| Sleepy DOE Ltd | Professional & scientific | 2012 |
| Sleight Side Property Limited | Real estate | 2024 |
| Sliva Flat Ltd | Hospitality | 2020 |
| SLL Property Group Ltd | Financial services | 2025 |
| Slouchy and Sleep Ltd | Wholesale & retail | 2020 |
| Slowcat Ltd | Administrative & support | 2005 |
| SLP Media Ltd | Information & communication | 2023 |
| Slug Rings Limited | Manufacturing | 2005 |
| Slumber Luxe Limited | Wholesale & retail | 2024 |
| Smart & Wylde Ltd | Hospitality | 2024 |
| Smart and Fresh Cleaning Services Ltd | Administrative & support | 2025 |
| Smart Brush UK Ltd | Other services | 2026 |
| Smart Design and Build (SW) Ltd | Construction | 2025 |
| Smart FOX Capital Limited | Real estate | 2020 |
| Smart Joy Limited | Real estate | 2017 |
| Smart Solutions Building Services Limited | Construction | 2015 |
| Smart-Tab Products Limited | Manufacturing | 2005 |
| Smartarch Ltd | Professional & scientific | 2011 |
| Smartiepads Ltd | Hospitality | 2015 |
| Smdm Ltd | Hospitality | 2022 |
| Smdr Limited | Professional & scientific | 2020 |
| SME FD Limited | Professional & scientific | 2018 |
| Smed Holdings Limited | Real estate | 2017 |
| SMH (Bath) Limited | Professional & scientific | 2005 |
| SMH Taxation and Accountancy Ltd | Professional & scientific | 2023 |
| SMH Verification Ltd | Professional & scientific | 2025 |
| Smile Care 82 Limited | Health & social care | 2026 |
| SMILE32 Limited | Health & social care | 2006 |
| Smiths & Packer Property Group Ltd Ltd | Real estate | 2024 |
| SMJ Trustees Limited | Administrative & support | 2020 |
| Smoochsuits Ltd | Wholesale & retail | 2020 |
| Smooth Travel Limited | Other services | 2023 |
| Smora Limited | Administrative & support | 2025 |
| SMS Medics Ltd | Health & social care | 2016 |
| Snapshot Game Ltd | Agriculture & fishing | 2015 |
| Sniper Media Ltd | Wholesale & retail | 2025 |
| Snkr Supplies Ltd | Administrative & support | 2019 |
| Snodland Limited | Financial services | 2016 |
| Snoppits Property Agency LLP | | 2024 |
| Snow and Sand Limited | Hospitality | 2020 |
| Snowdrop Solutions Ltd | Information & communication | 2013 |
| Snowhill Estates Limited | Professional & scientific | 2015 |
| SNS Advisory Limited | Professional & scientific | 2021 |
| Snug Studio Ltd | Professional & scientific | 2025 |
| SO a Stays Limited | Real estate | 2022 |
| SO Maps Limited | Information & communication | 2014 |
| Society Bars (Birmingham) Ltd | Hospitality | 2024 |
| Society Foodhall & Bars Holdings Ltd | Financial services | 2021 |
| Society Foodhalls (Birmingham) Ltd | Hospitality | 2022 |
| Society Foodhalls (Manchester) Ltd | Construction | 2019 |
| Socket MAN Limited | Construction | 2014 |
| Sofa Barakah Ltd | Health & social care | 2024 |
| Sofia Capital Limited Partnership | | 2013 |
| Softdealz Ltd | Wholesale & retail | 2025 |
| Softmill Ltd | Professional & scientific | 2025 |
| Softtronics Ltd | Information & communication | 2010 |
| Sois AI Ltd | Professional & scientific | 2026 |
| Solace Power (UK) Limited | Professional & scientific | 2023 |
| Solano Consulting LLP | | 2012 |
| Solar Canopy Limited | Professional & scientific | 2023 |
| Solar Park Limited | Professional & scientific | 2023 |
| Solar PPA Limited | Professional & scientific | 2020 |
| Soldi CDM and Fire Limited | Public administration | 2025 |
| Soldi Developments Limited | Construction | 2025 |
| Soldi Group Ltd | Financial services | 2018 |
| Solicitors Own Software Limited | Information & communication | 1987 |
| Solicitous Limited | Extraterritorial | 2018 |
| Solis Holdings Ltd | Real estate | 2019 |
| Solon Advisory Limited | Information & communication | 2020 |
| Solsbury and SIX Limited | Information & communication | 2024 |
| Solsbury Tax Consulting Ltd | Professional & scientific | 2019 |
| Solsbury View Ltd | Financial services | 2017 |
| Solsburys Limited | Extraterritorial | 1996 |
| Solstice Equestrian Projects Limited | Construction | 2017 |
| Solution Simulations Ltd. | Information & communication | 1998 |
| Solutions Inside Limited | Education | 2022 |
| Solutions Republic Ltd | Professional & scientific | 2005 |
| Som-C Ltd | Information & communication | 2025 |
| Soma Women’S Health Ltd | Health & social care | 2023 |
| Somalab Ltd | Health & social care | 2024 |
| Some Ducks Ltd | Manufacturing | 2022 |
| Somer Joinery Limited | Manufacturing | 2000 |
| Somerset & Dorset Railway Heritage Trust | Arts & recreation | 1995 |
| Somerset House (Bath) Management Company Limited | Households | 2016 |
| Somerset House Investments Limited Partnership | | 1988 |
| Somerset Merch Ltd | Wholesale & retail | 2025 |
| Somerset Sheds Limited | Manufacturing | 2026 |
| Somerset Swim Babies Limited | Arts & recreation | 2016 |
| Somersetshire Coal Canal Company LLP | | 2016 |
| Somnus Scientific Limited | Manufacturing | 2018 |
| Somnus Stays Ltd | Real estate | 2024 |
| SON of a BUN Ltd | Hospitality | 2023 |
| Sonder Property Group Ltd | Real estate | 2025 |
| Sonistics Ltd | Administrative & support | 2005 |
| Sooothe Ltd | Professional & scientific | 2016 |
| Sophem Limited | Professional & scientific | 2011 |
| Sophia Studios Ltd | Professional & scientific | 2025 |
| Sophie Harding Medical Ltd | Health & social care | 2023 |
| Soranek Limited | Real estate | 1989 |
| Sorbet Topco Limited | Manufacturing | 2023 |