| Structronix (Inspections) Ltd | Professional & scientific | 2024 |
| Structronix Ltd | Professional & scientific | 2023 |
| Structural Simplicity Ltd | Professional & scientific | 2020 |
| Strudwicks Limited | Mining & quarrying | 2006 |
| Studio 12 Music Ltd | Arts & recreation | 2013 |
| Studio 41 Fitness Ltd | Arts & recreation | 2012 |
| Studio 51 Tattoos Ltd | Other services | 2017 |
| STUDIOONE9@UK Ltd | Professional & scientific | 2024 |
| Stwff Ltd | Manufacturing | 2026 |
| Stylebible Limited | Information & communication | 2004 |
| Styledeluxe Limited | Professional & scientific | 1994 |
| Suave Television Ltd | Information & communication | 2023 |
| Sublime Hospitality Ltd | Hospitality | 2025 |
| Suhaan Heating and Plumbing Ltd | Construction | 2023 |
| Suits and Ties Ltd | Wholesale & retail | 2023 |
| Sukiblofeld Ltd | Hospitality | 2025 |
| Sula Café and Pizzeria Ltd | Hospitality | 2021 |
| Sumillion Limited | Information & communication | 2012 |
| Sumitomo (SHI) Cryogenics of Europe Limited | Wholesale & retail | 1983 |
| Summer Lane Management Company Limited | Households | 2021 |
| Summit Pharma Limited | Wholesale & retail | 2024 |
| Sumner Data Services Limited | Information & communication | 2019 |
| Sumnima Trading Ltd | Wholesale & retail | 2023 |
| Sumo Enterprises Limited | Education | 2016 |
| Sun Infotech Ltd | Information & communication | 2018 |
| Sunergy Group Ltd | Construction | 2022 |
| Sunlight Consultancy Limited | Information & communication | 2014 |
| Sunlight Services Limited | Professional & scientific | 1989 |
| Sunny Info Ltd | Information & communication | 2010 |
| Sunny Realtors Ltd | Real estate | 2026 |
| Sunnyside Services Limited | Health & social care | 2015 |
| Sunrise Safeguarding Solutions Ltd | Public administration | 2023 |
| Sunuk Megastore Ltd | Wholesale & retail | 2020 |
| Super 15 Associates Ltd | Information & communication | 2014 |
| Super Go Team Ltd | Information & communication | 2018 |
| Supporsys Ltd | Information & communication | 2005 |
| Supported Living Enablement Services Ltd | Health & social care | 2023 |
| Suppria Limited | Real estate | 2022 |
| Supra Ultra Ltd | Construction | 2021 |
| Supremo Consultancy Services Limited | Information & communication | 2016 |
| Suregrip Tyres Limited | Wholesale & retail | 2010 |
| Suresource Ltd | Information & communication | 2015 |
| Surf Yoga Happiness Ltd | Wholesale & retail | 2018 |
| Surguru Ltd | Hospitality | 2020 |
| Surrey Care Consultancy Ltd | Professional & scientific | 2021 |
| Survey & Laser Centre Ltd | Other services | 2019 |
| Susanna Waern Psychology Ltd | Health & social care | 2017 |
| Susaso Limited | Real estate | 2023 |
| Susco Building Services Ltd | Extraterritorial | 2024 |
| Sustainable Pest Solutions Limited | Administrative & support | 2024 |
| SV5 Ltd | Real estate | 2021 |
| Svas Pharma QR Ltd. | Professional & scientific | 2017 |
| Svnna Limited | Real estate | 2024 |
| Svsa Consultancy Services Ltd | Information & communication | 2017 |
| Swaeltjies Limited | Other services | 2015 |
| Swag Pack Ltd | Manufacturing | 2020 |
| Swallowfield Services Limited | Information & communication | 1998 |
| Swan Electronics Manufacturing Solutions Ltd | Manufacturing | 2007 |
| Swan Therapeutic Services Ltd | Administrative & support | 2016 |
| Swarco UK & Ireland Ltd | Manufacturing | 1980 |
| Swdc Holdings Ltd | Financial services | 2025 |
| Sweet Sista Limited | Wholesale & retail | 2022 |
| Sweetmile Limited | Education | 2018 |
| Swiftglide Ltd | Arts & recreation | 2023 |
| Swingate Design Ltd | Professional & scientific | 1997 |
| Swiss Services Limited | Transport & logistics | 2002 |
| Switch Commerce (Payments) Limited | Financial services | 2022 |
| Switch IP Limited | Information & communication | 2002 |
| Sycamore Cottage Rest Home Limited | Health & social care | 2014 |
| Syft.Ai Limited | Information & communication | 2025 |
| Sygen International Limited | Professional & scientific | 1996 |
| Sylvia Close Limited | Real estate | 2012 |
| Sylvia Close RTM Company Limited | Households | 2009 |
| Sylvus Limited | Professional & scientific | 2010 |
| Symmetry CF Holdings Ltd | Financial services | 2021 |
| Symmetry Corporate Finance Ltd | Other services | 2019 |
| Symmetry Technologies Ltd | Information & communication | 2026 |
| Syncnovis Consultancy Ltd | Other services | 2025 |
| Synergy Health (UK) Limited | Manufacturing | 1970 |
| Synergy Health Holdings Limited | Financial services | 2007 |
| Synergy Health Investments Limited | Financial services | 1980 |
| Synergy Health Limited | Financial services | 1997 |
| Synergy Health Sterilisation UK Limited | Professional & scientific | 1983 |
| Synergy Health Systems Limited | Information & communication | 2007 |
| Synergy Quest CIC | Health & social care | 2025 |
| Syntra Limited | Professional & scientific | 1998 |
| System Integration Squared Ltd | Information & communication | 2024 |
| Systematic Communications Limited | Information & communication | 2008 |
| Sytrix Limited | Information & communication | 2023 |
| T & B Property Solutions Essex Limited | Real estate | 2016 |
| T & B Property Solutions Kent Limited | Real estate | 2014 |
| T a Estates Ltd | Real estate | 2018 |
| T D Cecil Ltd | Health & social care | 2010 |
| T Lambert Consulting Ltd | Professional & scientific | 2023 |
| T R Project Manage Construct Limited | Construction | 2012 |
| T R Woodworks Ltd | Construction | 2026 |
| T&B Property Solutions Limited | Real estate | 2012 |
| T&D Medical Limited | Health & social care | 2016 |
| T&G Transport Ltd | Education | 2020 |
| T&N Accountancy Ltd | Professional & scientific | 2026 |