| SOS Design Consultancy Limited | Professional & scientific | 2006 |
| SOS Productions Limited | Information & communication | 2021 |
| Sosteria Ltd | Hospitality | 2014 |
| Sotto Sotto Ltd | Hospitality | 2011 |
| Soul Media Ltd | Professional & scientific | 2018 |
| Sound Church Ltd | Other services | 1998 |
| Sound Ideas Marketing Ltd | Professional & scientific | 2021 |
| Soundlight Industries Limited | | 1986 |
| Sounds Good Productions Ltd | Arts & recreation | 2024 |
| Source Antiques Limited | Wholesale & retail | 2009 |
| Source Marketing and Retail Design Ltd | Information & communication | 2019 |
| Soursop Limited | Information & communication | 2020 |
| South Gloucestershire Rentals Limited | Real estate | 2023 |
| South Street Bakehouse Ltd | Wholesale & retail | 2025 |
| South West Auto Storage Ltd. | Transport & logistics | 2013 |
| South West Barbers Ltd | Other services | 2022 |
| South West Building & Refurbishments Ltd | Construction | 2021 |
| South West Heating Limited | Construction | 2000 |
| South West Registrars Limited | Extraterritorial | 1990 |
| South West School of Plastering Limited | Wholesale & retail | 2004 |
| South West Specialist Surgery Ltd | Health & social care | 2022 |
| South West Whole Foods Limited | Manufacturing | 2023 |
| Southall Web IT Ltd | Information & communication | 2022 |
| Southam Healthcare Ltd | Health & social care | 2020 |
| Southdown Accountancy Services Limited | Professional & scientific | 2006 |
| Southdown Fish Bar Ltd | Hospitality | 2019 |
| Southern Cross Developments Ltd | Real estate | 2025 |
| Southernford Associates Limited | Hospitality | 1982 |
| Southernhay Media Limited | Professional & scientific | 2000 |
| Southsands Capital Ltd | Financial services | 2024 |
| Southside Family Project | Health & social care | 1997 |
| Southwest Landscape Construction Ltd | Administrative & support | 2024 |
| Southwest Music Promotions Limited | Arts & recreation | 2004 |
| Southwest Signings Limited | Professional & scientific | 2012 |
| Southwest Sports and Fitness Ltd | Arts & recreation | 2025 |
| Southwinds 1967 Limited | Extraterritorial | 2014 |
| Sova Surveys Limited | Construction | 2016 |
| SP11 LLP | | 2018 |
| Spa Plating Ltd | Manufacturing | 2006 |
| Spa Stays Limited | Hospitality | 2024 |
| Space Health & Fitness Limited | Arts & recreation | 2009 |
| Space Station Hotel Group Limited | Hospitality | 2018 |
| Space to Belong Ltd | Professional & scientific | 2025 |
| Spaceintime Records Limited | Information & communication | 2023 |
| Spacerevolution Limited | Professional & scientific | 2016 |
| Spaces in Between Limited | Other services | 2019 |
| SPAD3 Ltd | Water & waste | 2025 |
| Spalding Consulting Ltd | Professional & scientific | 2019 |
| Spanish Obsessed Ltd | Education | 2017 |
| Spark Layer Limited | Information & communication | 2020 |
| Sparkling Matters Ltd | Extraterritorial | 2016 |
| Sparkloop Limited | Professional & scientific | 2008 |
| Sparks Electrical Contracting Ltd | Construction | 2017 |
| Sparkwave Ltd | Professional & scientific | 2021 |
| Spartans Basketball Academy Limited | Arts & recreation | 2019 |
| Speakezee Holdings Limited | Information & communication | 2015 |
| Specialist Glazing Projects Limited | Construction | 2016 |
| Spectromatch Limited | Information & communication | 2004 |
| Spectrum Properties Solution Ltd | Households | 2021 |
| Speedy Access Ltd | Construction | 2021 |
| Speedy Link Logistics Limited | Transport & logistics | 2023 |
| Speedywash Limited | Other services | 2004 |
| Speen Property Trust Limited | Real estate | 1946 |
| Spencer Partners Corporate Finance Limited | Administrative & support | 2001 |
| Spherecost Ltd | Professional & scientific | 2021 |
| Spherical Expressions Limited | Real estate | 2012 |
| Spicer & Mccabe Ltd | Hospitality | 2015 |
| Spiller & Powell Enterprises Limited | Information & communication | 2001 |
| Spin-Office Limited | Wholesale & retail | 2014 |
| Spire Electrical Services Limited | Construction | 2013 |
| Spirit Photographic Limited | Arts & recreation | 2013 |
| Spitfire Publishers Ltd | Information & communication | 2018 |
| Splasherist Bath Ltd | Wholesale & retail | 2025 |
| Splasherist Limited | Real estate | 2023 |
| Splinters INT Ltd | Manufacturing | 2009 |
| Splitpoint Solutions Ltd | Information & communication | 2024 |
| Sponsable Ltd | Information & communication | 2025 |
| Sport Bath Ltd | Arts & recreation | 2017 |
| Sport Insights Media Ltd | Information & communication | 2020 |
| Sport Instructors Ltd | Education | 2022 |
| Sports Holdings Limited | Arts & recreation | 2019 |
| Spotdev Services Ltd | Information & communication | 2022 |
| Spray TEC (Bath) Ltd | Wholesale & retail | 2014 |
| Sprayline Limited | Wholesale & retail | 2019 |
| Spring Equinox Capital Limited | Professional & scientific | 2021 |
| Spring Tourism Limited | Administrative & support | 2026 |
| Springfield Family Investment Company | Financial services | 2018 |
| SPS Commercial Solutions Limited | Construction | 2020 |
| SPS Plumbing & Heating (SW) Limited | Construction | 2012 |
| Spud GUN Studios Limited | Information & communication | 2025 |
| Square Grill Restaurant Piano Bar Ltd | Hospitality | 2021 |
| Squarebath Ltd | Wholesale & retail | 2013 |
| Squeaky G Limited | Wholesale & retail | 2015 |
| Squidly Ltd | Professional & scientific | 2008 |
| SR Architects Limited | Professional & scientific | 2003 |
| SRA Architects Group LLP | | 2014 |
| SRA Architects Ltd | Professional & scientific | 2022 |
| Sri-Licious Limited | Hospitality | 2014 |
| SRJ Carpentry Limited | Construction | 2022 |
| SRT Marine System Solutions Limited | Professional & scientific | 2009 |