| Ross Property Management Ltd | Real estate | 2024 |
| Rosser (Holdings) Limited | Financial services | 2019 |
| Rosser Property Limited | Other services | 2019 |
| Rough Old Glass Limited | Manufacturing | 2010 |
| Roulstone Reed Ltd | Construction | 2018 |
| Roundhill Rehabilitation Limited | Professional & scientific | 2014 |
| Rovian Construction Ltd | Construction | 2025 |
| Rowe Projects Limited | Construction | 2016 |
| Rowe Property Management Ltd | Real estate | 2023 |
| Royle Abbey House Management Company Ltd | Households | 2014 |
| RPB Funerals Ltd | Other services | 2009 |
| Rptc Limited | Extraterritorial | 2012 |
| Rubita Construction Limited | Construction | 2015 |
| Ruda Holiday Park Limited | Hospitality | 2025 |
| Ruff Day Limited | Manufacturing | 2022 |
| Rugged Networks Limited | Manufacturing | 2012 |
| RUH Crew Limited | Arts & recreation | 2018 |
| Rural Accounts Limited | Professional & scientific | 1981 |
| RV Installations Limited | Manufacturing | 2018 |
| RWK Films Ltd | Information & communication | 2020 |
| Ryan Young Properties Ltd | Real estate | 2023 |
| RYD Brand United Kingdom Ltd | Wholesale & retail | 2021 |
| S B S Property Services (North Devon) Limited | Construction | 2010 |
| S B Windsor Limited | Agriculture & fishing | 2007 |
| S Derges Limited | Construction | 2003 |
| S J S Homes (UK) Limited | Real estate | 2002 |
| S J Smith Estate Agents Ltd | Real estate | 2024 |
| S P J T Limited | Real estate | 2018 |
| S P S Carpentry Limited | Construction | 2006 |
| S Robinson Builders & Decorators Limited | Construction | 2017 |
| S Sanders and SON Limited | Real estate | 1957 |
| S&B Services (Yarnscombe) Ltd | Construction | 2008 |
| S.T.M.P Limited | Other services | 2008 |
| Safe Hands Goalkeeper Academy Northdevon Limited | Arts & recreation | 2023 |
| Safe Working Lifts Ltd | Manufacturing | 2016 |
| Safe Working Lifts Refurbishment Ltd | Manufacturing | 2022 |
| Salt and Stone Group Ltd | Manufacturing | 2025 |
| Salt Farming Ltd | Agriculture & fishing | 2025 |
| Salt Media Ltd | Information & communication | 2003 |
| Sam's House Limited | Manufacturing | 2020 |
| Samuels Solicitors LLP | | 2015 |
| Sanamba Limited | Extraterritorial | 2004 |
| Sanctuary Pilates Online Limited | Other services | 2021 |
| Sandbanks Cafe Limited | Hospitality | 2019 |
| Sanderling Close Management Company Limited | Households | 2019 |
| Sanders Motor Company Ltd | Wholesale & retail | 2026 |
| Sanderson Financial Planning Ltd | Financial services | 2011 |
| Sandwell's Painting and Decorating Services Ltd | Construction | 2023 |
| Sanelco Limited | Professional & scientific | 2024 |
| Sapphire GP Limited | Health & social care | 2023 |
| Sarah's PA Solutions Limited | Administrative & support | 2022 |
| Saunton Beach Enterprises Ltd | Wholesale & retail | 2012 |
| Savuti Limited | Professional & scientific | 2012 |
| Schiller Electrical Limited | Construction | 2019 |
| SCL Water Limited | Water & waste | 2007 |
| Scott Delaney Ltd | Administrative & support | 2018 |
| SDB Cooper Utilties Ltd | Construction | 2019 |
| Sea Bee’S Beach School Ltd | Education | 2023 |
| Seahorse Apartments Westward HO! Ltd | Households | 2020 |
| Seailfracombe Limited | Other services | 2009 |
| Seapoduk Ltd | Hospitality | 2025 |
| Seaweed-Uk Ltd | Manufacturing | 2020 |
| Secure Base Developments Ltd | Real estate | 2025 |
| Secure Transform Ltd | Information & communication | 2023 |
| Select Consultancy Services Limited | Professional & scientific | 1993 |
| Selpro Limited | Professional & scientific | 2007 |
| Selprop Ltd | Real estate | 2020 |
| Send the Help CIC | Education | 2025 |
| Serene Dimensions Ltd | Professional & scientific | 2026 |
| SET Construction Group Ltd | Arts & recreation | 2015 |
| Seytol Care Ltd | Health & social care | 2021 |
| SF Ltd | Manufacturing | 2003 |
| SF Power Consulting Limited | Professional & scientific | 2024 |
| SFM Business Limited | Health & social care | 2024 |
| Sgudelli Ltd | Health & social care | 2026 |
| SH Electrical Services Ltd | Construction | 2007 |
| SH1 Commercial Ltd | Real estate | 2025 |
| Shane Jago Ltd | Financial services | 2014 |
| Shareholders Property Limited | Real estate | 2020 |
| Sharing One Language | Education | 1990 |
| Sharron.L Limited | Wholesale & retail | 2012 |
| Shay Coop Ltd | Health & social care | 2025 |
| Sheldon Precision Engineering Limited | Manufacturing | 2014 |
| Sheldon South West Limited | Construction | 2020 |
| Shem Healthcare Limited | Administrative & support | 2016 |
| Shiremoor Ltd | Other services | 2025 |
| Shirwell Park Limited | Information & communication | 2003 |
| Shoreline Business Consulting Ltd | Professional & scientific | 2017 |
| Shush Aesthetics Ltd | Other services | 2022 |
| Sich Grooming Ltd | Wholesale & retail | 2023 |
| Signs of Success Limited | Administrative & support | 2002 |
| Silagesense Ltd | Agriculture & fishing | 2021 |
| Silence Between Sirens CIC | Education | 2026 |
| Silver Bullet Trading Limited | Wholesale & retail | 2011 |
| Silverpond Limited | Administrative & support | 2011 |
| Silverwood Scaffolding Ltd | Construction | 2014 |
| Simple Biogas Systems Ltd | Energy | 2025 |
| Simplifyops. Consulting Ltd | Information & communication | 2026 |
| Siri and Associates Limited | Health & social care | 2015 |
| Sitegains Ltd | Information & communication | 2025 |