| Emmet O'Neill Limited | Financial services | 2020 |
| Emmie Louise Limited | Wholesale & retail | 2024 |
| Emni Ltd | Professional & scientific | 2026 |
| Empatheyes Ltd | Professional & scientific | 2020 |
| Empire Competitions Ltd | Information & communication | 2024 |
| Empire Products Limited | Wholesale & retail | 2025 |
| Empirical Recruitment Ltd | Administrative & support | 2025 |
| Employee Advocate Limited | Professional & scientific | 2026 |
| Employee Ownership Ireland Limited | Other services | 2024 |
| Empm Consulting Ltd | Information & communication | 2016 |
| Emporia Corp Limited | Wholesale & retail | 2023 |
| Empower Renewables Management Limited | Energy | 2023 |
| Empower Yibin Ltd | Wholesale & retail | 2024 |
| Empowered Belfast Ltd | Arts & recreation | 2025 |
| Empowered Freedom Limited | Information & communication | 2023 |
| Empowerment Consulting Ltd | Health & social care | 2018 |
| Empowerthem NI CIC | Education | 2024 |
| Emre Kaya Limited | Wholesale & retail | 2024 |
| Emrethinq Ltd | Information & communication | 2023 |
| Emrobapa Belfast Ltd | Hospitality | 2019 |
| EMS (NI) Limited | Real estate | 2008 |
| EMV Transport N.I. Ltd | Transport & logistics | 2026 |
| Emvo Bay Limited | Wholesale & retail | 2025 |
| EN Trading Ltd | Wholesale & retail | 2022 |
| En-Act Music Ltd | Education | 2015 |
| En-Vent Ltd | Construction | 2021 |
| Enable Together Limited | Health & social care | 2025 |
| Enagh Productions Limited | Information & communication | 2021 |
| Encom Energy Ltd | Construction | 2021 |
| Encycle Studios Ltd | Information & communication | 2014 |
| Enddover Ltd | Wholesale & retail | 2025 |
| Endeavour Group Holdings Ltd | Financial services | 2015 |
| Endeavour Interactions Belfast Ltd | Administrative & support | 2019 |
| Endeavour JMC Limited | Financial services | 2026 |
| Endeavour One Limited | Real estate | 2012 |
| Endeavour Security Trustee Limited | Administrative & support | 2013 |
| Endless Music Limited | Hospitality | 2007 |
| Endon Properties Limited | Construction | 2000 |
| Endow International Trading Hongkong Limited | Wholesale & retail | 2024 |
| Endurable Performance Ltd | Information & communication | 2025 |
| Endzone Investments Limited | Financial services | 2020 |
| Enerco Energy NI Limited | Other services | 2024 |
| Enercon Wind Energy NI Limited | Construction | 2020 |
| Enercon Windfarm Service NI Limited | Administrative & support | 2019 |
| Energia Capital Limited | Financial services | 1997 |
| Energia Customer Solutions NI Limited | Energy | 1999 |
| Energia Group NI Financeco PLC | Financial services | 2017 |
| Energia Group NI Holdings Limited | Professional & scientific | 1997 |
| Energia Hydrogen Limited | Energy | 2019 |
| Energia NI Holdco Limited | Financial services | 1997 |
| Energia NI Storage Limited | Financial services | 2016 |
| Energia Properties Limited | Real estate | 1997 |
| Energia Renewables Company 1 Limited | Financial services | 2011 |
| Energia Renewables Company 2 Limited | Financial services | 2015 |
| Energia Renewables Company 3 Limited | Financial services | 2015 |
| Energia Renewables Company 4 Limited | Financial services | 2017 |
| Energis (Ireland) Limited | Information & communication | 1999 |
| Energis Recruitment Ltd. | Administrative & support | 2012 |
| Energise Sales Ltd | Professional & scientific | 2020 |
| Energized Online Limited | Other services | 2022 |
| Energy Media Group Limited | Information & communication | 2024 |
| Energy Saving Initiatives C.I.C. | Other services | 2018 |
| Energy Solutions (Ireland) Limited | Other services | 2017 |
| Energy Storage Consultants Limited | Information & communication | 2021 |
| Energy Surveys NI Ltd | Professional & scientific | 2025 |
| Energy Trading International Ltd | Energy | 2019 |
| Energy Trading Ireland Limited | Energy | 2012 |
| ENERGY4AUTISM Ltd | Energy | 2018 |
| Energystream Ltd | Professional & scientific | 2025 |
| Energywise Services Ltd | Professional & scientific | 2024 |
| Enexis (Distribution) Ltd | Construction | 2019 |
| Engage With AGE | Health & social care | 2000 |
| Engine & Truck (N.I.) Limited | Wholesale & retail | 2002 |
| Engine Clean Solutions Ltd | Wholesale & retail | 2014 |
| Engineering Asset Maintenance Solutions Limited | Information & communication | 2013 |
| Engineering Equipment Company (Northern Ireland) Limited | Wholesale & retail | 1975 |
| Engineering Plus Ltd | Construction | 2025 |
| Engineering Services (NI) Limited | Professional & scientific | 2014 |
| Enginius Ltd | Information & communication | 2018 |
| Enginova Ltd | Professional & scientific | 2024 |
| Enhance ALL Marketing Trading Ltd | Wholesale & retail | 2025 |
| Enhance Beauty & Aesthetics Salon Ltd | Other services | 2026 |
| Enhance Training Academy Ltd | Other services | 2026 |
| Enhanced Aesth. Ltd | Health & social care | 2021 |
| Enhanced Engineering Services Ltd | Manufacturing | 2024 |
| Enhanz Ltd | Professional & scientific | 2022 |
| Enibeauty Style Ltd | Wholesale & retail | 2024 |
| Enigma Plus Ltd | Information & communication | 2014 |
| Enigma Syed Ltd | Wholesale & retail | 2025 |
| Enigmanity Limited | Manufacturing | 2024 |
| Enjoyclub Ltd | Other services | 2022 |
| Enlanders (Jewellers) Limited | Other services | 1950 |
| Enler Holdings Ltd. | Professional & scientific | 2018 |
| Enler Ltd | Professional & scientific | 2022 |
| Enler Village Management Company Limited | Real estate | 2023 |
| Enlerbank Apartments Management Company Limited | Households | 2023 |
| Enlerstone Consulting Ltd | Professional & scientific | 2025 |
| Enny Solutions Ltd | Professional & scientific | 2025 |
| Enough Dynamite Productions Limited | Information & communication | 2010 |
| Enqvist Consulting Ltd | Wholesale & retail | 2025 |