| R&M Media Agency Limited | Information & communication | 2015 |
| R. F. Johns Plumbing & Heating Limited | Construction | 2003 |
| R. Malfait Consultants Ltd | Education | 2003 |
| R.C.E.C. Groundworks Limited | Construction | 2015 |
| RAA Events Limited | Hospitality | 2018 |
| Race Mode Ltd | Arts & recreation | 2024 |
| RAD 8 Limited | Wholesale & retail | 2012 |
| Radiography House Enterprises Ltd | Health & social care | 2025 |
| Rafale Properties Ltd | Real estate | 2012 |
| Ragdoll Agency Limited | Wholesale & retail | 2018 |
| Rain OR Shine Roofing Limited | Construction | 2025 |
| Rainbow Care and Companions Ltd | Other services | 2020 |
| Rainbow Supported Living Limited | Health & social care | 2019 |
| Raised Spirit Ltd | Other services | 2017 |
| Rapas Ltd | Health & social care | 2021 |
| Raspa Limited | Health & social care | 2023 |
| Ratherton Power Limited | Energy | 2012 |
| Ratherton Wind Power Limited | Energy | 2013 |
| Rayan Care (Pinhay) Ltd | Health & social care | 2025 |
| Raychantpat Company Limited | Health & social care | 2020 |
| RCF Broadcast Services Ltd | Information & communication | 2023 |
| Rcrf Ltd | Construction | 2007 |
| RCW Trading Limited | Other services | 2024 |
| RD Access Limited | Manufacturing | 2021 |
| React Scaffolding Ltd | Construction | 2022 |
| Read Retail Consulting Limited | Professional & scientific | 2019 |
| Reader Holdings Ltd | Professional & scientific | 2020 |
| Real Consulting Services Ltd | Information & communication | 2003 |
| Reclaim Nation (South West) Limited | Financial services | 2025 |
| Red Elephant Group Ltd | Professional & scientific | 2017 |
| Red Maple Recruitment Limited | Professional & scientific | 2023 |
| Red Tile Construction Limited | Construction | 2017 |
| Redfern & Sons Property Ltd | Construction | 2026 |
| Reed Stone Property Limited | Real estate | 2023 |
| Refurb Depot Limited | Wholesale & retail | 2026 |
| Regency House Union Terrace Limited | Hospitality | 1995 |
| Regenold UK & Ireland Holdings Ltd | Financial services | 2017 |
| Regenold United Kingdom Ltd | Professional & scientific | 2011 |
| Regent House Barnstaple Ltd | Households | 2026 |
| Reid Electrical (South West) Limited | Construction | 2015 |
| Reliant Safecare Ltd | Transport & logistics | 2025 |
| Remedy IT Limited | Information & communication | 2004 |
| Remix Baits Barnstaple Ltd | Manufacturing | 2025 |
| Reno Competitions Ltd | Construction | 2024 |
| Renouf Ltd | Construction | 2019 |
| Renton 2003 Ltd | Hospitality | 2003 |
| RES (Devon) Limited | Construction | 2006 |
| RES (Plumbing & Heating) Limited | Construction | 2016 |
| Resales Limited | Real estate | 2019 |
| Resin IT! Devon Ltd | Construction | 2023 |
| Restless Successors LLP | | 2024 |
| Revive Programmes Limited | Arts & recreation | 2026 |
| RFP Barnstaple Limited | Manufacturing | 2003 |
| RGP Architects Limited | Professional & scientific | 2008 |
| Rhodes Kitchen Limited | Hospitality | 2013 |
| Rich Evans Coaching & Consulting Ltd | Administrative & support | 2022 |
| Richard Davies Computer Services Limited | Other services | 2015 |
| Richard Wright Engineering Services Ltd | Construction | 2012 |
| Ridges Transport Ltd | Wholesale & retail | 2025 |
| Ridley-Holloway Ltd | Real estate | 2014 |
| Rietveld International Ltd | Wholesale & retail | 2019 |
| Right Location Ltd | Real estate | 2010 |
| Rightway Services Ltd | Construction | 2015 |
| Ripple Phone Tech Ltd | Wholesale & retail | 2024 |
| Rise UP Boxing Ltd | Education | 2026 |
| Riversdale Properties (Devon) Limited | Real estate | 2017 |
| Riverside Devon Ltd | Real estate | 2025 |
| Riverside Garage Ltd | Wholesale & retail | 2025 |
| Riverside Residents Barnstaple Limited | Households | 2001 |
| Riversvale Limited | Construction | 2006 |
| RJH Construction (SW) Limited | Construction | 2024 |
| RJW & Partners Limited | Professional & scientific | 2008 |
| RL Cleary Plastering Limited | Construction | 2007 |
| RM Holdings (South West) Ltd | Financial services | 2021 |
| RM Holdings (SW) Ltd | Financial services | 2023 |
| RM Prop Co (SW) Ltd | Construction | 2025 |
| RNC Gifts Ltd | Wholesale & retail | 2020 |
| RO Property Staging and Design Ltd | Professional & scientific | 2026 |
| ROB Fender Ltd | Information & communication | 2021 |
| Robin Bonds Building Contractors Limited | Construction | 2005 |
| Roborough Management Company Limited | Households | 2018 |
| Robson Brown Ltd | Extraterritorial | 1996 |
| Rock Themes International Limited | Construction | 2000 |
| Roddy Assets Limited | Information & communication | 2009 |
| Roddy Management Services Limited | Professional & scientific | 2001 |
| Rolle Quay Inn Barnstaple Ltd | Hospitality | 2025 |
| Rolle Quay Inn Ltd | Hospitality | 2025 |
| Rolle Quay Management Company (Barnstaple) Limited | Households | 2006 |
| Romar Sports Devon Limited | Education | 2021 |
| Romar Sports Limited | Arts & recreation | 2018 |
| RON Sussex and Sons Limited | Construction | 2011 |
| Roofconsult Holdings Limited | Financial services | 2024 |
| Roofconsult Limited | Professional & scientific | 2003 |
| Rooksbridge Yard Ltd | Real estate | 2018 |
| Root Cause Project Community Interest Company | Education | 2022 |
| Roots 2 Roof Supported Living Ltd | Health & social care | 2026 |
| Roots Devon Limited | Hospitality | 2020 |
| Rosewood Properties 2006 Limited | Construction | 2006 |
| Rosie Bracher Ltd | Real estate | 2015 |
| Rosie Bracher Solicitors LLP | | 2018 |