2004 |
| Equipment Management Solutions Group Limited | Wholesale & retail | 2024 |
| Equipmentshare UK Limited | Information & communication | 2022 |
| Equipping for Life Ltd. | Education | 2018 |
| Equitas App Ltd. | Information & communication | 2016 |
| Equity Return Ltd | Administrative & support | 2012 |
| Equivantage Animal Health Ltd | Wholesale & retail | 2026 |
| Equmulus Ltd | Real estate | 2020 |
| ERA Counselling CIC | Health & social care | 2026 |
| ERA Events Limited | Other services | 2024 |
| ERA Luxury Travel Ltd | Administrative & support | 2025 |
| Eradication Ltd | Construction | 2024 |
| Erdis Limited | Professional & scientific | 2013 |
| Eremon Eco Ltd | Wholesale & retail | 2025 |
| Erga Strategies Limited | Professional & scientific | 2009 |
| Erganagh Construction Services Ltd | Construction | 2013 |
| Ergea Belfast Limited | Health & social care | 2001 |
| Eric Connor Ltd | Wholesale & retail | 2025 |
| Erica Starling Productions Ltd | Information & communication | 2010 |
| Erica Starling SPV2 Ltd | Information & communication | 2021 |
| Erimus Properties Ltd | Real estate | 2019 |
| Erjun Limited | Wholesale & retail | 2024 |
| Erne Lough Properties NO.1 Limited | Real estate | 2021 |
| Erne Lough Properties NO.2 Limited | Real estate | 2021 |
| Erneside Furniture Ltd | Wholesale & retail | 2018 |
| ERO Contractor Limited | Administrative & support | 2022 |
| Erobin Consultancy Ltd | Other services | 2023 |
| Errigal Accountants Ltd | Professional & scientific | 2023 |
| Errigal BIO Limited | Professional & scientific | 2025 |
| Errigal Construction (IRL) Ltd | Construction | 2023 |
| Errigal Energy Limited | Energy | 2012 |
| Errigal Investment Properties Ltd | Real estate | 2025 |
| Errigal Property Group Ltd | Real estate | 2025 |
| ERS Vapes Ltd | Wholesale & retail | 2026 |
| ESC Construction Consultants Limited | Professional & scientific | 2019 |
| ESC Films Ltd | Arts & recreation | 1999 |
| Escapade HQ Ltd | Arts & recreation | 2018 |
| Escarmouche Action Park Ltd | Arts & recreation | 2019 |
| Escarmouche Activities Ltd | Arts & recreation | 2023 |
| Eshmore Ltd | Construction | 2006 |
| Eshwary Developments Limited | Construction | 2000 |
| Esic Consultancy Ltd. | Information & communication | 2022 |